Assessment of practice patterns of perioperative management of antiplatelet and anticoagulant therapy in interventional pain management

Pain Physician

Volumn 15, Issue 6, 2012, Pages

  Manchikanti, Laxmaiah ^a,b   Benyamin, Ramsin M ^c,d   Swicegood, John R ^e   Falco, Frank J E ^e,f   Datta, Sukdeb ^g,h   Pampati, Vidyasagar ^a,b   Fellows, Bert ^a,b   Hirsch, Joshua A ⁱ  

^a PAIN MANAGEMENT CENTER OF PADUCAH   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c MILLENNIUM PAIN CENTER   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e Advanced Interventional Pain and Diagnostics of Western Arkansas   (United States)

^f Mid Atlantic Spine and Pain Physicians   (United States)

^g TEMPLE UNIVERSITY HOSPITAL   (United States)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Anticoagulants; Antiplatelet therapy; Aspirin; Bleeding; Clopidogrel (Plavix); Complications; Hemostasis; Interventional pain management; Interventional techniques; Thromboembolic events; Warfarin (Coumadin)

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CILOSTAZOL; CLOPIDOGREL; DABIGATRAN; DABIGATRAN ETEXILATE; DIPYRIDAMOLE; NONSTEROID ANTIINFLAMMATORY AGENT; PERMOLE; RIVAROXABAN; TICLOPIDINE; TIROFIBAN; UNCLASSIFIED DRUG; WARFARIN;

ANALGESIA; ANTICOAGULANT THERAPY; BLEEDING; DISEASE SEVERITY; DRUG SAFETY; DRUG WITHDRAWAL; EPIDURAL HEMATOMA; HEALTH SURVEY; HUMAN; INTERNATIONAL NORMALIZED RATIO; MEDICAL PRACTICE; MEDICAL SOCIETY; MEDICAL SPECIALIST; ONLINE SYSTEM; PERIOPERATIVE PERIOD; REVIEW; THROMBOEMBOLISM; UNITED STATES;

ANTICOAGULANTS; HUMANS; PAIN MANAGEMENT; PERIOPERATIVE CARE; PHYSICIAN'S PRACTICE PATTERNS; PLATELET AGGREGATION INHIBITORS;

EID: 84869814776     PISSN: 15333159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (100)

1. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O'Donnell C, Kittner S, Lloyd-Jones D, Goff DC Jr, Hong Y, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M, Wolf P. Heart Disease and Stroke Statistics-2006 Update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006; 113:E85-E151.
2. Mendis S, Puska P, Norrving B (eds). Global Atlas on Cardiovascular Disease Prevention and Control. Word Health Organization, Geneva, 2011.
3. Price MJ, Berger PB, Teirstein PS, Tanguay JF, Angiolillo DJ, Spriggs D, Puri S, Robbins M, Garratt KN, Bertrand OF, Stillablower ME, Aragon JR, Kandzari DE, Stinis CT, Lee MS, Manoukian SV, Cannon CP, Schork NJ, Topol EJ; GRAVITAS Investigators. Standard-vs highdose clopidogrel based on platelet function testing after percutaneous coronary intervention: The GRAVITAS randomized trial. JAMA 2011; 305:1097-1105.
4. Ho PM, Peterson ED, Wang L, Magid DJ, Fihn SD, Larsen GC, Jesse RA, Rumsfeld JS. Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. JAMA 2008; 299:532-539. Erratum in: JAMA 2008; 299:2390.
5. Berger JS, Krantz MJ, Kittelson JM, Hiatt WR. Aspirin for the prevention of cardiovascular events in patients with peripheral artery disease: A meta-analysis of randomized trials. JAMA 2009; 301:1909-1919.
6. Manchikanti L, Boswell MV, Singh V, Benyamin RM, Fellows B, Abdi S, Buenaventura RM, Conn A, Datta S, Derby R, Falco FJE, Erhart S, Diwan S, Hayek SM, Helm S, Parr AT, Schultz DM, Smith HS, Wolfer LR, Hirsch JA. Comprehensive evidence-based guidelines for interventional techniques in the management of chronic spinal pain. Pain Physician 2009; 12:699-802.
7. Manchikanti L, Pampati V, Singh V, Boswell MV, Smith HS, Hirsch JA. Explosive growth of facet joint interventions in the Medicare population in the United States: A comparative evaluation of 1997, 2002, and 2006 data. BMC Health Serv Res 2010; 10:84.
8. Manchikanti L, Pampati V, Boswell MV, Smith HS, Hirsch JA. Analysis of the growth of epidural injections and costs in the Medicare population: A comparative evaluation of 1997, 2002, and 2006 data. Pain Physician 2010; 13:199-212.
9. Manchikanti L, Pampati V, Falco FJE, Hirsch JA. Growth of spinal interventional pain management techniques: Analysis of utilization trends and medicare expenditures 2000 to 2008. Spine (Phila Pa 1976) 2012 July 11 [Epub ahead of print].
10. Abbott ZI, Nair KV, Allen RR, Akuthota VR. Utilization characteristics of spinal interventions. Spine J 2012; 1:35-43.
11. Chou R, Huffman L. Guideline for the Evaluation and Management of Low Back Pain: Evidence Review. American Pain Society, Glenview, IL, 2009. www.ampainsoc.org/pub/pdf/LBPEvidRev.pdf
12. Manchikanti L, Datta S, Derby R, Wolfer LR, Benyamin RM, Hirsch JA. A critical review of the American Pain Society clinical practice guidelines for interventional techniques: Part 1. Diagnostic interventions. Pain Physician 2010; 13:E141-E174.
13. Manchikanti L, Datta S, Gupta S, Munglani R, Bryce DA, Ward SP, Benyamin RM, Sharma ML, Helm II S, Fellows B, Hirsch JA. A critical review of the American Pain Society clinical practice guidelines for interventional techniques: Part 2. Therapeutic interventions. Pain Physician 2010; 13:E215-E264.
14. Manchikanti L, Singh V, Boswell MV. Interventional pain management at crossroads: The perfect storm brewing for a new decade of challenges. Pain Physician 2010; 13:E111-E140.
15. Benyamin RM, Datta S, Falco FJE. A perfect storm in interventional pain management: Regulated, but unbalanced. Pain Physician 2010; 13:109-116.
16. Manchikanti L, Singh V, Caraway DL, Benyamin RM, Hirsch JA. Medicare physician payment systems: Impact of 2011 schedule on interventional pain management. Pain Physician 2011; 14:E5-E33.
17. Manchikanti L, Hirsch JA. Medicare physician payment rules for 2011: A primer for the neurointerventionalist. J Neurointervent Surg 2011; 3:399-402.
18. Manchikanti L, Parr AT, Singh V, Fellows B. Ambulatory surgery centers and interventional techniques: A look at long-term survival. Pain Physician 2011; 14:E177-E215.
19. Manchikanti L, Falco FJ, Benyamin RM, Helm S 2nd, Parr AT, Hirsch JA. The impact of comparative effectiveness research on interventional pain management: Evolution from Medicare Modernization Act to Patient Protection and Affordable Care Act and the Patient-Centered Outcomes Research Institute. Pain Physician 2011; 14:E249-E282.
