Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis

Aquatic Toxicology

Volumn 98, Issue 1, 2010, Pages 44-50

  Tietge, Joseph E ^a   Butterworth, Brian C ^a   Haselman, Jonathan T ^a   Holcombe, Gary W ^a   Hornung, Michael W ^a   Korte, Joseph J ^a   Kosian, Patricia A ^a   Wolfe, Marilyn ^b   Degitz, Sigmund J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

Author keywords

6 Propylthiouracil; Methimazole; Perchlorate; Thyroid hormone; Xenopus laevis

Indexed keywords

DIIODOTYROSINE; IODOTYROSINE; PERCHLORATE; PROPYLTHIOURACIL; THIAMAZOLE; THYROID HORMONE; THYROXINE;

BIOASSAY; CELL ORGANELLE; CHEMOSYNTHESIS; CONCENTRATION (COMPOSITION); DRUG; ENDOCRINE DISRUPTOR; FROG; HISTOLOGY; INHIBITION; INHIBITOR; REDUCTION; SEX HORMONE; STEROID;

AMPHIBIA; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL COUNT; CELL HYPERPLASIA; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; GOITER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; INHIBITION KINETICS; MASS SPECTROMETRY; METAMORPHOSIS; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SPECIES DIFFERENCE; THYROID FOLLICLE CELL; THYROID HORMONE SYNTHESIS; XENOPUS LAEVIS;

ANIMALS; ANTITHYROID AGENTS; CELL COUNT; LARVA; METHIMAZOLE; PERCHLORIC ACID; PROPYLTHIOURACIL; THYROID GLAND; THYROID HORMONES; XENOPUS LAEVIS;

AMPHIBIA; XENOPUS LAEVIS;

EID: 77953686592     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2010.01.014     Document Type: Article

References (30)

