A priori assessment of ecotoxicological risks linked to building a hospital

Chemosphere

Volumn 90, Issue 3, 2013, Pages 1037-1046

  Perrodin, Yves ^a   Christine, Bazin ^c   Sylvie, Bony ^a,b   Alain, Devaux ^a,b   Jean Luc, Bertrand Krajewski ^d   Cécile, Cren Olivé ^e   Audrey, Roch ^f   Elodie, Brelot ^g  

^a UNIVERSITÉ DE LYON   (France)

^b CEMAGREF   (France)

^c INSAVALOR   (France)

^d UNIVERSITÉ DE LYON   (France)

^e UNIVERSITÉ DE LYON   (France)

^f Syndicat Intercommunal de Bellecombe   (France)

^g GRAIE   (France)

Author keywords

Chemical pollutants; Ecological risk assessment; Ecotoxicological risk assessment; Hospitals wastewater; Pharmaceuticals; WWTP

Indexed keywords

AQUATIC ECOSYSTEMS; AQUATIC ORGANISMS; CELL CULTURE; DRUG PRODUCTS; EFFLUENTS; HOSPITALS; SALMONELLA; SOAPS (DETERGENTS); SURFACE WATERS; WASTE TREATMENT; WASTEWATER TREATMENT; WATER POLLUTION; WATER TREATMENT;

AMES FLUCTUATION ASSAYS; CHEMICAL POLLUTANTS; ECOLOGICAL RISK ASSESSMENT; ECOTOXICOLOGICAL RISK ASSESSMENT; ECOTOXICOLOGICAL RISKS; PSEUDOKIRCHNERIELLA SUBCAPITATA; SALMONELLA TYPHIMURIUM; WWTP;

RISK ASSESSMENT;

AQUATIC ENVIRONMENT; BACTERIUM; BIOASSAY; CHEMICAL POLLUTANT; DISCHARGE; ECOTOXICOLOGY; ENVIRONMENTAL RISK; GENOTOXICITY; HOSPITAL SECTOR; INVERTEBRATE; MICROALGA; OSTRACOD; PROJECT ASSESSMENT; RISK ASSESSMENT; TOXICITY TEST; WASTE FACILITY; WASTE TREATMENT; WASTEWATER;

AMES TEST; ARTICLE; BIOASSAY; BRACHIONUS CALYCIFLORUS; COMET ASSAY; ECOTOXICOLOGY; FRANCE; HETEROCYPRIS INCONGRUENS; HOSPITAL BUILDING; HOSPITAL WASTE; NONHUMAN; OSTRACOD; PHYSICAL CHEMISTRY; PLANKTON; PSEUDOKIRCHNERIELLA SUBCAPITATA; RISK ASSESSMENT; RIVER; ROTIFERA; SEWER; URBAN AREA; WASTE DISPOSAL; WASTE WATER TREATMENT PLANT; WATERSHED;

ALPS; FRANCE;

BRACHIONUS CALYCIFLORUS; HETEROCYPRIS INCONGRUENS; SALMONELLA TYPHIMURIUM; SALMONIDAE; SELENASTRUM CAPRICORNUTUM;

EID: 84869881517     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2012.08.049     Document Type: Article

References (83)

