Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 10130-10135

  Schimer, Jiří ^a,b   Cígler, Petr ^a   Veselý, Jan ^b   Grantz Šašková, Klára ^a   Lepšík, Martin ^a   Brynda, Jiří ^a,c   Řezáčová, Pavlína ^a,c   Kožíšek, Milan ^a   Císařová, Ivana ^b   Oberwinkler, Heike ^d   Kraeusslich, Hans Georg ^d   Konvalinka, Jan ^a,b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR;

ARTICLE; COVALENT BOND; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR LIBRARY; MOLECULAR MODEL; MOLECULAR WEIGHT; NONHUMAN; X RAY ANALYSIS;

BENZODIAZEPINES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV INFECTIONS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870027189     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301249q     Document Type: Article

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