House dust mite allergy in Korea: The most important inhalant allergen in current and future

Allergy, Asthma and Immunology Research

Volumn 4, Issue 6, 2012, Pages 313-325

  Jeong, Kyoung Yong ^a   Park, Jung Won ^a   Hong, Chein Soo ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Allergen; Allergy; House dust mite; Korea

Indexed keywords

ADJUVANT; ANTIGEN; CHITIN; HOUSE DUST ALLERGEN; LIPID BINDING PROTEIN; PROTEINASE;

ATOPIC DERMATITIS; BINDING AFFINITY; CLIMATE; CULTURAL ANTHROPOLOGY; DERMATOPHAGOIDES; DERMATOPHAGOIDES FARINAE; DERMATOPHAGOIDES PTERONYSSINUS; DUST; ENVIRONMENTAL EXPOSURE; HEATING; HOME; HOUSE DUST ALLERGY; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INHALATION; KOREA; NONHUMAN; POPULATION DENSITY; RESPIRATORY TRACT ALLERGY; REVIEW; SENSITIZATION; TYROPHAGUS PUTRESCENTIAE;

EID: 84869773126     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2012.4.6.313     Document Type: Review

References (152)

1. Decker H. Asthma und milben. Munch Med Wochenschr 1928;75: 515-6.
2. Voorhorst R, Spieksma FT, Varekamp H, Leupen MJ, Lyklema AW. The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen. J Allergy 1967;39:325-339.
3. Miyamoto T, Oshima S, Ishizaki T, Sato SH. Allergenic identity between the common floor mite (Dermatophagoides farinae Hughes, 1961) and house dust as a causative antigen in bronchial asthma. J Allergy 1968;42:14-28.
4. Voorhorst R, Spieksma-Boezeman MI, Spieksma FT. Is a mite (Dermatophagoides sp.) the producer of the house-dust allergen? Allerg Asthma (Leipz) 1964;10:329-34.
5. Min TH, Hong CK, Ro BI, Chang CY. Allergen prick test reactivity in the patients with urticaria and atopic dermatitis. Korean J Dermatol 1987;25:587-98.
6. Kang SJ, Kim KH, Kim SH. A study on type I allergy to house dust mite in patients with atopic dermatitis. Korean J Dermatol 1991;29: 285-91.
7. Cho HJ, Choi HJ, Kim DK, Lee KH. Dermatophagoides farinae-specific IgE and IgG4 antibodies in atopic dermatitis patients. Korean J Dermatol 1998;36:16-22.
8. Yim YS, Park CW, Lee CH. A comparative study of atopy patch test using house dust mite antigens with skin prick test and specific serum IgE level in atopic dermatitis. Korean J Dermatol 2001;39: 1072-9.
9. Kim SS, Bang HD, Kim KH, Kim KJ. Evaluation of Pharmacia CAP system FEIA for house dust mites in patients with atopic dermatitis. Korean J Dermatol 2003;41:1455-62.
10. Shin JW, Jin SP, Lee JH, Cho S. Analysis of MAST-CLA results as a diagnostic tool in allergic skin diseases. Ann Dermatol 2010;22:35-40.
11. Ahu SD, Kim HJ. The allergen skin test and the effect of specific desensitising vaccination therapy in allergic rhinitis and bronchial asthma. Allergy 1983;3:159-67.
12. Kang SY, Choi BW, Moon HB, Min KU, Kim YY. The prevalence of immediate skin reactions in patients with respiratory allergies. Allergy 1984;4:49-56.
13. Cho HS, Lee KH, Choi YK, Cho DK, Kim NS. Result of allergen skin tests in type I hypersensitivity. Allergy 1985;5:14-22.
14. Rhee YG, Oh YI. Results of skin test, peripheral eosinophil count, total and specific IgE in allergic patients in Chonbuk area. Allergy 1985;5:147-55.
15. Jeong KY, Hong CS, Yong TS. Domestic arthropods and their allergens. Protein Pept Lett 2007;14:934-42.
16. Park HS, Choi GS, Cho JS, Kim YY. Epidemiology and current status of allergic rhinitis, asthma, and associated allergic diseases in Korea: ARIA Asia-Pacific workshop report. Asian Pac J Allergy Immunol 2009;27:167-71.