1. Adam C., Debayle C., Carel D., Cavalié I. Les produits radiopharmaceutiques dans les effluents hospitaliers et domestiques. Envir. Risques Sante 2006, 5:254-260.
2. ADEME, 2002. évaluation de l'écocompatibilité des scénarios de stockage et de valorisation des déchets. Agence De l'Environnement et de la Maîtrise de l'énergie, Angers, France. p. 12.
3. Anderson S.L., Wild G.C. Linking genotoxic responses and reproductive success in ecotoxicology. Environ. Health Perspect. 1994, 102:9-12.
4. Andrén C., Eklund B., Gravenfors E., Kukulska Z., Tarkpea M. A multivariate biological and chemical characterization of industrial effluents connected to municipal sewage treatment plants. Environ. Toxicol. Chem. 1998, 17:228-233.
5. Ankley G.T., Schubauer-Berigan M.K., Monson P.D. Influence of pH and hardness on toxicity of ammonia to the amphipod Hyalella azteca. Can. J. Fish. Aquat. Sci. 1995, 52:2078-2083.
6. ATSDR, 2004. Toxicological profiles for Ammonia. Agency for Toxic Substances and Disease Registry, Atlanta, GA, US Department of Health and Human Services, Public Health Services. .
7. Babut M., Perrodin Y., Bray M., Clément B., Delolme C., Devaux A., Durrieu C., Garric J., Vollat B., Becart D., Charrier C. évaluation des risques écologiques causés par des matériaux de dragage: proposition d'une approche adaptée aux dépôts en gravière en eau. Revue des Sciences de l'Eau 2002, 15:615-639.
8. Boillot, C., Angerville, R., Panouillères, M., Perrodin, Y., 2007. Ecotoxicological risk assessment of hospital wastewater discharge: characterization of combined effect due to binary mixtures of three surfactants and three disinfectants towards Daphnia magna (Poster). 17th SETAC, Europe, Porto (Portugal).
9. Boillot C., Bazin C., Tissot-Guerraz F., Droguet J., Perraud M., Cetre J.C., Trepo D., Perrodin Y. Daily physicochemical, microbiological and ecotoxicological fluctuations of a hospital effluent according to technical and care activities. Sci. Total Environ. 2008, 403:113-129.
10. Brown K.D., Kulis J., Thomson B., Chapman T.H., Mawhinney D.B. Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Sci. Total Environ. 2006, 366:772-783.
11. Carey, J., Cook, P., Giesy, J., Hodson, P., Murir, D., Owens, W., Solomon, K., 1998. Ecotoxicological risk assessment of the chlorinated organic chemical. SETAC Pellston Workshop on Environmental Risk Assessment for Organochlorine Compounds. Soc. Environ. Toxicol. Chem. (SETAC), Aliston, Ontario, Canada, p. 397.
12. CEAEQ Procédure d'évaluation des risques écotoxicologiques pour la réhabilitation des terrains contaminés 1998, Centre d'Expertise en Analyse Environnementale du Québec, Québec, p. 139.
13. Chang X.T., Meyer M., Liu X., Zhao Q., Chen H., Chen J.-A., Qiu Z., Yang L., Cao J., Shu W. Determination of antibiotics in sewage from hospitals, nursery and slaughter house, wastewater treatment plant and source water in Chongqing region of Three Gorge Reservoir in China. Environ. Pollut. 2010, 158:1444-1450.
14. Charissou A.M., Jourdain M.J., Pandard P., Poulsen V., Devillers J., Férard J.F., Bispo A. Selection of a battery of bioassay for the assessment of complex media: a review. Tech. Sci. Meth. 2006, 5:101-110.
15. Clément B., Cadier C. Development of a new laboratory freshwater/sediment microcosm test. Ecotoxicology 1998, 7:279-290.
16. Clément B., Persoone G., Colin J., Du-Delepierre A. Estimation of the hazard of landfills through toxicity testing of leachates. I. Determination of leachate toxicity with a battery of acute tests. Chemosphere 1996, 33:2303-2320.
17. Davoren M., Fogarty A.M. A test battery for the ecotoxicological evaluation of the agri-chemical. Environ. Ecotoxicol. Environ. Safe. 2004, 59:116-122.
18. Davoren M., Ni Shúilleabháin S., O'Halloran J., Hartl M.G.J., Sheehan D., O'Brien N.M., Van Pelt F.N.A.M., Mothersill C. A test battery approach for the ecotoxicological evaluation of estuarine sediments. Ecotoxicology 2005, 14:741-755.
19. Dayeh, V.R., Bols, N.C., Shchirmer, C., 2003. The use of fish-derived cell lines for investigation of environmental contaminants. Curr. Protoc. Toxicol., 151-157.
