Diazoxide may protect endothelial glycocalyx integrity during coronary artery bypass grafting

Scandinavian Cardiovascular Journal

Volumn 46, Issue 6, 2012, Pages 339-344

  Mennander, Ari Adolf ^a   Shalaby, Ahmed ^a   Oksala, Niku ^a   Leppänen, Tiina ^b   Hämäläinen, Mari ^b   Huovinen, Sanna ^a   Zhao, Fang ^c   Moilanen, Eeva ^c   Tarkka, Matti ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Coronary artery bypass grafting; Glycocalyx; Ischemia reperfusion injury

Indexed keywords

DIAZOXIDE; HYALURONIC ACID; SYNDECAN 1;

ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; GLYCOCALYX; HEART EDEMA; HEART MUSCLE BIOPSY; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; ULTRASTRUCTURE;

BIOLOGICAL MARKERS; BIOPSY; CORONARY ARTERY BYPASS; CORONARY ARTERY DISEASE; DIAZOXIDE; DOUBLE-BLIND METHOD; ENDOTHELIAL CELLS; FINLAND; GLYCOCALYX; HUMANS; HYALURONIC ACID; MICROSCOPY, ELECTRON; PILOT PROJECTS; PROSPECTIVE STUDIES; SYNDECAN-1; TIME FACTORS; TREATMENT OUTCOME;

EID: 84870005016     PISSN: 14017431     EISSN: 16512006     Source Type: Journal    
DOI: 10.3109/14017431.2012.717303     Document Type: Article

References (20)

1. Al-Dadah AS, Voeller R, Shuessler RB, Damiano R, Lawton JS. Maintenance of myocyte volume homeostasis during stress by Diazoxide is cardioprotective. Ann Thorac Surg. 2007; 84: 857-62.
2. Mizutani S, Al-Dadah AS, Bloch J B, Prasad S M, Diodato MD, Shuessler RB, et al. Hyperkalemic cardioplegiainduced myocyte swelling and contractile dysfunction: Prevention by Diazoxide. Ann Thorac Surg. 2006; 81: 154-9.
3. Broadhead M W, Kharbanda R K, Peters M J, MacAllister R J. K ATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo. Circulation. 2004; 110: 2077-82.
4. Van den Berg B M, Vink H, Spaan J AE. The endothelial glycocalyx protects against myocardial edema. Circulation Res. 2003; 4: 592-4.
5. Rehm M, Bruegger D, Christ F, Conzen P, Thiel M, Jacob M, et al. Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation. 2007; 116: 1896-906.
6. Svennevig K, Hoel TN, Thiara AS, Kolset S O, Castelheim A, Mollnes TE, et al. Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass. Perfusion. 2008; 23: 165-71.
7. Shalaby A, Mennander A, Rinne T, Oksala N, Aanismaa R, Narkilahti S, et al. Aquaporin-7 expression during coronary artery bypass grafting with Diazoxide. Scand Cardiovasc J. 2001; 45: 354-9.
8. McCully J D, Wakiyama H, Cowan D B, Federman M, Parker RA, Levitsky S. Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery. Ann Thorac Surg. 2002; 74: 2138-46.
9. Beresewicz A, Maczewski M, Duda M. Effect of classic preconditioning and Diazoxide on endothelial function and O 2 and NO generation in the post-ischemic guinea-pig heart. Cardiovasc Res. 2004; 63: 118-29.
10. Deja MA, Malinowski M, Golba K, Kajor M, Lebda-Wyborny T, Hudziak D, et al. Diazoxide protects myocardial mitochondria, metabolism, and function during cardiac surgery: A double-blind randomized feasibility study of diazoxide-supplemented cardioplegia. J Thorac Cardiovasc Surg. 2009; 137: 997-1004.
11. Chappell D, Jacob M, Hofmann-Kiefer K, Bruegger D, Rehm M, Conzen P, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007; 107: 776-84.
12. Annecke T, Chappell D, Chen C, Jacob M, Welsch U, Sommerhoff CP, et al. Sevoflurane preserves the endothelial glycocalyx against ischaemia-reperfusion injury. Br J Anaesth. 2010; 104: 414-21.
13. Chappell D, Jacob M, Hofmann-Kiefer K, Rehm M, Welsch U, Conzen P, et al. Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion. Cardiovasc Res. 2009; 83: 388-96.
14. Jacob M, Paul O, Mahringer L, Chappell D, Rehm M, Welsch U, et al. Albumin augmentation improves condition of guinea pig hearts after 4 hr of cold ischemia. Transplantation. 2009; 87: 956-65.
15. Brands J, Spaan J AE, Van den Berg B M, Vink H, Van Teeffelen JWGE. Acute attenuation of glycocalyx barrier properties increases coronary blood volume independently of coronary flow reserve. Am J Physiol Heart Circ Physiol. 2010; 298: H515-23.
16. Nelson A, Berkestedt I, Schmidtchen A, Ljunggren L, Bodelsson M. Increased levels of Glycosaminoglycans during septic shock: Relation to mortality and the antibacterial actions of plasma. Shock. 2008; 30: 623-7.
17. Johansson P I, Sorensen AM, Perner A, Welling K L, Wanscher M, Larsen CF, et al. High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J Thromb Haemost. 2012; 10: 207-16.
18. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission Syndecan-1 level, amarker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg. 2011; 254: 194-200.
19. Johansson P, Sorensen A M, Perner A, Welling KL, Wanscher M, Larsen CF, et al. Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Critical Care. 2011; 15: 272-82.
20. Bruegger D, Rehm M, Abicht J, Paul JO, Stoeckelhuber M, Pfirrmann M, et al. Shedding of the endothelial glycocalyx during cardiac surgery: On-pump versus off-pump coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2009; 138: 1445-7.