Determination of antibiotics in sewage from hospitals, nursery and slaughter house, wastewater treatment plant and source water in Chongqing region of Three Gorge Reservoir in China

Environmental Pollution

Volumn 158, Issue 5, 2010, Pages 1444-1450

  Chang, Xiaosong ^a   Meyer, Michael T ^b   Liu, Xiaoyun ^c   Zhao, Qing ^a   Chen, Hao ^a   Chen, Ji an ^a   Qiu, Zhiqun ^a   Yang, Lan ^a   Cao, Jia ^a   Shu, Weiqun ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b U S GEOLOGICAL SURVEY   (United States)

^c Lanzhou Command Center for Disease Prevention and Control   (China)

Author keywords

Antibiotics; China; Liquid chromatography electrospray ionization tandem mass spectrometry (LC ESI MS MS); Solid phase extraction (SPE); Three Gorge Reservoir

Indexed keywords

CHINA; LC/ESI-MS/MS; SOLID-PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; THREE GORGE RESERVOIR;

ANTIBIOTICS; HOSPITALS; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PARTICLE DETECTORS; PETROLEUM RESERVOIR EVALUATION; REMOVAL; RESERVOIRS (WATER); SEWAGE; SEWAGE PUMPING PLANTS; SEWAGE TREATMENT; SOLAR RADIATION; SOLVENT EXTRACTION; SULFUR COMPOUNDS; THERMOMECHANICAL PULPING PROCESS; WASTEWATER; WASTEWATER RECLAMATION; WASTEWATER TREATMENT; WATER TREATMENT PLANTS;

WATER RECYCLING;

ANTIBIOTIC AGENT; CIPROFLOXACIN; DRINKING WATER; LINCOSAMIDE; MACROLIDE; NORFLOXACIN; OFLOXACIN; OXYTETRACYCLINE; QUINOLONE DERIVATIVE; SULFONAMIDE; TETRACYCLINE; TRIMETHOPRIM; TYLOSIN;

ANTIBIOTICS; HOSPITAL SECTOR; LIQUID CHROMATOGRAPHY; SEWAGE; SEWAGE TREATMENT; WATER QUALITY;

ACTIVATED SLUDGE; AQUATIC ENVIRONMENT; ARTICLE; CHINA; CONTROLLED STUDY; HOSPITAL WASTE; LIQUID CHROMATOGRAPHY; SLAUGHTERHOUSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; WASTE COMPONENT REMOVAL; WASTE WATER TREATMENT PLANT; WATER ANALYSIS; WATER CONTAMINATION; WATER SAMPLING; WATER SUPPLY;

ANTI-BACTERIAL AGENTS; CHINA; MEDICAL WASTE; SEWAGE; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION;

CHINA; CHONGQING; THREE GORGES RESERVOIR;

EID: 77950296297     PISSN: 02697491     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.envpol.2009.12.034     Document Type: Article

References (37)

