Aggregation analysis of pharmaceutical human immunoglobulin preparations using size-exclusion chromatography and analytical ultracentrifugation sedimentation velocity

Journal of Bioscience and Bioengineering

Volumn 115, Issue 1, 2013, Pages 104-110

  Krayukhina, Elena ^a   Uchiyama, Susumu ^a   Nojima, Kiyoko ^b   Okada, Yoshiaki ^b   Hamaguchi, Isao ^b   Fukui, Kiichi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Analytical ultracentrifugation sedimentation velocity; Gaussian skim; Immunoglobulin; Size exclusion chromatography; Vertical drop method

Indexed keywords

ALTERNATIVE METHODS; ANALYTICAL ULTRACENTRIFUGATION; CHROMATOGRAPHIC DATA; COMPOSITION ANALYSIS; GAUSSIANS; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN; INTEGRATION APPROACH; INTEGRATION METHOD; ORTHOGONAL METHOD; PHARMACEUTICAL FORMULATION; PHARMACEUTICAL INDUSTRY; PHARMACEUTICAL PREPARATIONS; PROTEIN AGGREGATION; QUANTITATIVE INTERPRETATION; SEC ANALYSIS; SEDIMENTATION VELOCITIES; SOLUBLE AGGREGATES; TOKYO , JAPAN; VERTICAL DROPS;

AGGREGATES; CENTRIFUGATION; DROPS; GAUSSIAN DISTRIBUTION; INTEGRATION; MEASUREMENTS; SEDIMENTS;

SIZE EXCLUSION CHROMATOGRAPHY;

HEBSBULIN; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; SANGLOPOR; TETANUS ANTIBODY; UNCLASSIFIED DRUG;

ANALYTICAL ULTRACENTRIFUGATION SEDIMENTATION VELOCITY; ARTICLE; COMPUTER PROGRAM; GEL PERMEATION CHROMATOGRAPHY; IMMUNOGLOBULIN AGGREGATE; QUANTITATIVE ANALYSIS; VELOCITY;

CHROMATOGRAPHY, GEL; FREEZE DRYING; HUMANS; IMMUNOGLOBULINS; REPRODUCIBILITY OF RESULTS; SOFTWARE; ULTRACENTRIFUGATION;

EID: 84869867106     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2012.07.021     Document Type: Article

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