-
1
-
-
0035884395
-
The susceptibility of tumors to the antivascular drug combretastatin a4 phosphate correlates with vascular permeability
-
Beauregard, D.A., Hill, S.A., Chaplin, D.J. and Brindle, K.M. (2001) 'The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability', Cancer Res., Vol. 61, No. 18, pp.6811-6815.
-
(2001)
Cancer Res
, vol.61
, Issue.18
, pp. 6811-6815
-
-
Beauregard, D.A.1
Hill, S.A.2
Chaplin, D.J.3
Brindle, K.M.4
-
2
-
-
3543119624
-
Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced mri: A preclinical study of human melanoma xenografts
-
Benjaminsen, I.C., Graff, B.A., Brurberg, K.G. and Rofstad, E.K. (2004) 'Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced MRI: a preclinical study of human melanoma xenografts', Magn. Reson. Med., Vol. 52, No. 2, pp.269-276.
-
(2004)
Magn. Reson. Med
, vol.52
, Issue.2
, pp. 269-276
-
-
Benjaminsen, I.C.1
Graff, B.A.2
Brurberg, K.G.3
Rofstad, E.K.4
-
3
-
-
0042307678
-
Dynamic contrast-enhanced mri of vascular changes induced by the vegf-signalling inhibitor zd4190 in human tumour xenografts
-
Checkley, D., Tessier, J.J., Wedge, S.R., Dukes, M., Kendrew, J., Curry, B., Middleton, B. and Waterton, J.C. (2003) 'Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts', Magn. Reson. Imaging, Vol. 21, No. 5, pp.475-482.
-
(2003)
Magn. Reson. Imaging
, vol.21
, Issue.5
, pp. 475-482
-
-
Checkley, D.1
Tessier, J.J.2
Wedge, S.R.3
Dukes, M.4
Kendrew, J.5
Curry, B.6
Middleton, B.7
Waterton, J.C.8
-
4
-
-
1642494772
-
Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase i study in patients with advanced cancer
-
Cooney, M.M., Radivoyevitch, T., Dowlati, A, Overmoyer, B., Levitan, N., Robertson, K., Levine, S.L., DeCaro, K., Buchter, C., Taylor, A., Stamble, B.S. and Remick, S.C. (2004) 'Cardiovascular safety profile of combretastatin A4 phosphate in a single-dose phase I study in patients with advanced cancer', Clin. Cancer Res., Vol. 10, No. 1, pp.96-100.
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.1
, pp. 96-100
-
-
Cooney, M.M.1
Radivoyevitch, T.2
Dowlati, A.3
Overmoyer, B.4
Levitan, N.5
Robertson, K.6
Levine, S.L.7
DeCaro, K.8
Buchter, C.9
Taylor, A.10
Stamble, B.S.11
Remick, S.C.12
-
5
-
-
0030951899
-
Combretastatin a-4, an agent that displays potent and selective toxicity toward tumor vasculature
-
Dark, G.G., Hill, S.A., Prise, V.E., Tozer, G.M., Pettit, G.R. and Chaplin, D.J. (1997) 'Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature', Cancer Res., Vol. 57, No. 10, pp.1829-1834.
-
(1997)
Cancer Res
, vol.57
, Issue.10
, pp. 1829-1834
-
-
Dark, G.G.1
Hill, S.A.2
Prise, V.E.3
Tozer, G.M.4
Pettit, G.R.5
Chaplin, D.J.6
-
6
-
-
0036891441
-
Enhancement of vascular targeting by inhibitors of nitric oxide synthase
-
Davis, P.D., Tozer, G.M., Naylor, M.A., Thomson, P., Lewis, G. and Hill, S.A. (2002) 'Enhancement of vascular targeting by inhibitors of nitric oxide synthase', Int. J. Radiat. Oncol. Biol. Phys., Vol. 54, No. 5, pp.1532-1536.
