Effects of a low-dose oral estrogen only treatment on bone mineral density and quantitative ultrasonometry in postmenopausal women

Gynecological Endocrinology

Volumn 28, Issue 12, 2012, Pages 1002-1005

  Ziller, May ^a   Herwig, Julia ^a   Ziller, Volker ^a   Kauka, Annette ^a   Kostev, Karel ^b   Hadji, Peyman ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b IQVIA   (United States)

Author keywords

Bone mineral density; Conjugated estrogen; Dual energy x ray absortiometry; Quantitative ultrasonometry

Indexed keywords

CONJUGATED ESTROGEN;

ADULT; AGED; ARTICLE; BONE DENSITY; CALCANEUS; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ECHOGRAPHY; ESTROGEN THERAPY; FEMALE; HUMAN; HYSTERECTOMY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; OPEN STUDY; PHALANX; POSTMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ULTRASONOMETRY;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; COHORT STUDIES; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); FEMALE; GERMANY; HUMANS; HYSTERECTOMY; MATCHED-PAIR ANALYSIS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE; PROSPECTIVE STUDIES; RISK FACTORS; ULTRASONOGRAPHY;

EID: 84870019647     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2012.705369     Document Type: Article

References (26)

1. DVO. DVO Guideline 2009 for Prevention, Diagnosis and Terapy of Osteoporosis in Adults. Hef 11 A.D.;1(1-104):55-74.
2. Pfeilschifer J, Pientka L, Scheidt-Nave Ch. [Osteoporosis in Germany, 2003-a stock taking]. MMW Fortschr Med 2003;145:42-43.
3. Cauley JA, Seeley DG, Ensrud K, Ettinger B, Black D, Cummings SR. Estrogen replacement therapy and fractures in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 1995;122:9-16.
4. Torgerson DJ, Bell-Syer SE. Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials. JAMA 2001;285:2891-2897.
5. Richman S, Edusa V, Fadiel A, Nafolin F. Low-dose estrogen therapy for prevention of osteoporosis: working our way back to monotherapy. Menopause 2006;13:148-155.
6. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, et al. Efects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004;291:1701-1712.
7. Cauley JA, Robbins J, Chen Z, Cummings SR, Jackson RD, LaCroix AZ, LeBof M, et al. Efects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA 2003;290:1729-1738.
8. Jackson RD, Wactawski-Wende J, LaCroix AZ, Pettinger M, Yood RA, Watts NB, Robbins JA, et al. Efects of conjugated equine estrogen on risk of fractures and BMD in postmenopausal women with hysterectomy: results from the women's health initiative randomized trial. J Bone Miner Res 2006;21:817-828.
9. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, et al. Risks and benefts of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-333.
10. Al-Azzawi F. Prevention of postmenopausal osteoporosis and associated fractures: Clinical evaluation of the choice between estrogen and bisphosphonates. Gynecol Endocrinol 2008;24:601-609.
11. Khosla S, Melton LJ 3rd, Riggs BL. Te unitary model for estrogen defciency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res 2011;26:441-451.
12. Menostar: a low-dose estrogen patch for osteoporosis. Obstet Gynecol 2005;105:432-433.
13. Gambacciani M, Cappagli B, Ciaponi M, Pepe A, Vacca F, Genazzani AR. Ultra low-dose hormone replacement therapy and bone protection in postmenopausal women. Maturitas 2008;59:2-6.
14. Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH. Bone response to treatment with lower doses of conjugated estrogens with and without medroxyprogesterone acetate in early postmenopausal women. Osteoporos Int 2005;16:372-379.
15. Hadji P. [Possibilities and limitations of quantitative ultrasonometry in clinical practise]. Dtsch Med Wochenschr 2003;128:951-953.
16. Hadji P. [Possibilities and limitations of quantitative ultrasonometry in clinical practise]. Dtsch Med Wochenschr 2003;128:951-953.
17. Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH. Bone response to treatment with lower doses of conjugated estrogens with and without medroxyprogesterone acetate in early postmenopausal women. Osteoporos Int 2005;16:372-379.
18. Rozenberg S, Neusy S, Barudy J, Fellemens C, Jahjah L. [Estrogen replacement therapy: for whom, why and how?]. Rev Med Brux 2002;23:A382-A389.
19. Genant HK, Lucas J, Weiss S, Akin M, Emkey R, McNaney-Flint H, Downs R, et al. Low-dose esterifed estrogen therapy: efects on bone, plasma estradiol concentrations, endometrium, and lipid levels. Estratab/Osteoporosis Study Group. Arch Intern Med 1997;157:2609-2615.
20. Gambacciani M, Cappagli B, Ciaponi M, Pepe A, Vacca F, Genazzani AR. Ultra low-dose hormone replacement therapy and bone protection in postmenopausal women. Maturitas 2008;59:2-6.
21. Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH. Bone response to treatment with lower doses of conjugated estrogens with and without medroxyprogesterone acetate in early postmenopausal women. Osteoporos Int 2005;16:372-379.
22. Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH. Efect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women. JAMA 2002;287:2668-2676.
23. Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH. Bone response to treatment with lower doses of conjugated estrogens with and without medroxyprogesterone acetate in early postmenopausal women. Osteoporos Int 2005;16:372-379.
24. Management of osteoporosis in postmenopausal women:2010 position statement of Te North American Menopause Society. Menopause 2010;17:25-54.
25. Gambacciani M, de Aloysio D, Elia D, van der Mooren MJ, Hadji P, Wüster C. Quantitative ultrasound (QUS) of bone in the management of postmenopausal women. Maturitas 2004;47:139-149.
26. Heikkinen J. Hormone therapy: maximizing the benefts. Gynecol Endocrinol 2006;22:160-162.