20. Manchikanti L, Giordano J, Fellows B, Hirsch JA. Placebo and nocebo in interventional pain management: A friend or a foe-or simply foes? Pain Physician 2011; 14:E157-E175.
21. Birkenmaier C, Terzis A, Wegener B, Melcher C, Fottner A, Hausdorf J, Schmitt-Sody M, Jansson V. The gel box-a testing device for the characterization of cryo-and radiofrequency lesions employed in interventional pain therapy. Pain Physician 2010; 13:263-271.
22. Park CH, Lee SH, Jung JY. Dural sac cross-sectional area does not correlate with efficacy of percutaneous adhesiolysis in single level lumbar spinal stenosis. Pain Physician 2011; 14:377-382.
23. Manchikanti L, Malla Y, Wargo BW, Cash KA, McManus CD, Damron KS, Jackson SD, Pampati V, Fellows B. A prospective evaluation of bleeding risk of interventional techniques in chronic pain. Pain Physician 2011; 14:317-329.
24. Horlocker TT, Bajwa ZH, Ashraf Z, Khan S, Wilson JL, Sami N, Peeters-Asdourian C, Powers CA, Schroeder DR, Decker PA, Warfield CA. Risk assessment of hemorrhagic complications associated with nonsteroidal antiinflammatory medications in ambulatory pain clinic patients undergoing epidural steroid injection. Anesth Analg 2002; 95:1691-1697.
25. Vicenzi MN, Meislitzer T, Heitzinger B, Halaj M, Fleisher LA, Metzier H. Coronary artery stenting and non-cardiac surgery-a prospective outcome study. Br J Anaesth 2006; 96:686693.
26. Chassot PG, Marcucci C, Delabays A, Spahn DR. Perioperative antiplatelet therapy. Am Fam Physician 2010; 82:1484-1489.
27. Vilahur G, Choi BG, Zafar MU, Viles-Gonzalez JF, Vorchheimer DA, Fuster V, Badimon JJ. Normalization of platelet reactivity in clopidogrel-treated subjects. J Thromb Haemost 2007; 5:82-90.
28. Collet JP, Montalescot G, Blanchet B, Tanguy ML, Golmard JL, Choussat R, Beygui F, Payot L, Vignolles N, Metzger JP, Thomas D. Impact of prior use or recent withdrawal of oral antiplatelet agents on acute coronary syndrome. Circulation 2004; 110:23612367.
29. Murphy JT, Brenda GF. Thrombosis of sirolimus-eluting coronary stent in the postanesthesia care unit. Anesth Analg 2005; 101:971-973.
30. Sharma AK, Ajani AE, Hamwi SM, Maniar P, Lakhani SV, Waksman R, Lindsay J. Major noncardiac surgery following coronary stenting: When is it safe to operate? Catheter Cardiovasc Interv 2004; 63:141-145.
31. Biondi-Zoccai GG, Lotrionte M, Agostoni P, Abbate A, Fusaro M, Burzotta F, Testa L, Sheiban I, Sangiorgi G. A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronary artery disease. Eur Heart J 2006; 27:2667-2674.
32. Lordkipanidzé M, Diodati JG, Pharand C. Possibility of a rebound phenomenon following antiplatelet therapy withdrawal: A look at the clinical and pharmacological evidence. Pharmacol Ther 2009; 123:178-186.
33. Horlocker TT, Wedel DJ, Rowlingson JC, Enneking FK, Kopp SL, Benzon HT, Brown DL, Heit JA, Mulroy MF, Rosenquist RW, Tryba M, Yuan CS. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition). Reg Anesth Pain Med 2010; 35:64-101.
34. Gogarten W, Vandermeulen E, Van Aken H, Kozek S, Llau JV, Samama CM; European Scoeity of Anaesthesiology. Regional anaesthesia and antithrombotic agents: Recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol 2010; 27:999-1015.
35. Breivik H, Bang U, Jalonen J, Vigfússon G, Alahuhta S, Lagerkranser M. Nordic guidelines for neuraxial blocks in disturbed haemostasis from the Scandinavian Society of Anaesthesiology and Intensive Care Medicine. Acta Anaesthesiol Scand 2010; 54:16-41.
36. Llau JV, De Andrés J, Gomar C, Gómez-Luque A, Hidalgo F, Torres LM. Anticlotting drugs and regional anaesthetic and analgesic techniques: Comparative update of the safety recommendations. Eur J Anaesthesiol 2007; 24:387-398. Erratum in: Eur J Anaesthesiol 2007; 24:iv.
37. Vandermeulen E, Decoster J, Dewandre PY, Ickx BE, Vercauteren M, Verhamme P; Belgian Association for Regional Anesthesia. Central neural blockade in patients with a drug-induced alteration of coagulation. Third edition of the Belgian Association for Regional Anaesthesia (BARA) guidelines. Acta Anaesthesiol Belg 2011; 62:175-191.
