Evaluation of protective effect of DNA vaccines encoding the BAB1_0263 and BAB1_0278 open reading frames of Brucella abortus in BALB/c mice

Vaccine

Volumn 30, Issue 50, 2012, Pages 7286-7291

  Sislema Egas, Fernanda ^a   Céspedes, Sandra ^a   Fernández, Pablo ^a   Retamal Díaz, Angello ^a   Sáez, Darwin ^a   Oñate, Angel ^a  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

BAB1_0263; BAB1_0278; Brucella abortus; Brucellosis; DNA vaccine; Genomic Island 3 (GI 3); Immune response; Protection

Indexed keywords

BRUCELLA VACCINE; DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 4;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BRUCELLA ABORTUS; BRUCELLA MELITENSIS; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA IMMUNIZATION; FEMALE; GENOMIC ISLAND; HUMORAL IMMUNITY; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BRUCELLA ABORTUS; BRUCELLA MELITENSIS; BRUCELLA VACCINE; BRUCELLOSIS; CELL PROLIFERATION; FEMALE; IMMUNOGLOBULIN G; INTERFERON-GAMMA; MICE; MICE, INBRED BALB C; OPEN READING FRAMES; T-LYMPHOCYTES; TH1 CELLS; VACCINES, DNA;

EID: 84869875700     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.09.039     Document Type: Article

References (32)

