Effects of power frequency electromagnetic fields on melatonin and sleep in the rat

Emerging Health Threats Journal

Volumn 5, Issue 1, 2012, Pages

  Dyche, Jeff ^a   Anch, A Michael ^b   Fogler, Kethera A J ^a   Barnett, David W ^b   Thomas, Cecil ^c  

^a JAMES MADISON UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

^c Saint Louis University   (United States)

Author keywords

6 sulphatoxymelatonin; Electromagnetic fields; Sleep; Sprague dawley

Indexed keywords

6 HYDROXYMELATONIN O SULFATE; MELATONIN;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROMAGNETIC FIELD; MALE; NONHUMAN; RAT; REM SLEEP; SLEEP INDUCTION; SLEEP PATTERN; SLEEP STAGE; SLEEP TIME; URINALYSIS;

EID: 84869808616     PISSN: None     EISSN: 17528550     Source Type: Journal    
DOI: 10.3402/ehtj.v5i0.10904     Document Type: Article

References (64)

1. Charles LE, Loomis D, Shy CM, Newman B, Millikan R, Nylander-French LA, et al. Electromagnetic fields, polychlorinated biphenyls, and prostate cancer mortality in electric utility workers. Am J Epidemiol. 2003;157:683-91.
2. StevensRG. Biologically based epidemiological studies of electric power and cancer. Environ Health Perspect. 1993;101:93-100.
3. Wartenberg D. Residential EMF exposure and childhood leukemia: meta-analysis and population attributable risk. Bioelectromagnetics. 2001;Suppl 5:S86-104.
4. Watson JM, Parrish EA, Rinehart CA. Selective potentiation of gynecologic cancer cell growth in vitro by electromagnetic fields. Gynecol Oncol. 1998;71:64-7.
5. Koh EK, Ryu BK, Jeong DY, Bang IS, Nam MH, Chae KS. A 60-Hz sinusoidal magnetic field induces apoptosis of prostate cancer cells through reactive oxygen species. Int J Radiat Biol. 2008;84:945-55.
6. Tenorio BM, Jimenez GC, Morais RN, Peixoto CA, Albuquerque Nogueira R, Silva Junior VA. Testicular development evaluation in rats exposed to 60 Hz and 1 mT electromagnetic field. J Appl Toxicol. 2011;31:223-30.
7. Wartenberg D. EMFs: cutting through the controversy. Pub Health Rep. 1996;111:204-17.
8. Van Wijngaarden E, Savitz DA, Kleckner RC, Cai J, Loomis D. Exposure to electromagnetic fields and suicide among electric utility workers: a nested case-control study. Occup Environ Med. 2000;57:258-63.
9. Lai H. Spatial learning deficit in the rat after exposure to a 60 Hz magnetic field. Bioelectromagnetics. 1996;17:494-6.
10. Mostafa RM, Mostafa YM, Ennaceur A. Effects of exposure to extremely low-frequency magnetic field of 2 G intensity on memory and corticosterone level in rats. Physiol Behav. 2002;76:589-95.
11. Thomas JR, Schrot J, Liboff AR. Low intensity magnetic fields alter operant behavior in rats. Bioelectromagnetics. 1986;7: 349-57.
12. Sun H, Che Y, Liu X, Zhou D, Miao Y, Ma Y. Effects of prenatal exposure to a 50-Hz magnetic field on one-trial passive avoidance learning in 1-day-old chicks. Bioelectromagnetics. 2010;31:150-5.
13. Cook CM, Saucier DM, Thomas AW, Prato FS. Exposure to ELF magnetic and ELF-modulated radiofrequency fields: the time course of pshysiological and cognitive effects observed in recent studies. Bioelectromagnetics. 2006;27:613-27.
14. Graham C, Cohen, HD, Cook MR. Immunological and biochemical effects of 60-Hz electric and magneticfields in humans. MRI Project No. RA-338-C. Kansas City: Midwest Research Institute; 1990.
15. Akerstadt T, Arnetz B, Ficca G, Paulsson LE, Kallner A. A 50-Hz electromagnetic field impairs sleep. J Sleep Res. 1999;8:77-81.
16. El-Helaly M, Abu-Hashem E. Oxidative stress, melatonin level, and sleep insufficiency among electronic equipment repairers. Indian J Occup Environ Med. 2010;14:66-70.
17. Wilson BW, Stevens RG, Anderson LE. Neuroendocrine mediated effects of electromagnetic field exposure: possible role of the pineal gland. Life Sci. 1989;45:1319-32.
18. Wilson BW, Wright CW, Morris RE, Buschbom DP, Brown DP, Miller DL, et al. Evidence for an effect of ELF electromagnetic fields on human pineal gland function. J Pineal Res. 1990;9:113-26.