17. Lee SY, Kwon JW, Seo JH, Song YH, Kim BJ, Yu J, Park KS, Kim H, Kim EJ, Lee JS, Hong SJ. Prevalence of atopy and allergic diseases in Korean children: associations with a farming environment and rural lifestyle. Int Arch Allergy Immunol 2012;158:168-74.
18. Cho BK, Lee WK. House dust mites. Allergy 1981;1:138-44.
19. Chu JK, Song SB, Kim DK, Kim YK. Epidemiological studies on the acaroid mite. Korean J Parasitol 1967;5:69-75.
20. Cho BK, Houh W. The mite fauna of Korean house dust (I). Korean J Dermatol 1977;15:133-40.
21. Lee WK, Cho BK. An ecological study on the house dust mite. Korean J Dermatol 1984;22:286-94.
22. Ree HI, Jeon SH, Lee IY, Hong CS, Lee DK. Fauna and geographical distribution of house dust mites in Korea. Korean J Parasitol 1997;35:9-17.
23. Martínez J, Eraso E, Palacios R, Guisantes JA. Cross-reactions between Dermatophagoides pteronyssinus and Dermatophagoides farinae (Acari: Pyroglyphidae) related to the different growth phases of cultures. J Med Entomol 2000;37:35-9.
24. Munhbayarlah S, Park JW, Ko SH, Ree HI, Hong CS. Identification of Tyrophagus putrescentiae allergens and evaluation of cross-reactivity with Dermatophagoides pteronyssinus. Yonsei Med J 1998;39:109-15.
25. Park JW, Ko SH, Yong TS, Ree HI, Jeoung BJ, Hong CS. Cross-reactivity of Tyrophagus putrescentiae with Dermatophagoides farinae and Dermatophagoides pteronyssinus in urban areas. Ann Allergy Asthma Immunol 1999;83:533-9.
26. van Hage-Hamsten M, Johansson SG, Johansson E, Wiren A. Lack of allergenic cross-reactivity between storage mites and Dermatophagoides pteronyssinus. Clin Allergy 1987;17:23-31.
27. Lee JY. Tyrophagus putrescentiae: an important allergen in Daejeon. J Asthma Allergy Clin Immunol 2002;22:703-10.
28. Choi BS, Lee YJ, Baek JY, Kim KW, Sohn MH, Kim KE. Prevalence of sensitization to Tyrophagus putrescentiae in children with allergic diseases. Pediatr Allergy Respir Dis 2010;20:107-13.
29. Yong TS, Jeong KY. Review on ecology of house dust mites in Korea and suggestion of a standard survey method. Pediatr Allergy Respir Dis 2011;21:4-16.
30. Kim JH, Choi SY, Lee IY, Lee YW, Yong TS, Kim CW, Song YS, Park JW, Kim YS, Park JW, Hong CS. Seasonal variation of house dust mite and its influence on the inhabitant health. Korean J Asthma Allergy Clin Immunol 2006;26:27-34.
31. Dust mite allergens and asthma--a worldwide problem. J Allergy Clin Immunol 1989;83:416-27.
32. Hong CS. House dust mite and bronchial asthma - a worldwide problem. J Korean Med Assoc 1989;32:1078-83.
33. Hong CS. House dust mite and clinical allergy. Allergy 1991;11: 297-308.
34. Nam HS, Siebers R, Lee SH, Park JS, Kim YB, Choi YJ, Lee SH, Crane J. House dust mite allergens in domestic homes in Cheonan, Korea. Korean J Parasitol 2008;46:187-9.
35. Lee MK, Lee WY, Yong SJ, Shin KC, Lee SN, Lee SJ, Lee JH, Jung S, Jung YR, Kim SH. Sensitization rates to inhalant allergens in patients visiting a University Hospital in Gangwon region. Korean J Asthma Allergy Clin Immunol 2011;31:27-32.
36. Kim MK, Oh SW. Change of causative inhalant allergens in respiratory allergic patients in Chungbuk district. J Asthma Allergy Clin Immunol 1999;19:696-702.
37. Seo HR, Lee SM, Koo TH, Shin BC, Kim BK, Heo JH, Yang DK, Lee SK, Son CH. Sensitization rate to Tetranychus urticae and house dust mite in patients who visited the allergy clinic with allergic diseases in Busan area. Korean J Asthma Allergy Clin Immunol 2007; 27:263-7.
38. Choi JY, Sohn MH, Jang GC, Lee KE, Kim KE. Concentrations of dust mite in the dust of childhood bedclothing, cloth wrappers, and sewing dolls. Pediatr Allergy Respir Dis 2002;12:185-91.