1. Alder, A.C., McArdell, C.S., Golet, E.M., Molnar, E.M., Kuch, H.M., Giger, W., 2003. Environmental exposure of antibacterial agents in hospital and municipal wastewater and river water in Switzerland [Abs.]. In: Proceedings of 3rd International Conference on Pharmaceuticals and Endocrine Disrupting Chemicals in Water, 19-21 March 2003, Minneapolis, MN, pp. 236-237.
2. Alder A.C., McArdell C.S., Golet E.M., Kohler H.-P.E., Molnar E., Pham Thi N.A., Siegrist H., Suter M.J.F., and Giger W. Environmental exposure of antibiotics in wastewaters, sewage sludges and surface waters. In: Kümmerer K. (Ed). Pharmaceuticals in the Environment - Sources, Fate, Effects and Risks (2004), Springer, Berlin, Heidelberg, New York 55-66
3. Angela L.B., Ian B.B., and Diana S.A. Evaluating the vulnerability of surface waters to antibiotic contamination from varying wastewater treatment plant discharges. Environ. Pollut. 142 (2006) 295-302
4. Batt A.L., Kim S., and Aga D.S. Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations. Chemosphere 68 (2007) 428-435
5. Costanzo S.D., Murby J., and Bates J. Ecosystem response to antibiotics entering the aquatic environment. Mar. Pollut. Bull. 51 (2004) 218-223
6. Daughton C.G., and Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health Perspect 107 (1999) 907-937
7. Giger W., Alder A.C., Golet E.M., Kohler H.P.E., McArdell C.S., and Molnar E. Occurrence and fate of antibiotics as trace contaminants in wastewaters, sewage sludges, and surface waters. Chimia 57 (2003) 485-491
8. Golet E.M., Alder A.C., and Giger W. Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed. Switzerland. Environ. Sci. Technol 36 (2002) 3645-3651
9. Golet E.M., Xifra I., Siegrist H., Alder A.C., and Giger W. Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil. Environ. Sci. Technol. 37 (2003) 3243-3249
10. Hartmann A., Alder A.C., Koller T., and Widmer R.M. Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater. Environ. Toxicol. Chem. 17 (1998) 377-382
11. Hartmann A., Golet E.M., Gartiser S., Alder A.C., Koller T., and Widmer R.M. Primary DNA damage but not mutagenicity correlates with ciprofloxacin concentrations in German hospital wastewaters. Arch. Environ. Contam. Toxicol 36 (1999) 115-119
12. Hao C., Lissemore L., Nguyen B., Kleywegt S., Yang P., and Solomon K. Determination of pharmaceuticals in environmental waters by liquid chromatography/electrospray ionization/ tandem mass spectrometry. Anal. Bioanal. Chem. 384 (2006) 505-513
13. Hirsch R., Ternes T., Haberer K., and Kratz K.L. Occurrence of antibiotics in the aquatic environment. Sci. Total Environ. 225 (1999) 109-118
14. Hong A.D., Ngoc H.P., Hoang T.N., Thi T.H., Hung V.P., Van C.P., Michael B., Walter G., and Alfredo C.A. Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam. Chemosphere 72 (2008) 968-973
15. Huang C.H., and Sedlak D.L. Analysis of estrogenic hormones in municipal wastewater effluent and surface water using enzyme-linked immunosorbent assay and gas chromatography/ tandem mass spectrometry. Environ. Toxicol. Chem. 20 (2001) 133-139
16. Kathryn D.B., Jerzy K., Bruce T., Timothy H.C., and Douglas B.M. Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Sci. Total Environ. 366 (2005) 772-783
17. Kemper N. Veterinary antibiotics in the aquatic and terrestrial environment. Ecol. Indic. 8 (2008) 1-13
18. Kim S., Eichhorn P., Jensen J.N., Weber A.S., and Aga D.S. Removal of antibiotics in wastewater: effect of hydraulic and solid retention times on the fate of tetracycline in the activated sludge process. Environ. Sci. Technol. 39 (2005) 5816-5823
19. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., and Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol 36 (2002) 1202-1211
20. Kümmerer K. Antibiotics in the aquatic environment. Part I. Chemosphere 75 (2009) 417-434
21. Kümmerer K., Al-Ahmad A., and Mersch-Sundermann V. Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test. Chemosphere 40 (2000) 701-710
22. Kümmerer K., and Henninger A. Promoting resistance by the emission of antibiotics from hospitals and households into effluent. Clin. Microbiol. Infect. 9 (2003) 1203-1214
23. Lindberg R.H., Jarnheimer P.A., Olsen B., Johansson M., and Tysklind M. Determination of antibiotic substances in hospital sewage water using solid phase extraction and liquid chromatography/mass spectrometry and group analogue internal standards. Chemosphere 57 (2005) 1479-1488
24. Lindberg R.H., Björklund K., Rendahl P., Johansson M.I., Tysklind M., and Andersson B.A.V. Environmental risk assessment of antibiotics in the Swedish environment with emphasis on sewage treatment plants. Water Res. 41 (2006) 613-619
25. Meyer, M.T., Lee, E.A., Ferrell, G.M., Bumgarner, J.E., Varns, Jerry, 2007. Evaluation of offline tandem and online solid-phase extraction with liquid chromatography/electrospray ionization-mass spectrometry for analysis of antibiotics in ambient water and comparison to an independent method: U.S. Geological Survey Scientific Investigations Report 2007-5021, 28 p.
26. Obst U., Schwartz T., and Volkmann H. Antibiotic resistant pathogenic bacteria and their resistance genes in bacterial biofilms. Int. J. Artif. Organs. 29 (2006) 387-394
27. Ohlsen K., Ternes T., Werner G., Wallner U., Loffler D., Ziebuhr W., Witte W., and Hacker J. Impact of antibiotics on conjugational resistance gene transfer in Staphylococcus aureus in sewage. Environ. Microbiol. 5 (2003) 711-716
28. Osman A.A., Clifford R., and Eaton C. Occurrence of antibiotics and hormones in a major agricultural watershed. Desalination 226 (2008) 121-133
29. Park S., and Choi K. Hazard assessment of commonly used agricultural antibiotics on aquatic ecosystems. Ecotoxicology 17 (2008) 526-538
30. Pomati F., Castiglioni S., Zuccato E., Fanelli R., Vigetti D., Rossetti C., and Davide C. Effects of a complex mixture of therapeutic drugs at environmental levels on human embryonic cells. Environ. Sci. Technol. 40 (2006) 2442-2447
31. Richardson B.J., Lam P.K.S., and Martin M. Emerging chemicals of concern: pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China. Mar. Pollut. Bull. 50 (2005) 913-920
32. Roberts P.H., and Thomas K.V. The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment. Sci. Total Environ. 356 (2006) 143-153
33. Sendzik J., Shakibaei M., Schafer-Korting M., and Stahlmann R. Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells. Toxicology 212 (2005) 24-36
34. Stackelberg P.E., Furlong E.T., Meyer M.T., Zaugg S.D., Henderson A.K., and Reissman D.B. Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking water-treatment plant. Sci. Total Environ. 329 (2004) 99-113
35. Stolker A., Niesing W., Hogendoorn E.A., Versteegh J.F.M., Fuchs R., and Brinkman U.A.T. Liquid chromatography with triple-quadrupole or quadrupole-time of flight mass spectrometry for screening and confirmation of residues of pharmaceuticals in water. Anal. Bioanal. Chem. 378 (2004) 955-963
36. Sukul P., Lamshoft M., Zühlke S., and Spiteller M. Photolysis of C sulfadiazine in water and manure. Chemosphere 71 (2008) 717-725
37. Xu W.H., Zhang G., Li X.D., Zou S.C., Li P., Hu Z.H., and Li J. Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD), South China. Water Res. 41 (2007) 4526-4534