-
(2002)
Int. J. Radiat. Oncol. Biol. Phys
, vol.54
, Issue.5
, pp. 1532-1536
-
-
Davis, P.D.1
Tozer, G.M.2
Naylor, M.A.3
Thomson, P.4
Lewis, G.5
Hill, S.A.6
-
7
-
-
0037096814
-
A phase i pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
-
Dowlati, A., Robertson, K., Cooney, M., Petros, W., Stratford, M., Jesberger, J., Rafie, N., Overmoyer, B., Makkar, V., Stambler, B., Taylor, A., Waas, J., Lewin, J., McCrae, K. and Remick, S. (2002) 'A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin A-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer', Cancer Res., Vol. 62, No. 12, pp.3408-3416.
-
(2002)
Cancer Res
, vol.62
, Issue.12
, pp. 3408-3416
-
-
Dowlati, A.1
Robertson, K.2
Cooney, M.3
Petros, W.4
Stratford, M.5
Jesberger, J.6
Rafie, N.7
Overmoyer, B.8
Makkar, V.9
Stambler, B.10
Taylor, A.11
Waas, J.12
Lewin, J.13
McCrae, K.14
Remick, S.15
-
8
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent?
-
Folkman, J. (1990) 'What is the evidence that tumors are angiogenesis dependent?', J. Natl. Cancer Inst., Vol. 82, No. 1, pp.4-6.
-
(1990)
J. Natl. Cancer Inst
, vol.82
, Issue.1
, pp. 4-6
-
-
Folkman, J.1
-
9
-
-
0042386691
-
Combretastatin a4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging
-
Galbraith, S.M., Maxwell, R.J., Lodge, M.A., Tozer, G.M., Wilson, J., Taylor, N.J., Stirling, J.J., Sena, L., Padhani, A.R. and Rustin, G.J. (2003) 'Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging', J. Clin. Oncol., Vol. 21, No. 15, pp.2831-2842.
-
(2003)
J. Clin. Oncol
, vol.21
, Issue.15
, pp. 2831-2842
-
-
Galbraith, S.M.1
Maxwell, R.J.2
Lodge, M.A.3
Tozer, G.M.4
Wilson, J.5
Taylor, N.J.6
Stirling, J.J.7
Sena, L.8
Padhani, A.R.9
Rustin, G.J.10
-
10
-
-
0141518578
-
Structural requirements for the interaction of combretastatins with tubulin: How important is the trimethoxy unit?
-
Gaukroger. K., Hadfield, J.A., Lawrence, N., Nolan, S. and McGown, A. (2003) 'Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?', Org. Biomol. Chem., Vol. 1, No. 17, pp.3033-3037.
-
(2003)
Org. Biomol. Chem
, vol.1
, Issue.17
, pp. 3033-3037
-
-
Gaukroger, K.1
Hadfield, J.A.2
Lawrence, N.3
Nolan, S.4
McGown, A.5
-
11
-
-
84869811366
-
-
US Patent 7,220784
-
Hadfield, J., McGown, A.T, Mayalarp, S., Land, E.J., Hamblett, I, Gaukroger, K., Lawrence, N.J., Hepworth, L.A. and Butler, J. (2007) Substituted stilbenes and their reactions, US Patent 7,220,784.
-
(2007)
Substituted Stilbenes and Their Reactions
-
-
Hadfield, J.1
McGown, A.T.2
Mayalarp, S.3
Land, E.J.4
Hamblett, I.5
Gaukroger, K.6
Lawrence, N.J.7
Hepworth, L.A.8
Butler, J.9
-
12
-
-
19544367790
-
Synthesis and evaluation of double bond substituted combretastatins
-
Hadfield, J.A., Gaukroger, K., Hirst, N., Weston, A.P., Lawrence, N.J. and McGown, A.T. (2005) 'Synthesis and evaluation of double bond substituted combretastatins', Eur. J. Med. Chem., Vol. 40, No. 6, pp.529-541.
-
(2005)
Eur. J. Med. Chem
, vol.40
, Issue.6
, pp. 529-541
-
-
Hadfield, J.A.1
Gaukroger, K.2
Hirst, N.3
Weston, A.P.4
Lawrence, N.J.5
McGown, A.T.6
-
13
-
-
0032532391
-
Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin a-4
-
Iyer, S., Chaplin, D.J., Rosenthal, D.S., Boulares, A.H., Li, L.Y. and Smulson, M.E. (1998) 'Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4', Cancer Res., Vol. 58, No. 20, pp.4510-4514.