39. Kim JL, Elfman L, Norbäck D. Respiratory symptoms, asthma and allergen levels in schools--comparison between Korea and Sweden. Indoor Air 2007;17:122-9.
40. Kim SK, Park HS, Oh SH, Hong CS. Distribution of house dust mites allergen in houses measured by RAST inhibition test. Korean J Intern Med 1988;35:65-75.
41. Chew GL, Higgins KM, Gold DR, Muilenberg ML, Burge HA. Monthly measurements of indoor allergens and the influence of housing type in a northeastern US city. Allergy 1999;54:1058-66.
42. Nahm DH, Park HS, Kang SS, Hong CS. Seasonal variation of skin reactivity and specific IgE antibody to house dust mite. Ann Allergy Asthma Immunol 1997;78:589-93.
43. Nahm DH, Park HS, Kim CW, Park JW, Hong CS. Seasonal variation of IgG subclass antibodies to house dust mite in sera from mite-sensitive asthmatic patients. Ann Allergy Asthma Immunol 1998; 80:411-5.
44. Sookrung N, Kamlanghan T, Indrawattana N, Tungtrongchitr A, Tantilipikorn P, Bunnag C, Pattanapanyasat K, Chaicumpa W. Quantification of Der f 1 in houses of patients allergic to house dust mite, Dermatophagoides farinae, using a locally produced detection reagents. Asian Pac J Allergy Immunol 2011;29:78-85.
45. Jeong KY, Lee IY, Yong TS, Lee JH, Kim EJ, Lee JS, Hong CS, Park JW. Sequence polymorphisms of Der f 1, Der p 1, Der f 2 and Der p 2 from Korean house dust mite isolates. Exp Appl Acarol. Forthcoming 2012.
46. Paik YH, Takaoka M, Matsuoka H, Ishii A. Mite fauna and mite antigen in house dust from houses in Seoul, Korea. Jpn J Sanit Zool 1992;43:29-35.
47. van Ree R. Indoor allergens: relevance of major allergen measurements and standardization. J Allergy Clin Immunol 2007;119:270-7.
48. Linneberg A. Are we getting enough allergens? Int Arch Allergy Immunol 2008;147:93-100.
49. Jeong KY, Yum HY, Lee IY, Ree HI, Hong CS, Kim DS, Yong TS. Molecular cloning and characterization of tropomyosin, a major allergen of Chironomus kiiensis, a dominant species of nonbiting midges in Korea. Clin Diagn Lab Immunol 2004;11:320-4.
50. Shin JW, Sue JH, Song TW, Kim KW, Kim ES, Sohn MH, Kim KE. Atopy and house dust mite sensitization as risk factors for asthma in children. Yonsei Med J 2005;46:629-34.
51. Kim KW, Kim EA, Kwon BC, Kim ES, Song TW, Sohn MH, Kim KE. Comparison of allergic indices in monosensitized and polysensitized patients with childhood asthma. J Korean Med Sci 2006;21: 1012-6.
52. Kang SS, Nahm DH, Kim CW, Park JW, Hong CS. The effect of the bedding cover made of a vapour-permeable water-proof fabric on allergic immune responses and clinical symptoms in house dust mite-sensitive asthmatics. Korean J Allergy 1996;16:26-37.
53. Kim C, Hong C, Choi S, Kim D. Simple application of allergen-impermeable bed covers for adult patients with allergic rhinitis in Korea. J Allergy Clin Immunol 2005;115:S268.
54. Nurmatov U, van Schayck CP, Hurwitz B, Sheikh A. House dust mite avoidance measures for perennial allergic rhinitis: an updated Cochrane systematic review. Allergy 2012;67:158-65.
55. Liu Z, Bai Y, Ji K, Liu X, Cai C, Yu H, Li M, Bao Y, Lian Y, Gao B. Detection of Dermatophagoides farinae in the dust of air conditioning filters. Int Arch Allergy Immunol 2007;144:85-90.
56. Agrawal SR, Kim HJ, Lee YW, Sohn JH, Lee JH, Kim YJ, Lee SH, Hong CS, Park JW. Effect of an air cleaner with electrostatic filter on the removal of airborne house dust mite allergens. Yonsei Med J 2010;51:918-23.
