Insulin receptor and glucose transporters mRNA expression throughout the menstrual cycle in human endometrium: Aphysiological and cyclical condition of tissue insulin resistance

Gynecological Endocrinology

Volumn 28, Issue 12, 2012, Pages 1014-1018

  Mioni, Roberto ^a   Mozzanega, Bruno ^b   Granzotto, Marnie ^a   Pierobon, Alice ^a   Zuliani, Laura ^a   Maffei, Pietro ^a   Blandamura, Stella ^a   Grassi, Sara ^b   Sicolo, Nicola ^a   Vettor, Roberto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Department of Gynaecological and Human Reproduction Sciences ^*  (Italy)

Author keywords

Endometrial insulin resistance; Glut1; Glut4; Healthy women; IGFs; Insulin receptor

Indexed keywords

GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; INSULIN GROWTH FACTOR I; INSULIN GROWTH FACTOR II; INSULIN RECEPTOR; MESSENGER RNA; SOMATOMEDIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; ENDOMETRIUM; EPITHELIUM CELL; FEMALE; FOLLICULAR PHASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; LUTEAL PHASE; MENSTRUAL CYCLE; MENSTRUATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STROMA CELL;

ADULT; ANTIGENS, CD; ENDOMETRIUM; EPITHELIAL CELLS; FEMALE; FOLLICULAR PHASE; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 4; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; LUTEAL PHASE; MENSTRUAL CYCLE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STROMAL CELLS;

EID: 84870002875     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2012.705367     Document Type: Article

References (26)

1. Ferenczy A, Bergeron C. Histology of the human endometrium: from birth to senescence. Ann N Y Acad Sci 1991;622:6-27.
2. Krikun G, Lockwood CJ. Steroid hormones, endometrial gene regulation and the Sp1 family of proteins. J Soc Gynecol Investig 2002;9:329-334.
3. Adesanya OO, Zhou J, Bondy CA. Cellular localization and sex steroid regulation of insulin-like growth factor binding protein messenger ribonucleic acids in the primate myometrium. J Clin Endocrinol Metab 1996;81:2495-2501.
4. von Wolf M, Ursel S, Hahn U, Steldinger R, Strowitzki T. Glucose transporter proteins (GLUT) in human endometrium: expression, regulation, and function throughout the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab 2003;88:3885-3892.
5. Mioni R, Chiarelli S, Xamin N, Zuliani L, Granzotto M, Mozzanega B, Mafei P, et al. Evidence for the presence of glucose transporter 4 in the endometrium and its regulation in polycystic ovary syndrome patients. J Clin Endocrinol Metab 2004;89:4089-4096.
6. Mozzanega B, Mioni R, Granzotto M, Chiarelli S, Xamin N, Zuliani L, Sicolo N, et al. Obesity reduces the expression of GLUT4 in the endometrium of normoinsulinemic women afected by the polycystic ovary syndrome. Ann N Y Acad Sci 2004;1034:364-374.
7. Fornes R, Ormazabal P, Rosas C, Gabler F, Vantman D, Romero C, Vega M. Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia. Mol Med 2010;16:129-136.
8. Sheets EE, Tsibris JC, Cook NI, Virgin SD, DeMay RM, Spellacy WN. In vitro binding of insulin and epidermal growth factor to human endometrium and endocervix. Am J Obstet Gynecol 1985;153:60-65.
9. Strowitzki T, von Eye HC, Kellerer M, Häring HU. Tyrosine kinase activity of insulin-like growth factor I and insulin receptors in human endometrium during the menstrual cycle: cyclic variation of insulin receptor expression. Fertil Steril 1993;59:315-322.
10. Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, Le Shay N, et al. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology 2006;147:1097-1121.
11. Kelly RW, King AE, Critchley HO. Cytokine control in human endometrium. Reproduction 2001;121:3-19.
12. Krikun G, Schatz F, Taylor R, Critchley HO, Rogers PA, Huang J, Lockwood CJ. Endometrial endothelial cell steroid receptor expression and steroid efects on gene expression. J Clin Endocrinol Metab 2005;90:1812-1818.
13. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470.
14. Foresta C, Mioni R, Bordon P, Miotto D, Montini G, Varotto A. Erythropoietin stimulates testosterone production in man. J Clin Endocrinol Metab 1994;78:753-756.
15. Serafni P, Da Rocha AM, De Toledo Osório CA, Smith GD, Hassun PA, da Silva IG, Da Motta EL, Baracat EC. Protein profle of the luteal phase endometrium by tissue microarray assessment. Gynecol Endocrinol 2009;25:587-592.
16. Molloy CA, May FE, Westley BR. Insulin receptor substrate-1 expression is regulated by estrogen in the MCF-7 human breast cancer cell line. J Biol Chem 2000;275:12565-12571.
17. González C, Alonso A, Grueso NA, Esteban MM, Fernández S, Patterson AM. Efect of treatment with diferent doses of 17-beta-estradiol on the insulin receptor. Life Sci 2002;70:1621-1630.
18. Villa P, Sagnella F, Perri C, Suriano R, Costantini B, Macrí F, Ricciardi L, Lanzone A. Low-and standard-estrogen dosage in oral therapy: dose-dependent efects on insulin and lipid metabolism in healthy postmenopausal women. Climacteric 2008;11:498-508.
19. Zhou J, Dsupin BA, Giudice LC, Bondy CA. Insulin-like growth factor system gene expression in human endometrium during the menstrual cycle. J Clin Endocrinol Metab 1994;79:1723-1734.
20. Nayak NR, Giudice LC. Comparative biology of the IGF system in endometrium, decidua, and placenta, and clinical implications for foetal growth and implantation disorders. Placenta 2003;24:281-296.
21. Corleta H, Capp E, Strowitzki T. Cycle modulation of insulin-like growth factor-binding protein 1 in human endometrium. Braz J Med Biol Res 2000;33:1387-1391.
22. Irwin JC, de las Fuentes L, Dsupin BA, Giudice LC. Insulin-like growth factor regulation of human endometrial stromal cell function: coordinate efects on insulin-like growth factor binding protein-1, cell proliferation and prolactin secretion. Regul Pept 1993;48:165-177.
23. Rutanen EM. Insulin-like growth factors and insulin-like growth factor binding proteins in the endometrium. Efect of intrauterine levonorgestrel delivery. Hum Reprod 2000;15 Suppl 3:173-181.
24. Mueckler M. Insulin resistance and the disruption of Glut4 trafcking in skeletal muscle. J Clin Invest 2001;107:1211-1213.
25. Cooper BC, Sites CK, Casson PR, Toth MJ. Ovarian suppression with a gonadotropin-releasing hormone agonist does not alter insulin-stimulated glucose disposal. Fertil Steril 2007;87:1131-1138.
26. Dumesic DA, Nielsen MF, Abbott DH, Eisner JR, Nair KS, Rizza RA. Insulin action during variable hyperglycemic-hyperinsulinemic infusions in hyperandrogenic anovulatory patients and healthy women. Fertil Steril 1999;72:458-466.