20. Depledge M.H. Genetic ecotoxicology: an overview. J. Exp. Mar. Biol. Ecol. 1996, 200:57-66.
21. Devaux A., Flammarion P., Bernardon V., Garric J., Monod G. Monitoring of the chemical pollution of the river Rhône through measurement of DNA damage and cytochrome P4501A induction in chub (Leuciscus cephalus). Mar. Environ. Res. 1998, 46:257-262.
22. ECB, 2003. Technical Guidance Document (TGD) in support of Commission Directive 93/67/EEC on Risk Assessment for new notified substances, Commission Regulation (EC) No. 1488/94 on Risk Assessment for existing substances and Directive 98/8/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market. European Chemical Bureau, Ispra, Italy, p. 1044.
23. Emmanuel E., Hanna K., Bazin C., Keck G., Clement B., Perrodin Y. Fate of glutaraldehyde in hospital wastewater and combined effects of glutaraldehyde and surfactants on aquatic organisms. Environ. Int. 2005, 31:399-406.
24. Emmanuel E., Keck G., Blanchard J.M., Vermande P., Perrodin Y. Toxicological effects of disinfections using sodium hypochlorite on aquatic organisms and its contribution to AOX formation in hospital wastewater. Environ. Int. 2004, 30:891-900.
25. Environment Agency of United Kingdom Ecological Risk Assessment, a public consultation on a frame work and methods for assessing harm to ecosystems from contaminants soil 2003, Environment Agency of United Kingdoms, Bristol, UK, p. 104.
26. Environnement Canada, Santé Canada Eaux usées chlorées - Rapport d'évaluation - évaluation des substances de la première Liste des substances d'intérêt prioritaire (LSIP1) 1993, Gouvernement du Canada, Canada, p. 34.
27. Escher B.I., Baumgartner R., Koller M., Treyer K., Judit L., McArdell C.S. Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater. Water Res. 2011, 45:75-92.
28. Ferrari, B., Garric, J., Paxeus, N., Pollio, A., 2003. Ecotoxicity of 6 pharmaceuticals found in effluent of sewage treatment plants and surface water in Europe: overview and interest for the current European draft guideline. In: Cemagref (Ed.), Envipharma, Lyon.
29. Ferrari B., Mons R., Vollat B., Fraysse B., Paxeus N., Lo Giudice R., Pollio A., Garric J. Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?. Environ. Toxicol. Chem. 2004, 23:1344-1354.
30. Gartiser S., Willmund R., Brinker L., Erbe T., Kümmerer K. Contamination of hospital wastewater with hazardous compounds as defined by § 7a WHG. Acta Hydroch. Hydrobiol. 1996, 24:90-97.
31. Gautam A.K., Kumar S., Sabumon P.C. Preliminary study of physico-chemical treatment options for hospital wastewater. J. Environ. Manage. 2007, 83:298-306.
32. Gibert J., Culver D.C. Assessing and conserving groundwater biodiversity: an introduction. Freshw. Biol. 2009, 54:639-648.
33. Gibert J., Culver D.C., Dole-Olivier M.J., Malard F., Christman M.C., Deharveng L. Assessing and conserving groundwater biodiversity: synthesis and perspectives. Freshw. Biol. 2009, 54:930-941.
34. Gibert J., Danielopol D.L., Stanford J.A. Groundwater ecology. Hydrobiologia 1995, 315:237-242.
35. Gupta P., Mathur N., Bhatnagar P., Nagar P., Srivastava S. Genotoxicity evaluation of hospital wastewaters. Ecotoxicol. Environ. Saf. 2009, 72:1925-1932.
36. Halling-Sørensen B., Holten Lutzhoft H.-C., Andersen H.R., Ingerslev F. Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin. J. Antimicrob. Chemother. 2000, 46:53-58.
37. Halling-Sørensen B., Nors Nielsen S., Lanzky P.F., Ingerslev F., Holten Lützhøft H.C., Jørgensen S.E. Occurrence, fate and effects of pharmaceutical substances in the environment - a review. Chemosphere 1998, 36:357-393.
38. Han G.H., Hur H.G., Kim S.D. Ecotoxicological risk of pharmaceuticals from wastewater treatment plants in Korea: occurrence and toxicity to Daphnia magna. Environ. Toxicol. Chem. 2006, 25:265-271.
39. Ikbal M., Dogan H., Odabas H., Pirim I. Genotoxic evaluation of the antibacterial drug Ciprofloxacin in cultured lymphocytes of patients with urinary tract infection. Turk. J. Med. Sci. 2004, 34:309-313.