38. Green L, Machin SJ. Managing anticoagulated patients during neuraxial anaesthesia. Br J Haematol 2010; 149:195-208.
39. Rosencher N, Bonnet MP, Sessler DI. Selected new antithrombotic agents and neuraxial anaesthesia for major orthopaedic surgery: Management strategies. Anaesthesia 2007; 62:1154-1160.
40. Vandermeulen E. Regional anaesthesia and anticoagulation. Best Pract Res Clin Anaesthesiol 2010; 24:121-131.
41. Breivik H, Norum HM. Regional analgesia--risks and benefits. Tidsskr Nor Laegeforen 2010; 130:392-397.
42. Horlocker TT. Regional anaesthesia in the patient receiving antithrombotic and antiplatelet therapy. Br J Anaesth 2011; 107:i96-i106.
43. Raj PP, Shah RV, Kaye AD, Denaro S, Hoover JM. Bleeding risk in interventional pain practice: Assessment, management, and review of the literature. Pain Physician 2004; 7:3-51.
44. Bugada D, Massimo A, Nicola Z, Antonio B, Battista B, Paolo G. Regional anesthesia and anticoagulant drugs: A survey of current Italian practice. Eur J Pain Suppl 2011; 5:335-343.
45. Iakovou I, Schmidt T, Bonizzoni E, Ge L, Sangiorgi GM, Stankovic G, Airoldi F, Chieffo A, Montorfano M, Carlino M, Michev I, Corvaja N, Briguori C, Gerckens U, Grube E, Colombo A. Incidence, predictors, and outcome of thrombosis after successful implantation of drug eluting stents. JAMA 2005; 293:2126-2130.
46. Spertus JA, Kettelkamp R, Vance C, Decker C, Jones PG, Rumsfeld JS, Messenger JC, Khanal S, Peterson ED, Bach RG, Krumholz HM, Cohen DJ. Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: Results from the PREMIER registry. Circulation 2006; 113:2803-2809.
47. Horlocker TT, Wedel DJ, Schroeder DR, Rose SH, Elliott BA, McGregor DG, Wong GY. Preoperative antiplatelet therapy does not increase the risk of spinal hematoma associated with regional anesthesia. Anesth Analg 1995; 80:303-309.
48. Horlocker TT, Wedel DJ, Offord KP. Does preoperative antiplatelet therapy increase the risk of hemorrhagic complications associated with regional anesthesia? Anesth Analg 1990; 70:631-634.
49. Maier C, Gleim M, Weiss T, Stachetzki U, Nicolas V, Zenz M. Severe bleeding following lumbar sympathetic blockade in two patients under medication with irreversible platelet aggregation inhibitors. Anesthesiology 2002; 97:740-743.
50. Benzon HT, Wong HY, Siddiqui T, Ondra S. Caution in performing epidural injections in patients on several antiplatelet drugs. Anesthesiology 1999; 91:1558-1559.
51. Williams KN, Jackowski A, Evans PJ. Epidural haematoma requiring surgical decompression following repeated cervical epidural steroid injections for chronic pain. Pain 1990; 42:197-199.
52. Weller RS, Gerancher JC, Crews JC, Wade KL. Extensive retroperitoneal hematoma without neurologic deficit in two patients who underwent lumbar plexus block and were later anticoagulated. Anesthesiology 2003; 98:581-585.
53. Borges G, Bonilha L, Maldaum MV, Menezes JR, Zanardi V. Acute cervical epidural hematoma: Case report. Arq Neuropsiquiatr 2000; 58:726-730.
54. Stoll A, Sanchez M. Epidural hematoma after epidural block: Implications for its use in pain management. Surg Neurol 2002; 57:235-240.
55. Heye N. Is there a link between acute spinal epidural hematoma and aspirin? Spine (Phila Pa 1976) 1995; 20:1931-1932.
56. Butterworth JF 4th, Rathmell JP. Standard care, standards for care, or standard of care? Anesthesiology 2010; 112:277-278.
57. Benzon HT, Avram MJ, Benzon HA, Kirby-Nolan M, Nader A. Factor VII levels and international normalized ratios in the early phase of warfarin therapy. Anesthesiology 2010; 112:298-304.
58. Szkup P, Stoneham G. Case report: Spontaneous spinal epidural haematoma during pregnancy: Case report and review of the literature. Br J Radiol 2004; 77:881-884.
59. Ruelle A, Datti R, Pisani R. Thoracic epidural hematoma after spinal manipulation therapy. J Spinal Disord 1999; 12:534-536.
60. Yagi S, Hida K, Iwasaki Y, Abe H, Akino M, Saito H. Cervical epidural hematoma caused by cervical twisting after epidural anesthesia: A case report. No Shinkei Geka 1998; 26:627-632.
61. Xu R, Bydon M, Gokaslan ZL Wolinsky JP, Witham TF, Bydon A. Epidural steroid injection resulting in epidural hematoma in a patient despite strict adherence to anticoagulation guidelines. J Neurosurg Spine 2009; 11:358-364.