-
(1998)
Cancer Res
, vol.58
, Issue.20
, pp. 4510-4514
-
-
Iyer, S.1
Chaplin, D.J.2
Rosenthal, D.S.3
Boulares, A.H.4
Li, L.Y.5
Smulson, M.E.6
-
14
-
-
33745215411
-
Qtl influencing baseline hematocrit in the c57bl/6j and dba/2j lineage: Age-related effects
-
Johannes, F., Blizard, D.A., Lionikas, A., Lang, D.H., Vandenbergh, D.J., Stout, J.T., Strauss, J.A., McClearn, G.E. and Vogler, G.P. (2006) 'QTL influencing baseline hematocrit in the C57BL/6J and DBA/2J lineage: age-related effects', Mamm. Genome, Vol. 17, No. 6, pp.689-699.
-
(2006)
Mamm. Genome
, vol.17
, Issue.6
, pp. 689-699
-
-
Johannes, F.1
Blizard, D.A.2
Lionikas, A.3
Lang, D.H.4
Vandenbergh, D.J.5
Stout, J.T.6
Strauss, J.A.7
McClearn, G.E.8
Vogler, G.P.9
-
15
-
-
0043287904
-
Synthesis and anticancer activity of fluorinated analogues of combretastatin a-4
-
Lawrence, N.L., Hepworth, L.A., Rennison, D., McGown, A.T. and Hadfield, J.A. (2003) 'Synthesis and anticancer activity of fluorinated analogues of combretastatin A-4', J. Fluor. Chem., Vol. 123, No. 1, pp.101-108.
-
(2003)
J. Fluor. Chem
, vol.123
, Issue.1
, pp. 101-108
-
-
Lawrence, N.L.1
Hepworth, L.A.2
Rennison, D.3
McGown, A.T.4
Hadfield, J.A.5
-
16
-
-
19944394201
-
The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: Issues and recommendations
-
Leach, M.O., Brindle, K.M., Evelhoch, J.L., Griffiths, J.R., Horsman, M.R., Jackson, A., Jayson, G.C., Judson, I.R., Knopp, M.V., Maxwell, R.J., McIntyre, D., Padhani, A.R., Price, P., Rathbone, R., Rustin, G.J., Tofts, P.S., Tozer, G.M., Vennart, W., Waterton, J.C., Williams, S.R. and Workman, P. (2005) 'The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations', Br. J. Cancer, Vol. 92, No. 9, pp.1599-1610.
-
(2005)
Br. J. Cancer
, vol.92
, Issue.9
, pp. 1599-1610
-
-
Leach, M.O.1
Brindle, K.M.2
Evelhoch, J.L.3
Griffiths, J.R.4
Horsman, M.R.5
Jackson, A.6
Jayson, G.C.7
Judson, I.R.8
Knopp, M.V.9
Maxwell, R.J.10
McIntyre, D.11
Padhani, A.R.12
Price, P.13
Rathbone, R.14
Rustin, G.J.15
Tofts, P.S.16
Tozer, G.M.17
Vennart, W.18
Waterton, J.C.19
Williams, S.R.20
Workman, P.21
more..
-
17
-
-
84869859506
-
Effects of an anti-Angiogenic and anti-Tumour antibody on tumour vasculature determined by dynamic contrast enhanced mri
-
presented at the 7-13 May 2005, Florida, USA
-
Linnik, I.V., Buckley, D.L. and Williams, S.R. (2005) 'Effects of an anti-Angiogenic and anti-Tumour antibody on tumour vasculature determined by dynamic contrast enhanced MRI', presented at the 13th Scientific Meeting International Society for Magnetic Resonance in Medicine, 7-13 May 2005, Florida, USA.