1. Brown D.D., Cai L. Amphibian metamorphosis. Dev. Biol. 2007, 306:20-33.
2. Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid 1998, 8:827-856.
3. Capen C.C. Mechanisms of chemical injury of thyroid gland. Prog. Clin. Biol. Res. 1994, 387:173-191.
4. Davidson B., Soodak M., Neary J.T., Strout H.V., Kieffer J.D., Mover H., Maloof F. The irreversible inactivation of thyroid peroxidase by methylmercaptoimidazle, thiouracil, and propylthiouracil, in vitro and its relationship to in vivo findings. Endocrinology 1978, 103:871-882.
5. Degitz S.J., Holcombe G.W., Flynn K.M., Kosian P.A., Korte J.J., Tietge J.E. Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis: Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine. Toxicol. Sci. 2005, 87:353-364.
6. DeVito M., Biegel L., Brouwer A., Brown S., Brucker-Davis F., Cheek A.O., Christensen R., Colborn T., Cooke P., Crissman J., Crofton K., Doerge D., Gray E., Hauser P., Hurley P., Kohn M., Lazar J., McMaster S., McClain M., McConnell E., Meier C., Miller R., Tietge J., Tyl R. Screening methods for thyroid hormone disruptors. Environ. Health Perspect. 1999, 107:407-415.
7. Dodd M.H.I., Dodd J.M. The biology of metamorphosis. Physiology of Amphibia 1976, 467-599. Academic Press, New York, NY, USA. B. Lofts (Ed.).
8. Dohan O., De la Vieja A., Paroder V., Riedel C., Artani M., Reed M., Ginter C.S., Carrasco N. The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocr. Rev. 2003, 24:48-77.
9. Engler H., Taurog A., Nakashima T. Mechanism of inactivation of thyroid peroxidase by thioureylene drugs. Biochem. Pharmacol. 1982, 31:3801-3806.
10. Fort D.J., Degitz S., Tietge J., Touart L.W. The hypothalamic-pituitary-thyroid (HPT) axis in frogs and its role in frog development and reproduction. Crit. Rev. Toxicol. 2007, 37:117-161.
11. Goos H.J., De Knecht A., De Vries J. Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. I. The effect of propylthiouracil. Zeitschrift Fur Zellforschung 1968, 86:384-392.
12. Grim K.C., Wolfe M., Braunbeck T., Iguchi T., Ohta Y., Tooi O., Touart L., Wolf D.C., Tietge J.E. Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances. Toxicol. Pathol. 2009, 37:415-424.
13. Hooth M.J., DeAngelo A.B., George M.H., Gaillard E.T., Travlos G.S., Boorman G.A., Wolf D.C. Subchronic sodium chlorate exposure in drinking water results in a concentration-dependent increase in rat thyroid follicular cell hyperplasia. Toxicol. Pathol. 2001, 29:250-259.
14. Iino S., Yamada T., Greer M.A. Effect of graded doses of propylthiouracil on biosynthesis of thyroid hormones. Endocrinology 1961, 68:582-588.
15. Jansen E.H.J.M., Doorn L., VanLeeuwen F.X.R. Determination of proteolytic hydrolysis of thyroglobulin. J. Chromatogr. 1991, 566:471-480.
16. LeLoup J., Buscaglia M. La triiodothyronine, hormone de la metamorphose des Amphibiens. C. R. Acad. Sci. Ser. III Sci. Vie. 1977, 284:2261-2263.
17. Michalke B., Schramel P., Witte H. Method developments for iodine speciation by reversed-phase liquid chromatography-ICP-mass spectrometry. Biol. Trace Elem. Res. 2000, 78:67-79.
18. Nieuwkoop P.D., Faber J. Normal Table of Xenopus laevis (Daudin): A Systematical and Chronological Survey of the Development from the Fertilized Egg till the End of Metamorphosis 1994, Garland, New York, NY, USA. 3rd ed.
19. Nagasaka A., Hidaka H. Effect of antithyroid agents 6-propyl-2-thiouracil and 1-methyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J. Clin. Endocrinol. Metab. 1976, 43:142-158.
20. OECD Test No. 231: Amphibian Metamorphosis Assay, OECD Guidelines for the Testing of Chemicals, Section 2: Effects on Biotic Systems, No. 100 2009, OECD Publishing.
21. Opitz R., Braunbeck T., Bogi C., Pickford D.B., Nentwig G., Oehlmann J., Tooi O., Lutz I., Kloas W. Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid system-disrupting activities of environmental compounds. Environ. Toixol. Chem. 2005, 24:653-664.
22. Opitz R., Schmidt F., Braunbeck T., Wuertz S., Kloas W. Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis. Mol. Cell Endocrinol. 2009, 298:101-114.
23. Richards J.B., Ingbar S. The effects of propylthiouracil and perchlorate on the biogenesis of thyroid hormone. Endocrinology 1959, 65:198-207.
24. Takatera K., Watanabe T. Speciation of iodo amino acids by high-performance liquid chromatography with inductively coupled mass spectrometric detection. Anal. Chem. 1993, 65:759-762.
25. Taurog A. The mechanism of action of the thioureylene antithyroid drugs. Endocrinology 1976, 98:1031-1046.
26. Tietge J.E., Holcombe G.W., Flynn K.M., Kosian P.A., Korte J.J., Anderson L.E., Wolf D.C., Degitz S.J. Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology. Environ. Toxicol. Chem. 2005, 24:926-933.
27. U.S. Environmental Protection Agency, 1998. Endocrine disruptor screening and Testing Advisory Committee. Final report. EPA/743/R-98/003. Washington, DC.
28. van Sande J., Massart C., Beauwens R., Schoutens A., Costagliola S., Dumont J.E., Wolff J. Anion selectivity by the sodium iodide symporter. Endocrinology 2003, 144:247-252.
29. Wolff J. Perchlorate and the thyroid gland. Pharmacol. Rev. 1998, 50:89-105.
30. Zoeller R.T., Tan S.W. Implications of research on assays to characterize thyroid toxicants. Crit. Rev. Toxicol. 2007, 37:195-210.