62. Ain RJ, Vance MB. Epidural hematoma after epidural steroid injection in a patient withholding enoxaparin per guidelines. Anesthesiology 2005; 102:701-703.
63. Linn AJ, Desilva C, Peeters-Asdourian C. Thromboembolic stroke: A rare complication associated with peri-procedural management of an epidural steroid injection. Pain Physician 2009; 12:159-162.
64. Di Minno MN, Prisco D, Ruocco AL, Mastronardi P, Massa S, Di Minno G. Perioperative handling of patients on antiplatelet therapy with need for surgery. Intern Emerg Med 2009; 4:279-288.
65. Dunn AS, Turpie AG. Perioperative management of patients receiving oral anticoagulants: A systematic review. Arch Intern Med 2003; 163:901-908.
66. Abu Daya H, Younan L, Sharara AI. Endoscopy in the patient on antithrombotic therapy. Curr Opin Gastroenterol 2012; 28:432-441.
67. Yasaka M, Okada Y, Inoue T, Yoshikawa H, Saku M. Questionnaire survey to investigate correspondence of medical doctors and dentists in Japan for antithrombotic therapy at surgeries or biopsy. Brain Nerve 2007; 59:871-876.
68. Shuler JD, Paschal JF, Holland GN. Antiplatelet therapy and cataract surgery. J Cataract Refract Surg 1992; 18:567-571.
69. Stone DH, Goodney PP, Schanzer A, Nolan BW, Adams JE, Powell RJ, Walsh DB, Cronenwett JL; Vascular Study Group of New England. Clopidogrel is not associated with major bleeding complications during peripheral arterial surgery. J Vasc Surg 2011; 54:779-784.
70. Lawton MT, Porter RW, Heiserman EJ, Jacobowitz R, Sonntag VK, Dickman CA. Surgical management of spinal epidural haematoma: Relationship between surgical timing and neurological outcome. J Neurosurg 1995; 83: 1-7.
71. Groen RJ, Van Alphen HA. Operative treatment of spontaneous spinal epidural haematomas: A study of the factors determining postoperative outcome. Neurosurgery 1996; 39:494-508.
72. Meikle J, Bird S, Nightingale JJ, White N. Detection and management of epidural haematomas related to anaesthesia in the UK: A national survey of current practice. Br J Anaesth 2008; 101:400-404.
73. Chang FC, Lirng JF, Chen SS, Luo CB, Guo WY, Teng MM, Chang CY. Contrast enhancement patterns of acute spinal epidural hematomas: A report of two cases. AJNR Am J Neuroradiol 2003; 24:366-369.
74. Kaner T, Sasani M, Oktenoglu T, Cirak B, Ozer AF. Postoperative spinal epidural hematoma resulting in cauda equina syndrome: A case report and review of the literature. Cases J 2009; 2:8584.
75. Patriquin C, Crowther M. Treatment of warfarin-associated coagulopathy with vitamin K. Expert Rev Hematol 2011; 4:657-665.
76. Hanslik T, Prinseau J. The use of vitamin K in patients on anticoagulant therapy: A practical guide. Am J Cardiovasc Drugs 2004; 4:43-55.
77. Denas G, Marzot F, Offelli P, Stendardo A, Cucchini U, Russo R, Nante G, Iliceto S, Pengo V. Effectiveness and safety of a management protocol to correct over-anticoagulation with oral vitamin K: A retrospective study of 1,043 cases. J Thromb Thrombolysis 2009; 27:340-347.
78. Manchikanti L, Benyamin RM, Falco FJE, Caraway DL, Datta S, Hirsch JA. Guidelines warfare over interventional techniques: Is there a lack of discourse or straw man? Pain Physician 2012; 15:E1-E26.
79. Manchikanti L, Falco FJE, Boswell MV, Hirsch JA. Facts, fallacies, and politics of comparative effectiveness research: Part 1. Basic considerations. Pain Physician 2010; 13:E23-E54.
80. Manchikanti L, Falco FJE, Boswell MV, Hirsch JA. Facts, fallacies, and politics of comparative effectiveness research: Part 2. Implications for interventional pain management. Pain Physician 2010; 13:E55-E79.
81. Manchikanti L, Cash KA, Pampati V, Wargo BW, Malla Y. The effectiveness of fluoroscopic cervical interlaminar epidural injections in managing chronic cervical disc herniation and radiculitis: Preliminary results of a randomized, double-blind, controlled trial. Pain Physician 2010; 13:223-236.
82. Manchikanti L, Singh V, Falco FJE, Cash KA, Pampati V. Evaluation of the effectiveness of lumbar interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: A randomized, double-blind, controlled trial. Pain Physician 2010; 13:343-355.
