Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty

Biotechnology and Bioengineering

Volumn 110, Issue 1, 2013, Pages 206-219

  Pollock, James ^a   Ho, Sa V ^b   Farid, Suzanne S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Antibody production; Biopharmaceutical manufacture; Cell culture; Fed batch; MySQL database; Perfusion; Process economics; Stochastic discrete event simulation

Indexed keywords

AUTOMOBILE MANUFACTURE; BATCH DATA PROCESSING; CELL CULTURE; CONTINUOUS CELL CULTURE; COST BENEFIT ANALYSIS; DECISION MAKING; DECISION SUPPORT SYSTEMS; DISCRETE EVENT SIMULATION; MONOCLONAL ANTIBODIES; MONTE CARLO METHODS; UNCERTAINTY ANALYSIS;

ANTIBODY PRODUCTION; BIOPHARMACEUTICAL MANUFACTURE; DISCRETE EVENTS; FED BATCHES; MYSQL DATABASE; PERFUSION; PROCESS ECONOMICS;

BATCH CELL CULTURE;

ARTICLE; BIOPROCESS; CELL DENSITY; CULTURE TECHNIQUE; DECISION MAKING; ENVIRONMENTAL SUSTAINABILITY; FEASIBILITY STUDY; FED BATCH CULTURE; MONTE CARLO METHOD; PERFUSION CULTURE;

ARANEAE;

EID: 84869877665     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24608     Document Type: Article

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