MC4-R signaling within the nucleus accumbens shell, but not the lateral hypothalamus, modulates ethanol palatability in rats

Behavioural Brain Research

Volumn 239, Issue 1, 2013, Pages 51-54

  Lerma Cabrera, Jose M ^a   Carvajal, Francisca ^a   Chotro, Gabriela ^c   Gaztañaga, Mirari ^c   Navarro, Montserrat ^b   Thiele, Todd E ^b   Cubero, Inmaculada ^a  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Ethanol; Lateral hypothalamus; MC4 receptors; Nucleus accumbens; Palatability; Taste reactivity

Indexed keywords

ALCOHOL; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; SODIUM CHLORIDE;

ALCOHOL CONSUMPTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AVERSION; CONTROLLED STUDY; HORMONE ACTION; LATERAL HYPOTHALAMUS; LIMBIC SYSTEM; MALE; NERVE CELL NETWORK; NEUROMODULATION; NONHUMAN; NUCLEUS ACCUMBENS; PALATABILITY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TASTE DISCRIMINATION;

ALCOHOL DRINKING; ANIMALS; HYPOTHALAMUS; MALE; MICROINJECTIONS; NUCLEUS ACCUMBENS; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 4; SIGNAL TRANSDUCTION; TASTE PERCEPTION;

EID: 84869878641     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.10.055     Document Type: Article

References (25)

1. Adan R.A., Tiesjema B., Hillebrand J.J., la Fleur S.E., Kas M.J., de Krom M. The MC4 receptor and control of appetite. British Journal of Pharmacology 2006, 149:815-827.
2. Vergoni A.V., Bertolini A. Role of melanocortins in the central control of feeding. European Journal of Pharmacology 2000, 405:25-32.
3. Navarro M., Cubero I., Knapp D.J., Thiele T.E. MTII-induced reduction of voluntary ethanol drinking is blocked by pretreatment with AgRP-(83-132). Neuropeptides 2003, 37:338-344.
4. Ploj K., Roman E., Kask A., Hyytia P., Schioth H.B., Wikberg J., Nylander I. Effects of melanocortin receptor ligands on ethanol intake and opioid levels in alcohol-preferring AA rats. Brain Research Bulletin 2002, 59(2):97-104.
5. Navarro M., Cubero I., Chen A.S., Chen H.Y., Knapp D.J., Breese G.R., Marsh D.J., Thiele T.E. Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor. Alcoholism, Clinical and Experimental Research 2005, 29:949-957.
6. Navarro M., Cubero I., Ko L., Thiele T.E. Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice. Genes Brain Behav 2009, 8(4):450-458.
7. Lerma-Cabrera J.M., Carvajal F., de la Torre L., de la Fuente L., Navarro M., Thiele E.T., Cubero I. Control of food intake by MC4-R signaling in the lateral hypothalamus, nucleus accumbens shell and ventral tegmental area: Interactions with ethanol. Behavioural Brain Research 2012, 234:51-60.
8. Grill H.J., Norgren R. The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res 1978, 143(2):263-279.
9. Hill K.G., Sable H.J., Ferraro F.M., Kiefer S.W. Chronic naltrexone treatment and ethanol responsivity in outbred rats. Alcoholism, Clinical and Experimental Research 2010, 34(2):272-279.
10. Diaz-Cenzano E., Chotro M.G. The effect of taste familiarity on intake and taste reactivity in infant rats. Developmental Psychobiology 2010, 52(2):109-120.
11. Cubero I., Thiele T.E., Bernstein I.L. Insular cortex lesions and taste aversion learning: effects of conditioning method and timing of lesion. Brain Research 1999, 839(2):323-330.
12. Paxinos G., Watson C. The rat brain in stereotaxic coordinates, 4th 1998, edic. Academic Press, NY.
13. Kiefer S.W., Hill K.G., Coonfield D.L., Ferraro F.M. Ethanol familiarity and naltrexone treatment affect ethanol responses in rats. Alcohol 2005, 37(3):167-172.
14. Bednarek M.A., MacNeil T., Tang R., Kalyani R.N., Van der Ploeg L.H., Weinberg D.H. Potent and selective peptide agonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro. Biochemical and Biophysical Research Communications 2001, 286:641-645.
15. Zhang M., Kelley A.E. Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens. Psychopharmacol (Berl) 2002, 159:415-423.
16. Kiefer S.W. Alcohol, palatability, and taste reactivity. Neuroscience and Biobehavioral Reviews 1995, 19:133-141.
17. Kiefer S.W., Bice P.J., Badia-Elder N. Alterations in taste reactivity to alcohol in rats given continuous alcohol access followed by abstinence. Alcoholism, Clinical and Experimental Research 1994, 18(3):555-559.
18. Kiefer S.W., Lawrence G.J. The sweet bitter taste of alcohol-aversion generalization to various sweet quinine mixtures in the rat. Chemical Senses 1988, 13(4):633-641.
19. Baldo B.A., Kelley A.E. Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding. Psychopharmacol (Berl) 2007, 191(3):439-459.
20. Berridge K.C. Motivation concepts in behavioral neuroscience. Physiology and Behavior 2004, 81(2):179-209.
21. Fudge M.A., Kavaliers M., Ossenkopp K.P. Allopregnanolone produces hyperphagia by reducing neophobia without altering food palatability. European Neuropsychopharmacology 2006, 16(4):272-280.
22. Coonfield D.L., Hill K.G., Kaczmarek H.J., Ferraro F.M., Kiefer S.W. Low doses of naltrexone reduce palatability and consumption of ethanol in outbred rats. Alcohol 2002, 26(1):43-47.
23. Grossman H.C., Hadjimarkou M.M., Silva R.M., Giraudo S.Q., Bodnar R.J. Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats. Brain Research 2003, 991:240-244.
24. Kalange A.S., Kokare D.M., Singru P.S., Upadhya M.A., Chopde C.T., Subhedar N.K. Central administration of selective melanocortin 4 receptor antagonist HS014 prevents morphine tolerance and withdrawal hyperalgesia. Brain Research 2007, 1181:10-20.
25. Vrinten D.H., Adan R.A., Groen G.J., Gispen W.H. Chronic blockade of melanocortin receptors alleviates allodynia in rats with neuropathic pain. Anesthesia and Analgesia 2001, 93:1572-1577.