Fluoroquinolone photodegradation influences specific basophil activation

International Archives of Allergy and Immunology

Volumn 160, Issue 4, 2013, Pages 377-382

  Mayorga, Cristobalina ^a,b   Andreu, Inmaculada ^d   Aranda, Ana ^a   Doña, Inmaculada ^c   Montañez, M Isabel ^a   Blanca Lopez, Natalia ^e   Ariza, Adriana ^a   Nuin, Edurne ^d   Blanca, Miguel ^c   Miranda, Miguel A ^d   Torres, M Jose ^c  

^a Research Laboratory   (Spain)

^b Pediatric Service   (Spain)

^c HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^d CSIC   (Spain)

^e HOSPITAL UNIVERSITARIO INFANTA LEONOR   (Spain)

Author keywords

Allergy; Basophil activation; Hapten protein conjugates; Immunoglobulin E; Photodegradation; Quinolones

Indexed keywords

CIPROFLOXACIN; IMMUNOGLOBULIN E; MOXIFLOXACIN;

ANAPHYLACTIC SHOCK; ANAPHYLAXIS; ARTICLE; BASOPHIL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG HYPERSENSITIVITY; FLUORESCENCE; HUMAN; LEUKOCYTE ACTIVATION; LIGHT EXPOSURE; MOLECULAR WEIGHT; PHOTODEGRADATION; PRIORITY JOURNAL; URTICARIA; ABSORPTION SPECTROPHOTOMETRY; ADULT; AGED; ALLERGY TEST; BASOPHIL ACTIVATION TEST; DARKNESS; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AZA COMPOUNDS; BASOPHILS; CIPROFLOXACIN; FLUOROQUINOLONES; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; LIGHT; MIDDLE AGED; PHOTOLYSIS; QUINOLINES; YOUNG ADULT;

EID: 84869868846     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000343023     Document Type: Article

References (12)

1. Albini A, Monti S: Photophysics and photochemistry of fluoroquinolones. Chem Soc Rev 2003; 32: 238-250.
2. Belvedere A, Boscá F, Cuquerella MC, de Guidi G, Miranda MA: Photoinduced N- demethylation of rufloxacin and its methyl ester under aerobic conditions. Photochem Photobiol 2002; 76: 252-258.
3. Dawe RS, Ibbotson SH, Sanderson JB, Thomson EM, Ferguson J: A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity. Br J Dermatol 2003; 149: 1232-1241.
4. Hayashi N, Nakata Y, Yazaki A: New findings on the structure- phototoxicity relationship and photostability of fluoroquinolones with various substituents at position 1. Antimicrob Agents Chemother 2004; 48: 799-803.
5. Van Bambeke F, Tulkens PM: Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes. Drug Safety 2009; 32: 359-378.
6. Sachs B, Riegel S, Seebeck J, Beier R, Schichler D, Barger A, Merk HF, Erdmann S: Fluoroquinolone- associated anaphylaxis in spontaneous adverse drug reaction reports in Germany: differences in reporting rates between individual fluoroquinolones and occurrence after first-ever use. Drug Saf 2006; 29: 1087-1100.
7. Manfredi M, Severino M, Testi S, Macchia D, Ermini G, Pichler WJ, Campi P: Detection of specific IgE to quinolones. J Allergy Clin Immunol 2004; 113: 155-160.
8. Aranda A, Mayorga C, Ariza A, Doña I, Rosado A, Blanca-Lopez N, Andreu I, Torres MJ: In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones. Allergy 2011; 66: 247-254.
9. Andreu I, Mayorga C, Miranda MA: Generation of reactive intermediates in photoallergic dermatitis. Curr Opin Allergy Clin Immunol 2010; 10: 303-308.
10. Antunez C, Fernandez T, Blanca-Lopez N, Torres MJ, Mayorga C, Canto G, Fernández J, Moya MC, Blanca M: IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response. Allergy 2006; 61: 940-946.
11. Torres MJ, Ariza A, Mayorga C, Doña I, Blanca-Lopez N, Rondon C, Blanca M: Clavulanic acid can be the component in amoxicillin- clavulanic acid responsible for immediate hypersensitivity reactions. J Allergy Clin Immunol 2010; 125: 502-505.
12. Torres MJ, Blanca M: The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams. Med Clin North Am 2010; 94: 805-820.