A bayesian approach for quantifying trace amounts of antibody aggregates by sedimentation velocity analytical ultracentrifugation

AAPS Journal

Volumn 10, Issue 3, 2008, Pages 481-493

  Brown, Patrick H ^a   Balbo, Andrea ^a   Schuck, Peter ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

Analytical ultracentrifugation; Bayesian analysis; Hydrodynamic separation; Sedimentation velocity; Size distribution; Trace aggregates

Indexed keywords

ANTIBODY; MONOMER; OLIGOMER;

ACCURACY; ARTICLE; BAYES THEOREM; COMPUTER SIMULATION; CONTROLLED STUDY; ENTROPY; QUANTITATIVE ANALYSIS; RELIABILITY; SEDIMENTATION; ULTRACENTRIFUGATION;

ANTIBODIES, MONOCLONAL; BAYES THEOREM; BIOPHARMACEUTICS; COMPUTER SIMULATION; IMMUNOGLOBULIN G; MODELS, THEORETICAL; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; THERMODYNAMICS; ULTRACENTRIFUGATION;

EID: 57149088448     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-008-9058-z     Document Type: Article

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