Possibility of undifferentiated human thigh adipose stem cells differentiating into functional hepatocytes

Archives of Plastic Surgery

Volumn 39, Issue 6, 2012, Pages 593-599

  Lee, Jong Hoon ^a,b   Lee, Kuk Han ^a   Kim, Min Ho ^b,c   Kim, Jun Pyo ^d   Lee, Seung Jae ^d   Yoon, Jinah ^e  

^a Eulji General Hospital   (South Korea)

^b Eulji University   (South Korea)

^c Korea University   (South Korea)

^d CL Aesthetic Clinic   (South Korea)

^e Seoul Women University   (South Korea)

Author keywords

Adipose tissue; Cell differentiation; Hepatocytes; Stem cells; Thigh

Indexed keywords

ALBUMIN; ALBUMIN ANTIBODY; CYTOKINE; GROWTH FACTOR; HORMONE; MESSENGER RNA;

ADIPOSE DERIVED STEM CELL; ADIPOSE TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LIVER CELL; PERIODIC ACID SCHIFF STAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THIGH;

EID: 84869989132     PISSN: 22346163     EISSN: 22346171     Source Type: Journal    
DOI: 10.5999/aps.2012.39.6.593     Document Type: Article

References (19)

1. Banas A, Teratani T, Yamamoto Y, et al. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology 2007;46:219-228.
2. Talens-Visconti R, Bonora A, Jover R, et al. Human mesen-chymal stem cells from adipose tissue: differentiation into hepatic lineage. Toxicol In Vitro 2007;21:324-329.
3. Planat-Benard V, Silvestre JS, Cousin B, et al. Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation 2004;109: 656-663.
4. Seo MJ, Suh SY, Bae YC, et al. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun 2005;328:258-264.
5. Oh SH, Miyazaki M, Kouchi H, et al. Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun 2000;279:500-504.
6. Minguell JJ, Erices A, Conget P. Mesenchymal stem cells. Exp Biol Med (Maywood) 2001;226:507-520.
7. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
8. Lee RH, Kim B, Choi I, et al. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 2004;14: 311-324.
9. Sakaguchi Y, Sekiya I, Yagishita K, et al. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005;52:2521-2529.
10. Dresser R. Ethical issues in embryonic stem cell research. JAMA 2001;285:1439-1440.
11. Nakahara H, Goldberg VM, Caplan AI. Culture-expanded human periosteal-derived cells exhibit osteochondral potential in vivo. J Orthop Res 1991;9:465-476.
12. Asakura A, Komaki M, Rudnicki M. Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation. Differentiation 2001;68: 245-253.
13. Kinoshita T, Miyajima A. Cytokine regulation of liver development. Biochim Biophys Acta 2002;1592:303-312.
14. Michalopoulos GK, Bowen WC, Mule K, et al. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expr 2003;11:55-75.
15. McLean AB, D'Amour KA, Jones KL, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 2007;25:29-38.
16. Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002;109:1291-1302.
17. Lazaro CA, Croager EJ, Mitchell C, et al. Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes. Hepatology 2003;38:1095-1106.
18. Sakai Y, Jiang J, Kojima N, et al. Enhanced in vitro maturation of fetal mouse liver cells with oncostatin M, nicotin-amide, and dimethyl sulfoxide. Cell Transplant 2002;11: 435-441.
19. Schmelzer E, Wauthier E, Reid LM. Te phenotypes of plu-ripotent human hepatic progenitors. Stem Cells 2006;24: 1852-1858.