83. Manchikanti L, Cash KA, McManus CD, Pampati V, Benyamin RM. Preliminary results of a randomized, double-blind, controlled trial of fluoroscopic lumbar interlaminar epidural injections in managing chronic lumbar discogenic pain without disc herniation or radiculitis. Pain Physician 2010; 13:E279-E292.
84. Manchikanti L, Cash KA, McManus CD, Pampati V, Benyamin RM. A preliminary report of a randomized double-blind, active controlled trial of fluoroscopic thoracic interlaminar epidural injections in managing chronic thoracic pain. Pain Physician 2010; 13:E357-E369.
85. Manchikanti L, Cash KA, McManus CD, Pampati V, Smith HS. One year results of a randomized, double-blind, active controlled trial of fluoroscopic caudal epidural injections with or without steroids in managing chronic discogenic low back pain without disc herniation or radiculitis. Pain Physician 2011; 14:25-36.
86. Manchikanti L, Singh V, Cash KA, Pampati V, Damron KS, Boswell MV. A randomized, controlled, double-blind trial of fluoroscopic caudal epidural injections in the treatment of lumbar disc herniation and radiculitis. Spine (Phila Pa 1976) 2011; 36:1897-1905.
87. Manchikanti L, Singh V, Cash KA, Pampati V, Datta S. Management of pain of post lumbar surgery syndrome: Oneyear results of a randomized, double double-blind, active controlled trial of fluoroscopic caudal epidural injections. Pain Physician 2010; 13:509-521.
88. Manchikanti L, Cash RA, McManus CD, Pampati V, Fellows B. Fluoroscopic caudal epidural injections with or without steroids in managing pain of lumbar spinal stenosis: One year results of randomized, double-blind, active-controlled trial. J Spinal Disord Tech 2012; 25:226-234.
89. Manchikanti L, Singh V, Falco FJE, Cash KA, Pampati V. Evaluation of lumbar facet joint nerve blocks in managing chronic low back pain: A randomized, doubleblind, controlled trial with a 2-year follow-up. Int J Med Sci 2010; 7:124-135.
90. Manchikanti L, Singh V, Falco FJE, Cash KA, Fellows B. Comparative outcomes of a 2-year follow-up of cervical medial branch blocks in management of chronic neck pain: A randomized, double-blind controlled trial. Pain Physician 2010; 13:437-450.
91. Manchikanti L, Singh V, Falco FJE, Cash KA, Pampati V, Fellows B. Comparative effectiveness of a one-year follow-up of thoracic medial branch blocks in man agement of chronic thoracic pain: A randomized, double-blind active controlled trial. Pain Physician 2010; 13:535-548.
92. Manchikanti L, Cash KA, Pampati V, Wargo BW, Malla Y. Cervical epidural injections in chronic discogenic neck pain without disc herniation or radiculitis: Preliminary results of a randomized, double-blind, controlled trial. Pain Physician 2010; 13:E265-E278.
93. Manchikanti L, Malla Y, Wargo BW, Fellows B. Preoperative fasting before interventional techniques: Is it necessary or evidence-based? Pain Physician 2011; 14:459-467.
94. Manchikanti L, Malla Y, Wargo BW, Fellows B. Infection control practices (safe injection and medication vial utilization) for interventional techniques: Are they based on relative risk management or evidence? Pain Physician 2011; 14:425-434.
95. Manchikanti L, Vallejo R, Manchikanti KN, Benyamin RM, Datta S, Christo PJ. Effectiveness of long-term opioid therapy for chronic non-cancer pain. Pain Physician 2011; 14:E133-E156.
96. Solanki DR, Koyyalagunta D, Shah RV, Silverman SM, Manchikanti L. Monitoring opioid adherence in chronic pain patients: Assessment of risk of substance misuse. Pain Physician 2011; 14:E119-E131.
97. Manchikanti L, Ailinani H, Koyyalagunta D, Datta S, Singh V, Eriator I, Sehgal N, Shah RV, Benyamin RM, Vallejo R, Fellows B, Christo PJ. A systematic review of randomized trials of long-term opioid management for chronic non-cancer pain. Pain Physician 2011; 14:91-121.
98. Christo PJ, Manchikanti L, Ruan X, Bottros M, Hansen H, Solanki D, Jordan AE, Colson J. Urine drug testing in chronic pain. Pain Physician 2011; 14:123-143.
99. Manchikanti L, Fellows B, Ailinani H, Pampati V. Therapeutic use, abuse, and nonmedical use of opioids: A ten-year perspective. Pain Physician 2010; 13:401-435.
100. Fricker RD, Schonlau M. Advantages and disadvantages of internet research surveys: Evidence from the literature. Fields Methods 2002; 14:347-367.