1. Corbel M.J. Brucellosis: an overview. Emerg Infect Dis 1997, 3:213-221.
2. Carvalho Neta A.V., Mol J.P.S., Xavier M.N., Paixão T.A., Lage A.P., Santos R.L. Pathogenesis of bovine brucellosis. Vet J 2010, 184:146-155.
3. Oliveira S.C., Soeurt N., Splitter G. Molecular and cellular interactions between Brucella abortus antigens and host immune responses. Vet Microbiol 2002, 90:417-424.
4. Berkelman R.L. Human illness associated with use of veterinary vaccines. Clin Infect Dis 2003, 37:407-414.
5. Oliveira S.C., Macedo G.C., Almeida L.A.D., Oliveira F.S.D., Oñate A., Cassataro J., et al. Recent advances in understanding immunity against brucellosis: application for vaccine development. Open Vet Sci J 2010, 4:102-108.
6. Luo D., Ni B., Li P., Shi W., Zhang S., Han Y., et al. Protective immunity elicited by a divalent DNA vaccine encoding both the L7/L12 and Omp16 genes of Brucella abortus in BALB/c mice. Infect Immun 2006, 74:2734-2741.
7. Al-Mariri A., Tibor A., Mertens P., De Bolle X., Michel P., Godfroid J., et al. Induction of immune response in BALB/c mice with a DNA vaccine encoding bacterioferritin or P39 of Brucella spp. Infect Immun 2001, 69:6264-6270.
8. Velikovsky C.A., Cassataro J., Giambartolomei G.H., Goldbaum F.A., Estein S., Bowden R.A., et al. A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB/c mice. Infect Immun 2002, 70:2507-2511.
9. Cassataro J., Velikovsky C.A., Bruno L., Estein S.M., de la Barrera S., Bowden R., et al. Improved immunogenicity of a vaccination regimen combining a DNA vaccine encoding Brucella melitensis outer membrane protein 31 (Omp31) and recombinant Omp31 boosting. Clin Vaccine Immunol 2007, 14:869-874.
10. Oñate A., Céspedes S., Cabrera A., González A., Muñoz C., Folch H., et al. A DNA vaccine encoding Cu, Zn superoxide dismutase of Brucella abortus induces protective immunity in BALB/c mice. Infect Immun 2003, 71:4857-4861.
11. He Y., Xiang Z. Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN. Immunome Res 2010, 6(Suppl. 1):S5.
12. Hacker J., Carniel E. Ecological fitness, genomic islands and bacterial pathogenicity. A Darwinian view of the evolution of microbes. EMBO Rep 2001, 2:376-381.
13. Rajashekara G., Glasner J.D., Glover D.A., Splitter G.A. Comparative whole-genome hybridization reveals genomic islands in Brucella species. J Bacteriol 2004, 186:5040-5051.
14. Céspedes S., Salgado P., Valenzuela P., Vidal R., Oñate A. Characterization of genomic island 3 and genetic variability of Chilean field strains of Brucella abortus. J Clin Microbiol 2011, 49:2461-2469.
15. Céspedes S., Salgado P., Retamal-Díaz A., Vidal R., Oñate A. Roles of genomic island 3 (GI-3) BAB1_0278 and BAB1_0263 open reading frames (ORFs) in the virulence of Brucella abortus in BALB/c mice. Vet Microbiol 2011, 156:1-7.
16. Juhas M., van der Meer J.R., Gaillard M., Harding R.M., Hood D.W., Crook D.W. Genomic islands: tools of bacterial horizontal gene transfer and evolution. FEMS Microbiol Rev 2009, 33:376-393.
17. Gordon B.R.G., Li Y., Wang L., Sintsova A., van Bakel H., Tian S., et al. Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2010, 107:5154-5159.
18. Park K.T., Dahl J.L., Bannantine J.P., Barletta R.G., Ahn J., Allen A.J., et al. Demonstration of allelic exchange in the slow-growing bacterium Mycobacterium avium subsp. paratuberculosis, and generation of mutants with deletions at the pknG, relA, and lsr2 loci. Appl Environ Microbiol 2008, 74:1687-1695.
19. Wong D.K., Lee B.Y., Horwitz M.A., Gibson B.W. Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry. Infect Immun 1999, 67:327-336.
20. Brilli M., Fondi M., Fani R., Mengoni A., Ferri L., Bazzicalupo M., et al. The diversity and evolution of cell cycle regulation in alpha-proteobacteria: a comparative genomic analysis. BMC Syst Biol 2010, 4:52.
21. Kaushik P., Singh D.K., Kumar S.V., Tiwari A.K., Shukla G., Dayal S., et al. Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides. Vet Res Commun 2010, 34:119-132.
22. Oñate A., Andrews E., Beltran A., Eller G., Schurig G., Folch H. Frequent exposure of mice to crude Brucella abortus proteins down-regulates immune response. J Vet Med B Infect Dis Vet Public Health 2000, 47:677-682.
23. Oñate A., Céspedes S., Cabrera A., Rivers R., González A., Muñoz C., et al. A DNA vaccine encoding Cu, Zn superoxide dismutase of Brucella abortus induces protective immunity in BALB/c mice. Infect Immun 2003, 71:4857-4861.
24. Cassataro J., Velikovsky C.A., de la Barrera S., Estein S.M., Bruno L., Bowden R., et al. A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response. Infect Immun 2005, 73:6537-6546.
25. Munoz-Montesino C., Andrews E., Rivers R., Gonzalez-Smith A., Moraga-Cid G., Folch H., et al. Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells. Infect Immun 2004, 72:2081-2087.
26. Rosinha G.M.S., Myioshi A., Azevedo V., Splitter G.A., Oliveira S.C. Molecular and immunological characterisation of recombinant Brucella abortus glyceraldehyde-3-phosphate-dehydrogenase, a T- and B-cell reactive protein that induces partial protection when co-administered with an interleukin-12-expressing plasmid in a DNA. J Med Microbiol 2002, 51:661-671.
27. Leclerq S., Harms J.S., Rosinha G.M.S., Azevedo V., Olveira S.C. Induction of a Th1-type of immune response but not protective immunity by intramuscular DNA immunization with Brucella abortus GroEL heat-shock gene. J Med Microbiol 2002, 51:20-26.
28. Vemulapalli R., He Y., Boyle S.M., Sriranganathan N., Schurig G.G. Brucella abortus strain RB51 as a vector for heterologous protein expression and induction of specific Th1 type immune responses. Infect Immun 2000, 68:3290-3296.
29. Hassett D.E., Zhang J., Whitton J.L. Plasmid DNA vaccines are effective in the absence of IFNgamma. Virology 1999, 263:175-183.
30. Yoshida A., Nagata T., Uchijima M., Koide Y. Protective CTL response is induced in the absence of CD4+ T cells and IFN-gamma by gene gun DNA vaccination with a minigene encoding a CTL epitope of Listeria monocytogenes. Vaccine 2001, 19:4297-4306.
31. Sojka D., Fowell D.J. Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10. Proc Natl Acad Sci USA 2011, 108:18336-18341.
32. Grivennikov S.I., Tumanov A.V., Liepinsh D.J., Kruglov A.A., Marakusha B.I., Shakhov A.N., et al. Distinct and nonredundant in vivo functions of TNF produced by T cells and macrophages/neutrophils: protective and deleterious effects. Immunity 2005, 22:93-104.