57. Park JW, Kim CW, Kang DB, Lee IY, Choi SY, Yong TS, Shin DC, Kim KE, Hong CS. Low-flow, long-term air sampling under normal domestic activity to measure house dust mite and cockroach allergens. J Investig Allergol Clin Immunol 2002;12:293-8.
58. Choi SY, Lee IY, Sohn JH, Lee YW, Shin YS, Yong TS, Hong CS, Park JW. Optimal conditions for the removal of house dust mite, dog dander, and pollen allergens using mechanical laundry. Ann Allergy Asthma Immunol 2008;100:583-8.
59. Baldo BA, Ford SA, Tovey ER. Toward a definition of the 'complete' spectrum and rank order of importance of the allergens from house dust mite: Dermatophagoides pteronyssinus. Adv Biosci 1989;74:13-31.
60. Hong CS, Lee MK, Oh SH. Identification of major allergens from the house dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssinus, by electroblotting. Yonsei Med J 1991;32:24-32.
61. Arlian LG, Bernstein IL, Geis DP, Vyszenski-Moher DL, Gallagher JS, Martin B. Investigations of culture medium-free house dust mites. III. Antigens and allergens of body and fecal extract of Dermatophagoides farinae. J Allergy Clin Immunol 1987;79:457-66.
62. Gregory LG, Lloyd CM. Orchestrating house dust mite-associated allergy in the lung. Trends Immunol 2011;32:402-11.
63. Radauer C, Bublin M, Wagner S, Mari A, Breiteneder H. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J Allergy Clin Immunol 2008; 121:847-52.e7.
64. Herbert CA, King CM, Ring PC, Holgate ST, Stewart GA, Thompson PJ, Robinson C. Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1. Am J Respir Cell Mol Biol 1995;12:369-78.
65. Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MB, Robinson C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999;104:123-33.
66. Wan H, Winton HL, Soeller C, Taylor GW, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA, Garrod DR, Robinson C. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clin Exp Allergy 2001;31:279-94.
67. Shakib F, Schulz O, Sewell H. A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity. Immunol Today 1998; 19:313-6.
68. Takahashi K, Aoki T, Kohmoto S, Nishimura H, Kodera Y, Matsushima A, Inada Y. Activation of kallikrein-kinin system in human plasma with purified serine protease from Dermatophagoides farinae. Int Arch Allergy Appl Immunol 1990;91:80-5.
69. Maruo K, Akaike T, Ono T, Okamoto T, Maeda H. Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease. J Allergy Clin Immunol 1997;100:253-60.
70. Lee SE, Jeong SK, Lee SH. Protease and protease-activated receptor-2 signaling in the pathogenesis of atopic dermatitis. Yonsei Med J 2010;51:808-22.
71. Adam E, Hansen KK, Astudillo Fernandez O, Coulon L, Bex F, Duhant X, Jaumotte E, Hollenberg MD, Jacquet A. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. J Biol Chem 2006; 281:6910-23.
72. Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008;9:310-8.
73. Smith PK, Harper JI. Serine proteases, their inhibitors and allergy. Allergy 2006;61:1441-7.
74. Cunningham PT, Elliot CE, Lenzo JC, Jarnicki AG, Larcombe AN, Zosky GR, Holt PG, Thomas WR. Sensitizing and Th2 adjuvant activity of cysteine protease allergens. Int Arch Allergy Immunol 2012; 158:347-58.
75. Jeong KY, Kim C, Yong TS. Enzymatic activities of allergen extracts from three species of dust mites and cockroaches commonly found in Korean home. Korean J Parasitol 2010;48:151-5.
76. Thomas WR, Hales BJ, Smith WA. Structural biology of allergens. Curr Allergy Asthma Rep 2005;5:388-93.
77. Thomas WR, Hales BJ, Smith WA. House dust mite allergens in asthma and allergy. Trends Mol Med 2010;16:321-8.
78. Park JW, Nahm DH, Hong CS. Determination of specific IgE to two major allergens (Der f I and Der f II) of house dust mite (D. farinae) in Korean adult respiratory allergy patients. Allergy 1993;13:476-86.
79. Hong CS, Park JW, Nahm DH. Measurement of IgE and IgG subclass antibodies to whole body antigen and two major allergens (Der fI & Der fII) of Dermatophagoides farinae in normal subjects and asthmatics. Yonsei Med J 1994;35:453-63.
80. Nahm DH, Park JW, Hong CS, Lee SY, Lee KY. Specific IgE antibodies to D. farinae whole body extract, Der f I and Der f II in child age groups. Pediatr Allergy Respir Dis 1995;5:117-24.