-
(2005)
13th Scientific Meeting International Society for Magnetic Resonance in Medicine
-
-
Linnik, I.V.1
Buckley, D.L.2
Williams, S.R.3
-
18
-
-
84869859505
-
Development of a murine isogenic graft model of endometriosis: Monitoring by dynamic contrast-enhanced mri
-
presented at the 6-12 May, 2000, Seattle, USA
-
Linnik, I.V., Williams, S.R., Davies, K.E., Murphy, P.S., Giorgio-Miller, A.D. and Buckley, D.L. (2006) 'Development of a murine isogenic graft model of endometriosis: monitoring by dynamic contrast-enhanced MRI', presented at the 14th Scientific Meeting International Society for Magnetic Resonance in Medicine, 6-12 May, 2000, Seattle, USA.
-
(2006)
14th Scientific Meeting International Society for Magnetic Resonance in Medicine
-
-
Linnik, I.V.1
Williams, S.R.2
Davies, K.E.3
Murphy, P.S.4
Giorgio-Miller, A.D.5
Buckley, D.L.6
-
19
-
-
0031814383
-
Measurement of perfusion rate in human melanoma xenografts by contrast-enhanced magnetic resonance imaging
-
Lyng, H., Dahle, G.A., Kaalhus, O., Skretting, A. and Rofstad, E.K. (1998) 'Measurement of perfusion rate in human melanoma xenografts by contrast-enhanced magnetic resonance imaging', Magn. Reson. Med., Vol. 40, No. 1, pp.89-98.
-
(1998)
Magn. Reson. Med
, vol.40
, Issue.1
, pp. 89-98
-
-
Lyng, H.1
Dahle, G.A.2
Kaalhus, O.3
Skretting, A.4
Rofstad, E.K.5
-
20
-
-
0036197311
-
Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced mri
-
Maxwell, R.J., Wilson, J., Prise, V.E., Vojnovic, B., Rustin, G.J., Lodge, M.A. and Tozer, G.M. (2002) 'Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI', NMR Biomed., Vol. 15, No. 2, pp.89-98.
-
(2002)
NMR Biomed
, vol.15
, Issue.2
, pp. 89-98
-
-
Maxwell, R.J.1
Wilson, J.2
Prise, V.E.3
Vojnovic, B.4
Rustin, G.J.5
Lodge, M.A.6
Tozer, G.M.7
-
21
-
-
0020956774
-
Graphical evaluation of blood-To-brain transfer constants from multiple-Time uptake data
-
Patlak, C.S., Blasberg, R.G. and Fenstermacher, J.D. (1983) 'Graphical evaluation of blood-To-brain transfer constants from multiple-Time uptake data', J. Cereb. Blood Flow Metab., Vol. 3, No. 1, pp.1-7.
-
(1983)
J. Cereb. Blood Flow Metab
, vol.3
, Issue.1
, pp. 1-7
-
-
Patlak, C.S.1
Blasberg, R.G.2
Fenstermacher, J.D.3
-
22
-
-
0029044610
-
Antineoplastic agents 322. Synthesis of combretastatin a-4 prodrugs
-
Pettit, G.R., Temple, C., Jr., Narayanan, V.L., Varma, R., Simpson, M.J. and Boyd, M.R., Rener, G.A. and Bansal, N. (1995) 'Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs', Anticancer Drug Des., Vol. 10, No. 4, pp.299-309.
-
(1995)
Anticancer Drug Des
, vol.10
, Issue.4
, pp. 299-309
-
-
Pettit, G.R.1
Temple Jr., C.2
Narayanan, V.L.3
Varma, R.4
Simpson, M.J.5
Boyd, M.R.6
Rener, G.A.7
Bansal, N.8
-
23
-
-
10744232021
-
Reduced capillary perfusion and permeability in human tumour xenografts treated with the vegf signalling inhibitor zd4190: An in vivo assessment using dynamic mr imaging and macromolecular contrast media
-
Pradel, C., Siauve, N., Bruneteau, G., Clement, O., de Bazelaire, C., Frouin, F., Wedge. S.R., Tessier, J.L., Robert, P.H., Frija, G. and Cuenod, C.A. (2003) 'Reduced capillary perfusion and permeability in human tumour xenografts treated with the VEGF signalling inhibitor ZD4190: an in vivo assessment using dynamic MR imaging and macromolecular contrast media', Magn. Reson. Imag., Vol. 21, No. 8, pp.845-851.
