Competition between anion binding and dimerization modulates Staphylococcus aureus phosphatidylinositol-specific phospholipase C enzymatic activity

Journal of Biological Chemistry

Volumn 287, Issue 48, 2012, Pages 40317-40327

  Cheng, Jiongjia ^a   Goldstein, Rebecca ^a   Stec, Boguslaw ^b   Gershenson, Anne ^c   Roberts, Mary F ^a  

^a BOSTON COLLEGE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION BINDING; ANIONIC LIPIDS; ENZYMATIC ACTIVITIES; ENZYME CONCENTRATIONS; KEY RESIDUES; KINETIC EVIDENCE; MEMBRANE BINDING; MONOMERIC PROTEINS; OPTIMAL ENZYME ACTIVITY; PATHOGENIC BACTERIUM; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; S. AUREUS; SEQUENCE SIMILARITY; SPECIFIC ACTIVITY; SPECIFIC BINDING; STAPHYLOCOCCUS AUREUS; STRUCTURAL FEATURE; VIRULENCE FACTORS;

BACTERIA; DIMERIZATION; DIMERS; DYES; NEGATIVE IONS; PHOSPHOLIPIDS; PROTEINS;

ENZYME ACTIVITY;

PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C;

ANION TRANSPORT; ARTICLE; BACTERIAL VIRULENCE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROPHOBICITY; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS;

ANIONS; BACTERIAL PROTEINS; BINDING SITES; DIMERIZATION; KINETICS; PHOSPHOINOSITIDE PHOSPHOLIPASE C; PROTEIN BINDING; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 84870038612     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.395277     Document Type: Article

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