19. Davis S, Mirick DK, Chen C, Stanczyk FZ. Effects of 60-Hz magnetic field exposure on nocturnal 6-sulfatoxymelatonin, estrogens, luteinizing hormone, and follicle-stimulating hormone in healthy reproductive-age women: results of a crossover trial. Ann Epidemiol. 2006;16:622-31.
20. Henshaw DL, Reiter RJ. Do magnetic fields cause increased risk of childhood leukemia via melatonin disruption? Bioelectromagnetics. 2005;Suppl 7:S86-97.
21. Stevens RG. The melatonin hypothesis: electric power and breast cancer. Environ Health Perspect. 1996;104:135-40.
22. Lissoni P. Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms. Ann N Y Acad Sci. 2000;917:560-7.
23. Girgert R, Hanf V, Emons G, Gründker C. Signal transduction of the melatonin receptor MT1 is disrupted in breast cancer cells by electromagnetic fields. Bioelectromagnetics. 2010;31:237-45.
24. Qi W, Reiter RJ, Tan DX, Manchester LC, Calvo JR. Melatonin prevents delta-aminolevulinic acid-induced oxidative DNA damage in the presence of Fe2-. Mol Cell Biochem. 2001;218:87-92.
25. Reiter RJ, Tan DX, Kim SJ, Manchester LC, Qi W, Garcia JJ, et al. Augmentation of indices of oxidative damage in life-long melatonin-deficient rats. Mech Ageing Dev. 1999;110:157-73.
26. Graham C, Cook MR, Riffle DW. Nocturnal melatonin levels in human volunteers exposed to intermittent 60 Hz magnetic fields. Bioelectromagnetics. 1996;17:263-73.
27. Wilson BW. 60-Hz electric field effects on pineal melatonin rhythms. Bioelectromagnetics. 1986;7:239-42.
28. Reiter RJ. Pineal gland, cellular proliferation and neoplastic growth: an historical account. In: Gupta G, Attanasio A, Reiter RJ, editors. The pineal gland and cancer. London: Brain research promotion; 1988. p. 41-64.
29. Reuss S, Olcese J, Vollrath L, Skaley M, Meves M. Lack of effects of NMR strength magnetic fields on rat pineal melatonin synthesis. IRCS Med Sci. 1985;13:471.
30. Kato M, Honma K, Shigemitsu Shiga Y. Effects of exposure to a circularly polarized 50 Hz magnetic field on plasma and pineal melatonin levels in rats. Bioelectromagnetics. 1993;14:97-106.
31. Loscher W, Mevissen M, Lerchl A. Exposure of female rats to a 100-microT 50 Hz magnetic field does not induce consistent changes in nocturnal levels of melatonin. Radiat Res. 1998;150:557-67.
32. Yellon SM, Truong HN. Melatonin rhythm onset in the adult siberian hamster: influence of photoperiod but not 60 Hz magnetic field exposure on melatonin content in the pineal gland and in circulation. J Bio Rhythms. 1998;13:52-9.
33. Graham C, Cook MR. Human sleep in 60 Hz magnetic fields. Bioelectromagnetics. 1999;20:277-83.
34. Graham C, Cook MR, Gerkovich MM, Sastre A. Examination of the melatonin hypothesis in women exposed at night to EMF or bright light. Environ Health Perspect. 2001;109:501-7.
35. Gobba F, Bravo G, Scaringi M, Roccatto L. No association between occupational exposure to ELF magnetic field and urinary 6-sulfatoximelatonin in workers. Bioelectromagnetics. 2006;27:667-73.
36. Jentsch A, Lehmann M, Schon E, Thoss F, Zimmerman G. Weak magnetic fields change extinction of a conditioned reaction and daytime melatonin levels in the rat. Neurosci Lett. 1993;157:79-82.
37. Truong H, Yellon SM. Effects of various acute 60 Hz magnetic field exposures on the nocturnal melatonin rise in the Djungarian hamster. J Pineal Res. 1997;22:177-83.
38. Rechtscheffan A. Standardization of sleep architecture in the rat. Sleep. 1960;9:20-34.
39. Brown GM, Bar-Or A, Grossi D, Kashur S, Johansson SM, Yie SM. Urinary 6-sulphatoxymelatonin, an index of pineal function in the rat. J Pineal Res. 1991;10:141-7.
40. Jaffe RA. Chronic exposure to a 60-Hz electric field: effects on neuromuscular function in the rat. Bioelectromagnetics. 1980;2:227-39.
41. Klante G, Brinsscwitz T, Secci K, Wollnik F, Steinlechner S. Creatinine is an appropriate reference for urinary melatonin of laboratory animals and humans. J Pineal Res. 1997;23:191-7.
42. Semm P. Neurobiological investigations on the magnetic sensitivity of the pineal gland in rodents and pigeons. Comp Biochem Physiol. 1983;76A:683-9.