-
(2003)
Magn. Reson. Imag
, vol.21
, Issue.8
, pp. 845-851
-
-
Pradel, C.1
Siauve, N.2
Bruneteau, G.3
Clement, O.4
De Bazelaire, C.5
Frouin, F.6
Wedge, S.R.7
Tessier, J.L.8
Robert, P.H.9
Frija, G.10
Cuenod, C.A.11
-
24
-
-
0026011540
-
Measurement of the blood-brain barrier permeability and leakage space using dynamic mr imaging. 1. Fundamental concepts
-
Tofts, P.S. and Kermode, A.G. (1991) 'Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts', Magn. Reson. Med., Vol. 17, No. 7, pp.357-367.
-
(1991)
Magn. Reson. Med
, vol.17
, Issue.7
, pp. 357-367
-
-
Tofts, P.S.1
Kermode, A.G.2
-
25
-
-
0033119771
-
Combretastatin a-4 phosphate as a tumor vascular-Targeting agent: Early effects in tumors and normal tissues
-
Tozer, G.M., Prise, V.E., Wilson, J., Locke, R.J., Vojnovic. B., Stratford. M.R., Dennis, M.F. and Chaplin, D.J. (1999) 'Combretastatin A-4 phosphate as a tumor vascular-Targeting agent: early effects in tumors and normal tissues', Cancer Res., Vol. 59, No. 3, pp.1626-1634.
-
(1999)
Cancer Res
, vol.59
, Issue.3
, pp. 1626-1634
-
-
Tozer, G.M.1
Prise, V.E.2
Wilson, J.3
Locke, R.J.4
Vojnovic, B.5
Stratford, M.R.6
Dennis, M.F.7
Chaplin, D.J.8
-
26
-
-
0018842376
-
A new mouse tumor model system (rif-1) for comparison of end-point studies
-
Twentyman, P., Brown, J.M., Gray, J., Franko, A., Scoles, M. and Kallman, R. (1980) 'A new mouse tumor model system (RIF-1) for comparison of end-point studies', J. Natl. Cancer Inst., Vol. 64, No. 3, pp.595-604.
-
(1980)
J. Natl. Cancer Inst
, vol.64
, Issue.3
, pp. 595-604
-
-
Twentyman, P.1
Brown, J.M.2
Gray, J.3
Franko, A.4
Scoles, M.5
Kallman, R.6
-
27
-
-
1842607060
-
Combretastatin a4 phosphate
-
West, C.M. and Price, P. (2004) 'Combretastatin A4 phosphate', Anticancer Drugs, Vol. 15, pp.179-187.
-
(2004)
Anticancer Drugs
, vol.15
, pp. 179-187
-
-
West, C.M.1
Price, P.2
-
28
-
-
0028930050
-
The interaction with tubulin of a series of stilbenes based on combretastatin a-4
-
Woods, J.A., Hadfield, J.A., Pettit, G.R., Fox, B.W. and McGown, A.T. (1995) 'The interaction with tubulin of a series of stilbenes based on combretastatin A-4', Br. J. Cancer., Vol. 71, No. 3, pp.705-711.
-
(1995)
Br. J. Cancer
, vol.71
, Issue.3
, pp. 705-711
-
-
Woods, J.A.1
Hadfield, J.A.2
Pettit, G.R.3
Fox, B.W.4
McGown, A.T.5
-
29
-
-
3543138424
-
Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: Effects of transcytolemmal water exchange
-
Zhou, R., Pickup, S., Yankeelov, T.E., Springer, C.S., Jr. and Glickson, J.D. (2004) 'Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange', Magn. Reson. Med., Vol. 52, No. 4, pp.248-257.
-
(2004)
Magn. Reson. Med
, vol.52
, Issue.4
, pp. 248-257
-
-
Zhou, R.1
Pickup, S.2
Yankeelov, T.E.3
Springer Jr., C.S.4
Glickson, J.D.5
|