40. Isidori M., Lavorgna M., Nardelli A., Parrella A. Toxicity identification evaluation of leachates from municipal solid waste landfills: a multispecies approach. Chemosphere 2003, 52:85-94.
41. Jolibois B., Guerbet M., Vassal S. Glutaraldehyde in hospital wastewater. Arch. Environ. Contam. Toxicol. 2002, 42:137-144.
42. Juvonen R., Martikainen E., Schultz E., Joutti A., Ahtiainen J., Lehtokari M. A battery of toxicity tests as indicators of decontamination in composting oily waste. Ecotoxicol. Environ. Safe. 2000, 47:156-166.
43. Kienzler A., Tronchere X., Devaux A., Bony S. Assessment of RTG-W1, RTL-W1, and PLHC-1 fish cell lines for genotoxicity testing of environmental pollutants by means of a Fpg-modified comet assay. Toxicol. In Vitro 2012, 26:500-510.
44. Kim Y., Choi K., Jung J., Park S., Kim P.-G., Park J. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ. Int. 2007, 33:370-375.
45. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources - a review. Chemosphere 2001, 45:957-969.
46. Kümmerer K., Erbe T., Gartiser S., Brinker L. AOX - Emissions from hospitals into municipal waste water. Chemosphere 1998, 36:2437-2445.
47. Kümmerer K., Helmers E. Hospital effluents as a source of gadolinium in the aquatic environment. Environ. Sci. Technol. 2000, 34:573-577.
48. Laber J. Two-stage constructed wetland for treating hospital wastewater in nepal. Water Sci. Technol. 1999, 40:317-324.
49. Langford K.H., Thomas K.V. Determination of pharmaceutical compounds in hospital effluents and their contribution to wastewater treatment works. Environ. Int. 2009, 35:766-770.
50. Liliburne, L., Phillips, C., 2011. Risk Assessment for Contaminated Sites in New Zealand. <>. http://www.contamsites.landcareresearch.co.nz.
51. Naudin S., Garric J., Vindimian E., Bray M., Migeon B., Vollat B., Lenon G. Influence of the sample preservation mode to assess the chronic toxicity of an industrial effluent. Ecotoxicol. Environ. Safe. 1995, 30:54-62.
52. Ort C., Lawrence M.G., Reungoat J., Eaglesham G., Carter S., Keller J. Determining the fraction of pharmaceutical residues in wastewater originating from a hospital. Water Res. 2010, 44:605-615.
53. Pandard P., Devillers J., Charissou A.-M., Poulsen V., Jourdain M.-J., Férard J.-F., Grand C., Bispo A. Selecting a battery of bioassays for ecotoxicological characterization of wastes. Sci. Total Environ. 2006, 363:114-125.
54. Panouillères M., Boillot C., Perrodin Y. Study of the combined effects of a peracetic acid-based disinfectant and surfactants contained in hospital effluents on Daphnia magna. Ecotoxicology 2007, 16:327-340.
55. Parolini M., Binelli A., Cogni D., Riva C., Provini A. An in vitro biomarker approach for the evaluation of ecotoxicity of non-steroidal anti-inflamatory drugs (NSAIDs). Toxicol. In Vitro 2009, 23:935-942.
56. Perrodin Y., Babut M., Bedell J.P., Bray M., Clement B., Delolme C., Devaux A., Durrieu C., Garric J., Montuelle B. Assessment of ecotoxicological risks related to depositing dredged materials from canals in northern France on soil. Environ. Int. 2006, 32:804-814.
57. Perrodin Y., Boillot C., Angerville R., Donguy G., Emmanuel E. Ecological risk assessment of urban and industrial systems: a review. Sci. Total Environ. 2011, 409:5162-5176.
58. Perrodin Y., Grelier-Volatier L., Barna R., Gobbey A. Assessment of the ecocompatibility of waste disposal or waste use scenarios: towards the elaboration and implementation of a comprehensive methodology. Waste Manag. Ser. 2000, 1:504-512.
59. Persoone, G., Goyvaerts, M., Janssen, C., De Coen, W., Vangheluwe, M., 1993. Cost-effective acute hazard monitoring of polluted waters and waste dumps with the aid of toxkits. Final Report. Contract ACE 89/BE 2/D3. Commission of the European Communities, p. 142.
60. Persoone G., Marsalek B., Blinova I., Torokne A., Zarina D., Manusadzianas L., Nalecz-Jawecki G., Tofan L., Stepanova N., Tothova L., Kolar B. A practical and user-friendly toxicity classification system with microbiotests for natural waters and wastewaters. Environ. Toxicol. 2003, 18:395-402.