81. Park GM, Lee SM, Lee IY, Ree HI, Kim KS, Hong CS, Yong TS. Localization of a major allergen, Der p 2, in the gut and faecal pellets of Dermatophagoides pteronyssinus. Clin Exp Allergy 2000;30:1293-7.
82. Jeong KY, Lee IY, Ree HI, Hong CS, Yong TS. Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae. Allergy 2002;57:729-31.
83. Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009;457:585-8.
84. Osterlund C, Grönlund H, Polovic N, Sundström S, Gafvelin G, Bucht A. The non-proteolytic house dust mite allergen Der p 2 induce NF-κB and MAPK dependent activation of bronchial epithelial cells. Clin Exp Allergy 2009;39:1199-208.
85. Park SY, Cho JH, Oh DY, Park JW, Ahn MJ, Han JS, Oh JW. House dust mite allergen Der f 2-induced phospholipase D1 activation is critical for the production of interleukin-13 through activating transcription factor-2 activation in human bronchial epithelial cells. J Biol Chem 2009;284:20099-110.
86. Piboonpocanun S, Malainual N, Jirapongsananuruk O, Vichyanond P, Thomas WR. Genetic polymorphisms of major house dust mite allergens. Clin Exp Allergy 2006;36:510-6.
87. Jeong KY, Jin HS, Oh SH, Hong CS, Lee IY, Ree HI, Yong TS. Monoclonal antibodies to recombinant Der f 2 and development of a two-site ELISA sensitive to major Der f 2 isoallergen in Korea. Allergy 2002;57:29-34.
88. Park JW, Kim KS, Jin HS, Kim CW, Kang DB, Choi SY, Yong TS, Oh SH, Hong CS. Der p 2 isoallergens have different allergenicity, and quantification with 2-site ELISA using monoclonal antibodies is influenced by the isoallergens. Clin Exp Allergy 2002;32:1042-7.
89. Jin HS, Yong TS, Park JW, Hong CS, Oh SH. Immune reactivity of recombinant group 2 allergens of house dust mite, Dermatophagoides pteronyssinus, and Dermatophagoides farinae. J Investig Allergol Clin Immunol 2003;13:36-42.
90. Russano AM, Agea E, Casciari C, de Benedictis FM, Spinozzi F. Complementary roles for lipid and protein allergens in triggering innate and adaptive immune systems. Allergy 2008;63:1428-37.
91. Brewer JM, Tetley L, Richmond J, Liew FY, Alexander J. Lipid vesicle size determines the Th1 or Th2 response to entrapped antigen. J Immunol 1998;161:4000-7.
92. Jeong KY, Kim WK, Lee JS, Lee J, Lee IY, Kim KE, Park JW, Hong CS, Ree HI, Yong TS. Immunoglobulin E reactivity of recombinant allergen Tyr p 13 from Tyrophagus putrescentiae homologous to fatty acid binding protein. Clin Diagn Lab Immunol 2005;12:581-5.
93. Chan SL, Ong ST, Ong SY, Chew FT, Mok YK. Nuclear magnetic resonance structure-based epitope mapping and modulation of dust mite group 13 allergen as a hypoallergen. J Immunol 2006; 176:4852-60.
94. Epton MJ, Dilworth RJ, Smith W, Hart BJ, Thomas WR. High-molecular-weight allergens of the house dust mite: an apolipophorin-like cDNA has sequence identity with the major M-177 allergen and the IgE-binding peptide fragments Mag1 and Mag3. Int Arch Allergy Immunol 1999;120:185-91.
95. Fujikawa A, Ishimaru N, Seto A, Yamada H, Aki T, Shigeta S, Wada T, Jyo T, Murooka Y, Oka S, Ono K. Cloning and characterization of a new allergen, Mag 3, from the house dust mite, Dermatophagoides farinae: cross-reactivity with high-molecular-weight allergen. Mol Immunol 1996;33:311-9.
96. Fujikawa A, Uchida K, Yanagidani A, Kawamoto S, Aki T, Shigeta S, Wada T, Suzuki O, Jyo T, Ono K. Altered antigenicity of M-177, a 177-kDa allergen from the house dust mite Dermatophagoides farinae, in stored extract. Clin Exp Allergy 1998;28:1549-58.
97. Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM. Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol 2011;187:2261-7.
98. Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004;304:1678-82.
99. Shuhui L, Mok YK, Wong WS. Role of mammalian chitinases in asthma. Int Arch Allergy Immunol 2009;149:369-77.
100. McCall C, Hunter S, Stedman K, Weber E, Hillier A, Bozic C, Rivoire B, Olivry T. Characterization and cloning of a major high molecular weight house dust mite allergen (Der f 15) for dogs. Vet Immunol Immunopathol 2001;78:231-47.
101. Weber E, Hunter S, Stedman K, Dreitz S, Olivry T, Hillier A, McCall C. Identification, characterization, and cloning of a complementary DNA encoding a 60-kd house dust mite allergen (Der f 18) for human beings and dogs. J Allergy Clin Immunol 2003;112:79-86.
102. O'Neil SE, Heinrich TK, Hales BJ, Hazell LA, Holt DC, Fischer K, Thomas WR. The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pteronyssinus. Clin Exp Allergy 2006;36:831-9.
103. Liaw SH, Chen HZ, Liu GG, Chua KY. Acid-induced polymerization of the group 5 mite allergen from Dermatophagoides pteronyssinus. Biochem Biophys Res Commun 2001;285:308-12.
104. Naik MT, Chang CF, Kuo IC, Kung CC, Yi FC, Chua KY, Huang TH. Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: an NMR study on Blomia tropicalis major allergen. Structure 2008;16:125-36.
105. Gao YF, Wang de Y, Ong TC, Tay SL, Yap KH, Chew FT. Identification and characterization of a novel allergen from Blomia tropicalis: Blo t 21. J Allergy Clin Immunol 2007;120:105-12.
106. Khemili S, Kwasigroch JM, Hamadouche T, Gilis D. Modelling and bioinformatics analysis of the dimeric structure of house dust mite allergens from families 5 and 21: Der f 5 could dimerize as Der p 5. J Biomol Struct Dyn 2012;29:663-75.
107. Puerta L, Caraballo L, Fernández-Caldas E, Avjioglu A, Marsh DG, Lockey RF, Dao ML. Nucleotide sequence analysis of a complementary DNA coding for a Blomia tropicalis allergen. J Allergy Clin Immunol 1996;98:932-7.
108. Yi FC, Chen JY, Chee KK, Chua KY, Lee BW. Dust mite infestation of flour samples. Allergy 2009;64:1788-9.
109. Jeong KY, Hong CS, Yong TS. Allergenic tropomyosins and their cross-reactivities. Protein Pept Lett 2006;13:835-45.
110. Jeong KY, Lee H, Lee JS, Lee J, Lee IY, Ree HI, Hong CS, Yong TS. Molecular cloning and the allergenic characterization of tropomyosin from Tyrophagus putrescentiae. Protein Pept Lett 2007;14:431-6.
111. Rossi RE, Monasterolo G, Incorvaia C, Moingeon P, Frati F, Passalacqua G, Rossi L, Canonica GW. Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy. Clin Mol Allergy 2010;8:4.
112. Tsai LC, Chao PL, Shen HD, Tang RB, Chang TC, Chang ZN, Hung MW, Lee BL, Chua KY. Isolation and characterization of a novel 98-kd Dermatophagoides farinae mite allergen. J Allergy Clin Immunol 1998;102:295-303.
113. Tsai LC, Peng HJ, Lee CS, Chao PL, Tang RB, Tsai JJ, Shen HD, Hung MW, Han SH. Molecular cloning and characterization of full-length cDNAs encoding a novel high-molecular-weight Dermatophagoides pteronyssinus mite allergen, Der p 11. Allergy 2005;60:927-37.
114. Ramos JD, Cheong N, Lee BW, Chua KY. cDNA cloning and expression of Blo t 11, the Blomia tropicalis allergen homologous to paramyosin. Int Arch Allergy Immunol 2001;126:286-93.
115. Kojima S. Overview: from the horse experimentation by Prof. Akira Fujinami to paramyosin. Parasitol Int 2004;53:151-62.
116. Ramos JD, Teo AS, Ou KL, Tsai LC, Lee BW, Cheong N, Chua KY. Comparative allergenicity studies of native and recombinant Blomia tropicalis Paramyosin (Blo t 11). Allergy 2003;58:412-9.
117. Jeong KY, Kim CR, Un S, Yi MH, Lee IY, Park JW, Hong CS, Yong TS. Allergenicity of recombinant troponin C from Tyrophagus putrescentiae. Int Arch Allergy Immunol 2010;151:207-13.
