Influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes

Internal Medicine

Volumn 51, Issue 22, 2012, Pages 3109-3113

  Fang, Fu Sheng ^a   Li, Zhi Bing ^a   Li, Chun Lin ^a   Tian, Hui ^a   Li, Jian ^a   Cheng, Xiao Ling ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Glycemic variability; HbA1c; Type 2 diabetes

Indexed keywords

CHOLESTEROL; GLUCOSE OXIDASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

AGED; ARTICLE; BLOOD GLUCOSE MONITORING; CROSS-SECTIONAL STUDY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GLYCEMIC VARIABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; QUESTIONNAIRE; RISK;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; BLOOD GLUCOSE SELF-MONITORING; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE;

EID: 84869836677     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.51.8077     Document Type: Article

References (17)

1. Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China. N Engl J Med 362: 1090-1101, 2010.
2. Gunasekaran U, Gannon M. Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) 3: 565-575, 2011.
3. Kohnert KD, Augstein P, Zander E, et al. Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents. Diabetes Care 32: 1058-1062, 2009.
4. Brownlee M, Hirsch IB. Glycemic variability: a hemoglobin A1cindependent risk factor for diabetic complications. JAMA 295: 1707-1708, 2006.
5. Nalysnyk L, Hernandez-Medina M, Krishnarajah G. Glycaemic variability and complications in patients with diabetes mellitus: evidence from a systematic review of the literature. Diabetes Obes Metab 12: 288-298, 2010.
6. Ceriello A, Ihnat MA. 'Glycaemic variability': a new therapeutic challenge in diabetes and the critical care setting. Diabet Med 27: 862-867, 2010.
7. Engler B, Koehler C, Hoffmann C, et al. Relationship between HbA1c on target, risk of silent hypoglycemia and glycemic variability in patients with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 119: 59-61, 2011.
8. Mastrototaro JJ. The Minimed Continuous Glucose Monitoring System (CGMS). J Pediatr Endocr Metab 12: 751-758, 1998.
9. Sartore G, Chilelli NC, Burlina S, et al. The importance of HbA1c and glucose variability in patients with type 1 and type 2 diabetes: outcome of continuous glucose monitoring (CGM). Acta Diabetol 2012.
10. Schmitz O, Juhl CB, Lund S, et al. HbA1c does not reflect prandial plasma glucose excursions in type 2 diabetes. Diabetes Care 23: 1859-1860, 2000.
11. Kohnert KD, Augstein P, Heinke P, et al. Chronic hyperglycemia but not glucose variability determines HbA1c levels in wellcontrolled patients with type 2 diabetes. Diabetes Res Clin Pract 77: 420-426, 2007.
12. Derr R, Garrett E, Stacy GA, Saudek CD. Is HbA(1c) affected by glycemic instability? Diabetes Care 26: 2728-2733, 2003.
13. De Fronzo RA, Abdul-Ghani MA. Preservation of beta-cell function: the key to diabetes prevention. J Clin Endocrinol Metab 96: 2354-2366, 2011.
14. Vella A, Zinsmeister AR. Predicting diabetes using measures of beta-cell function. Diabetes 61: 562-563, 2012.
15. Ize-Ludlow D, Lightfoot YL, Parker M, et al. Progressive erosion of beta-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes. Diabetes 60: 2086-2091, 2011.
16. Gu Z, Du Y, Liu Y, et al. Effect of aging on islet beta-cell function and its mechanisms in Wistar rats. Age (Dordr) 2011.
17. Tschen SI, Dhawan S, Gurlo T, Bhushan A. Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes 58: 1312-1320, 2009.