Clinical significance of discordant positive hepatitis c virus transcription-mediated amplification following end of treatment response

Digestive Diseases and Sciences

Volumn 57, Issue 1, 2012, Pages 239-242

  Thadani, Anisha ^a   Harley, Jennifer ^a   Rubin, Jonah ^a   Lebovics, Edward ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Hepatitis C sustained virologic response; Hepatitis C therapy; Hepatitis C virus polymerase chain reaction; Hepatitis C virus transcription mediated amplification

Indexed keywords

ALANINE AMINOTRANSFERASE; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; FOLLOW UP; GENE AMPLIFICATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MEDICAL RECORD REVIEW; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RELAPSE; RETROSPECTIVE STUDY; TRANSCRIPTION MEDIATED AMPLIFICATION BASED ASSAY; TREATMENT RESPONSE; VIREMIA; VIRUS TRANSCRIPTION;

ANTIVIRAL AGENTS; DISEASE PROGRESSION; FOLLOW-UP STUDIES; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; RECURRENCE; RETROSPECTIVE STUDIES; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 84856756412     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1820-x     Document Type: Article

References (10)

1. MG Ghany DB Strader, et al. 2009 Diagnosis, management, and treatment of hepatitis C: an update Hepatology 49 1335 1374 19330875 10.1002/hep.22759 1:CAS:528:DC%2BD1MXkslWjs7o%3D
2. C Sarrazin 2002 Highly sensitive hepatitis C virus RNA detection methods: molecular backgrounds and clinical significance J Clin Virol 25 S23 S29 12467774 10.1016/S1386-6532(02)00195-6 1:CAS:528:DC%2BD38XptFeqsb8%3D
3. L Comanor F Anderson, et al. 2001 Transcription-mediated amplification is more sensitive than conventional PCR-based assays for detecting residual serum HCV RNA at end of treatment Am J Gastroenterol 96 2968 2972 11693334 10.1111/j.1572-0241.2001.04669.x 1:CAS:528:DC%2BD3MXot1Cgsrs%3D (Pubitemid 32959541)
4. JS Kadam SA Gonzalez, et al. 2007 Prognostic significance of hepatitis C virus RNA detection by transcription-mediated ampflication with negative polymerase chain reaction during therapy with peginterferon α and ribavirin Dig Dis Sci 52 2525 2530 17406826 10.1007/s10620-006-9735-7 1:CAS:528:DC%2BD2sXhtVSisLvP (Pubitemid 47373914)
5. C Sarrazin G Teuber, et al. 2000 Detection of residual hepatitis C virus RNA by transcription-mediated amplification in patients with complete virologic response according to polymerase chain reaction-based assays Hepatology 32 818 823 11003628 10.1053/jhep.2000.17709 1:CAS:528:DC%2BD3cXnslemsbk%3D
6. C Sarrazin DA Hendricks, et al. 2001 Assessment, by transcription- mediated amplification, of virologic response in patients with chronic hepatitis C virus treated with peginterferon alpha-2a J Clin Microbiol 39 2850 2955 11474002 10.1128/JCM.39.8.2850-2855.2001 1:CAS:528:DC%2BD3MXmsVOmsr8%3D (Pubitemid 32744000)
7. M Gerotto F Dal Pero, et al. 2006 Hepatitis C minimal residual viremia (MVR) detected by TMA at the end of Peg-IFN plus ribavirin therapy predicts post-treatment relapse J Hepatology 44 83 87 10.1016/j.jhep.2005.08.016 1:CAS:528:DC%2BD2MXht12ktLjJ (Pubitemid 41772520)
8. C Morishima TR Morgan, et al. 2006 HCV RNA detection by TMA during hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial Hepatology 44 360 367 16871570 10.1002/hep.21265 1:CAS:528:DC%2BD28XptVKmt7Y%3D (Pubitemid 44214875)
9. C Morishima TR Morgan, et al. 2008 Interpretation of positive TMA test results from PCR-negative samples obtained after treatment of chronic hepatitis C Hepatology 48 1412 1419 18816437 10.1002/hep.22487 1:CAS:528: DC%2BD1cXhsVKmtrbL
10. N Veerapu S Raghuraman, et al. 2011 Sporadic reappearance of minute amounts of hepatitis C virus RNA after successful therapy stimulates cellular immune responses Gastroenterology 140 676 685 21040725 10.1053/j.gastro.2010.10. 048 1:CAS:528:DC%2BC3MXhtlSksb4%3D