118. Lake FR, Ward LD, Simpson RJ, Thompson PJ, Stewart GA. House dust mite-derived amylase: allergenicity and physicochemical characterization. J Allergy Clin Immunol 1991;87:1035-42.
119. Mills KL, Hart BJ, Lynch NR, Thomas WR, Smith W. Molecular characterization of the group 4 house dust mite allergen from Dermatophagoides pteronyssinus and its amylase homologue from Euroglyphus maynei. Int Arch Allergy Immunol 1999;120:100-7.
120. Sánchez-Monge R, García-Casado G, Barber D, Salcedo G. Interaction of allergens from house-dust mite and from cereal flours: Dermatophagoides pteronyssinus α-amylase (Der p 4) and wheat and rye α-amylase inhibitors. Allergy 1996;51:176-80.
121. Bowman CE, Lessiter MJ. Amylase and esterase polymorphisms in economically important stored product mites (Acari: Astigmata). Comp Biochem Physiol B 1985;81:353-60.
122. Batard T, Hrabina A, Bi XZ, Chabre H, Lemoine P, Couret MN, Faccenda D, Villet B, Harzic P, André F, Goh SY, André C, Chew FT, Moingeon P. Production and proteomic characterization of pharmaceutical-grade Dermatophagoides pteronyssinus and Dermatophagoides farinae extracts for allergy vaccines. Int Arch Allergy Immunol 2006;140:295-305.
123. Shen HD, Lin WL, Tsai LC, Tam MF, Chua KY, Chen HL, Hsieh KH, Li CS, Thomas WR. Characterization of the allergen Der f 7 from house dust mite extracts by species-specific and crossreactive monoclonal antibodies. Clin Exp Allergy 1997;27:824-32.
124. Shen HD, Chua KY, Lin WL, Hsieh KH, Thomas WR. Characterization of the house dust mite allergen Der p 7 by monoclonal antibodies. Clin Exp Allergy 1995;25:416-22.
125. Shen HD, Chua KY, Lin WL, Hsieh KH, Thomas WR. Molecular cloning and immunological characterization of the house dust mite allergen Der f 7. Clin Exp Allergy 1995;25:1000-6.
126. Shen HD, Chua KY, Lin WL, Chen HL, Hsieh KH, Thomas WR. IgE and monoclonal antibody binding by the mite allergen Der p 7. Clin Exp Allergy 1996;26:308-15.
127. Eriksson TL, Rasool O, Huecas S, Whitley P, Crameri R, Appenzeller U, Gafvelin G, van Hage-Hamsten M. Cloning of three new allergens from the dust mite Lepidoglyphus destructor using phage surface display technology. Eur J Biochem 2001;268:287-94.
128. Armstrong RN. Glutathione S-transferases: structure and mechanism of an archetypical detoxication enzyme. Adv Enzymol Relat Areas Mol Biol 1994;69:1-44.
129. Huang CH, Liew LM, Mah KW, Kuo IC, Lee BW, Chua KY. Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase. Clin Exp Allergy 2006;36:369-76.
130. Jeong KY, Jeong KJ, Yi MH, Lee H, Hong CS, Yong TS. Allergenicity of sigma and delta class glutathione S-transferases from the German cockroach. Int Arch Allergy Immunol 2009;148:59-64.
131. Kawamoto S, Aki T, Yamashita M, Tategaki A, Fujimura T, Tsuboi S, Katsutani T, Suzuki O, Shigeta S, Murooka Y, Ono K. Toward elucidating the full spectrum of mite allergens--state of the art. J Biosci Bioeng 2002;94:285-98.
132. Hales BJ, Martin AC, Pearce LJ, Laing IA, Hayden CM, Goldblatt J, Le Souëf PN, Thomas WR. IgE and IgG anti-house dust mite specificities in allergic disease. J Allergy Clin Immunol 2006;118:361-7.
133. Yu CJ, Lin YF, Chiang BL, Chow LP. Proteomics and immunological analysis of a novel shrimp allergen, Pen m 2. J Immunol 2003; 170:445-53.
134. Noss I, Wouters IM, Bezemer G, Metwali N, Sander I, Raulf-Heimsoth M, Heederik DJ, Thorne PS, Doekes G. β-(1,3)-Glucan exposure assessment by passive airborne dust sampling and new sensitive immunoassays. Appl Environ Microbiol 2010;76:1158-67.