43. Kato M, Honma K, Shigemitsu Shiga Y. Horizontal or vertical 50 Hz, 1-microT magnetic fields have no effect on pineal gland or plasma melatonin concentration of albino rats. Neurosci Lett. 1994;168:205-8.
44. Welker HA, Semm P, Willig RP, Commentz JC, Wiltschko W, Vollrath L. Effects of artificial magnetic field on serotonin N-acetyltransferase and melatonin content of the rat pineal gland. Exp Brain Res. 1983;50:426-32.
45. Yellon SM. Acute 60 Hz magnetic field exposure effects on the melatonin rhythm in the pineal gland and circulation of the adult Djungarian hamster. J Pineal Res. 1994;16:136-44.
46. Reiter RJ. Static and extremely low frequency electromagnetic field exposure: reported effects on the circadian production of melatonin. J Cell Biochem. 1993;51:394-403.
47. Rosen LA, Barber I, Lyle DB. A 0.5 G, 60 Hz magnetic field suppresses melatonin production in pinealocytes. Bioelectromagnetics. 1998;19:123-7.
48. Graham C, Cook MR, Cohen HD, Riffle DW, Hoffman S, Gerkovich MM. Human exposure to 60-Hz magnetic fields: neurophysiological effects. Int J Psychophys. 1999;33:169-75.
49. Bakos J, Nagy N, Thuróczy G, Szabó LD. One week of exposure to 50 Hz, vertical magnetic field does not reduce urinary 6-sulphatoxymelatonin excretion of male wistar rats. Bioelectromagnetics. 2002;23:245-8.
50. Bakos J, Nagy N, Thuróczy G, Szabó LD. Urinary 6-sulphatoxymelatonin excretion is increased in rats after 24 hours of exposure to vertical 50 Hz, 100 microT magnetic field. Bioelectromagnetics. 1997;18:190-2.
51. Pfluger DH, Minder CE. Effects of exposure to 16.7 Hz magnetic fields onurinary 6-hydroxymelatonin sulfate excretion of Swiss railway workers. J Pineal Res. 1996;21:91-100.
52. Lerchl A, Zachmann A, Ali MA, Reiter RJ. The effects of pulsing magneticfields on pineal melatonin synthesis in a teleost fish (brook trout). Neurosci Lett. 1998;256:171-3.
53. Martinez-Soriano F, Gimenez-Gonzalez M, Armanazas E, Ruiz-Torner A. Pineal "synaptic ribbons"and serum melatonin levels in the rat following the pulse action of 52 Gs (50 Hz) magnetic fields: an evlutive analysis over 21 days. Acta Anat. 1992;143:289-93.
54. Blackman CF, Benane SG, Rainowitz JR, House DE, Joines WT. A Role for the magnetic field in the radiationinduced efflux of calcium ions from brain tissue in vitro. Bioelectromagnetics. 1985;6:327-37.
55. Bawin SM, Adey WR. Sensitivity of calcium binding in cerebral tissue to weak environmental electric fields oscillating at low frequency. PNAS. 1985;73:1999-2003.
56. Holmes SW, Sugden D. Effects of melatonin on sleep and neurochemistry in the rat. Br J Pharmacol. 1982;76:95-101.
57. Mendelson WB, Gillin JC, Dawson SD, Lewy AJ, Wyatt RJ. Effects of melatonin and propranolol on sleep of the rat. Brain Res. 1980;20:240-4.
58. Huber R, Deboer T, Schwierin B, Tobler I. Effect of melatonin on sleep and brain temperature in the Djungarian hamster and the rat. Physiol Behav. 1998;65:77-82.
59. Köylü H, Mollaoglu H, Ozguner F, Naziroglu M, Delibas N. Melatonin modulates 900 Mhz microwave-induced lipid peroxidation changes in rat brain. Toxicol Ind Health. 2006;22:211-6.
60. Koyu A, Ozguner F, Cesur G, Gokalp O, Mollaoglu H, Caliskan S, et al. No effects of 900 MHz and 1800 MHz electromagnetic field emitted from cellular phone on nocturnal serum melatonin levels in rats. Toxicol Ind Health. 2005;21: 27-31.
61. Cajochen C, Krauchi K, Wirz-Justice A. Role of melatonin in the regulation of human circadian rhythms and sleep. J Neuroendocrinol. 2003;15:432-7.
62. Reiter RJ. The melatonin rhythm: both a clock and a calendar. Cell Mol Life Sci. 1993;49:654-64.
63. Hong SC, Kurokawa Y, Kabuto M, Ohtsuka R. Chronic exposure to ELFmagnetic fields during night sleep with electric sheet: effects on diurnal melatonin rhythms in men. Bioelectromagnetics. 2001;22:138-43.
64. NRC (National Research Council). Health effects of residential electric and magnetic fields. Washington, DC: National Academy Press; 1997.