61. Radix P., Léonard M., Papantoniou C., Roman G., Saouter E., Gallotti-Schmitt S., Thiébaud H., Vasseur P. Comparison of four chronic toxicity tests using algae, bacteria, and invertebrates assessed with sixteen chemicals. Ecotoxicol. Environ. Safe. 2000, 47:186-194.
62. Ren S., Frymier P.D. Use of multidimensional scaling in the selection of wastewater toxicity test battery components. Water Res. 2003, 37:1655-1661.
63. Rojícková-Padrtová R., MarIsálek B., Holoubek I. Evaluation of alternative and standard toxicity assays for screening of environmental samples: selection of an optimal test battery. Chemosphere 1998, 37:495-507.
64. Santos J.L., Aparicio I., Alonso E. Occurrence and risk assessment of pharmaceutically active compounds in wastewater treatment plants. A case study: Seville city (Spain). Environ. Int. 2007, 33:596-601.
65. Schaefer M. Assessing 2,4,6-trinitrotoluene (TNT)-contaminated soil using three different earthworm test methods. Ecotoxicol. Environ. Safe. 2004, 57:74-80.
66. Schirmer K. Proposal to improve vertebrate cell cultures to establish them as substitutes for the regulatory testing of chemicals and effluents using fish. Toxicology 2006, 224:163-183.
67. Schulz S., Hahn H.H. Der Kanal als Reaktor: Untersuchungen zur AOX-Bildung durch Wirkstoffe in Reinigungsmitteln = The sewer as a reactor: Investigations on the formation of AOX by disinfecting agents. Das Gas- Und Wasserfach Wasser Abwasser 1997, 138:109-120.
68. Sim W.-J., Lee J.-W., Lee E.-S., Shin S.-K., Hwang S.-R., Oh J.-E. Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures. Chemosphere 2011, 82:179-186.
69. Sim W.-J., Lee J.-W., Shin S.-K., Song K.-B., Oh J.-E. Assessment of fates of estrogens in wastewater and sludge from various types of wastewater treatment plants. Chemosphere 2011, 82(82):1448-1453.
70. SIPIBEL, 2011. Research program on hospital wastewater - experimental site of bellecombe. Syndicat Intercommunal de Bellecombe, France. p. 65.
71. Skutlarek, D., Färber, H., 2003. Occurrence of antibiotics in hospital wastewater, municipal wastewater and surface waters. Wissenschaftliches Programm, 55. DGHM-Tagung 29. September-1. Oktober, Dresden, Germany.
72. Sprehe M., Gei en S.-U., Vogelpohl A. Treat of AOX-containing wastewater from hospital - degradation of iodized X-ray contrast medium. Korrespondenz Abwasser 1999, 46:548-558.
73. Sprehe M., Geißen S.-U., Vogelpohl A. Photochemical oxidation of iodized X-ray contrast media (XRC) in hospital wastewater. Water Sci. Technol. 2001, 44:317-323.
74. Steger-Hartmann T., Lange R., Schweinfurth H. Environmental risk assessment for the widely used iodinated X-ray contrast agent iopromide (ultravist). Ecotoxicol. Environ. Safe. 1999, 42:274-281.
75. Suter G.W. Environmental Risk Assessment 1993, Lewis Publishers, Chelsea, p. 550.
76. Theodorakis C.W. Integration of genotoxic and population genetic endpoints in biomonitoring and risk assessment. Ecotoxicology 2001, 10:245-256.
77. UBA, 2011. Compilation of monitoring data on environmental concentrations of pharmaceuticals (Zusammenstellung von Monitoringdaten zu Umweltkonzentrationen von Arzneimitteln). <>. http://www.umweltdaten.de/publikationen/fpdf-l/4188.pdf.
78. US-EPA, 1992. Framework for ecological risk assessment. Risk Assessment Forum. EPA/630/R-92/001, Washington, DC, p. 161.
79. US-EPA, Office of Water Regulations and Standards, 1989. Preliminary data summary for the hospitals point-source category, p. 79.
80. US EPA Preliminary data summary for the hospitals point source category 1989, United States Environmental Protection Agency, Office of water regulation and standards office of water, Washington.
81. Us E.P.A. Guidelines for Ecological Risk Assessment 1998, United States Environmental Protection Agency, Washington, p. 188.
82. Würgler F.E., Kramers P.G.N. Environmental effects of genotoxins (eco-genotoxicology). Mutagenesis 1992, 7:321-327.
83. Zounkovà R., Hilscherovà K., Blàha L., Houloubek I. Evaluation of ecotoxicity and genotoxixity of special (hospital) wastewaters (Poster) 2006, SETAC Europe, Den Haag.