135. Douwes J, Zuidhof A, Doekes G, Van der Zee SC, Wouters I, Boezen MH, Brunekreef B. (1→3)-β-D-glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med 2000;162:1348-54.
136. Rylander R. Organic dust induced pulmonary disease - the role of mould derived β-glucan. Ann Agric Environ Med 2010;17:9-13.
137. Mathaba LT, Pope CH, Lenzo J, Hartofillis M, Peake H, Moritz RL, Simpson RJ, Bubert A, Thompson PJ, Stewart GA. Isolation and characterisation of a 13.8-kDa bacteriolytic enzyme from house dust mite extracts: homology with prokaryotic proteins suggests that the enzyme could be bacterially derived. FEMS Immunol Med Microbiol 2002;33:77-88.
138. Aki T, Fujikawa A, Wada T, Jyo T, Shigeta S, Murooka Y, Oka S, Ono K. Cloning and expression of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae: homology with human heat shock cognate proteins in the heat shock protein 70 family. J Biochem 1994;115:435-40.
139. Saarne T, Kaiser L, Rasool O, Huecas S, van Hage-Hamsten M, Gafvelin G. Cloning and characterisation of two IgE-binding proteins, homologous to tropomyosin and α-tubulin, from the mite Lepidoglyphus destructor. Int Arch Allergy Immunol 2003;130:258-65.
140. Jeong KY, Lee H, Lee JS, Lee J, Lee IY, Ree HI, Hong CS, Park JW, Yong TS. Immunoglobulin E binding reactivity of a recombinant allergen homologous to α-tubulin from Tyrophagus putrescentiae. Clin Diagn Lab Immunol 2005;12:1451-4.
141. Aki T, Ono K, Paik SY, Wada T, Jyo T, Shigeta S, Murooka Y, Oka S. Cloning and characterization of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae. Int Arch Allergy Immunol 1994;103:349-56.
142. Ansotegui IJ, Härfast B, Jeddi-Tehrani M, Johansson E, Johansson SG, van Hage-Hamsten M, Wigzell H. Identification of a new major allergen of 39 kilodaltons of the storage mite Lepidoglyphus destructor. Immunol Lett 1991;27:127-30.
143. Stewart GA, Turner KJ. Physicochemical and immunochemical characterization of the high molecular weight allergens from Dermatophagoides pteronysisinus with particular reference to the tridacnin, Con-A and S107 reactive components. Aust J Exp Biol Med Sci 1980;58:275-88.
144. Olsson S, Harfast B, Johansson SG, van Hage-Hamsten M. Detection of at least one high-molecular-mass, IgE-binding component of the dust mite Lepidoglyphus destructor. Allergy 1994;49:620-5.
145. Park JW, Hong CS, Ko SH, Kim CW. IL-5 and IL-10 production of peripheral blood mononuclear cells by stimulation of D. farinae antigen in atopic asthmatics. J Asthma Allergy Clin Immunol 1999; 19:557-65.
146. Lee JS, Kim IS, Ryu JS, Yun CY. House dust mite, Dermatophagoides pteronyssinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells. Cytokine 2008;42:365-71.
147. Park JW, Park SW, Koe SW, Kim CW, Ree HI, Oh SH, Hong CS. Allergic immune responses to the fractionated antigen of Dermatophagoides pteronyssinus. Korean J Allergy 1997;17:151-64.
148. Kwon SS, Kim N, Yoo TJ. The effect of vaccination with DNA encoding murine T-cell epitopes on the Der p 1 and 2 induced immunoglobulin E synthesis. Allergy 2001;56:741-8.
149. Kim N, Kwon SS, Lee J, Kim S, Yoo TJ. Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy. Clin Mol Allergy 2006;4:4.
150. Weghofer M, Thomas WR, Kronqvist M, Mari A, Purohit A, Pauli G, Horak F, Grönlund H, van Hage M, Valenta R, Vrtala S. Variability of IgE reactivity profiles among European mite allergic patients. Eur J Clin Invest 2008;38:959-65.
151. Treudler R. Update on in vitro allergy diagnostics. J Dtsch Dermatol Ges 2012;10:89-99.
152. Jeong KY, Hong CS, Yong TS. Recombinant allergens for diagnosis and immunotherapy of allergic disorders, with emphasis on cockroach allergy. Curr Protein Pept Sci 2006;7:57-71.