Structure-selective anisotropy assay for amyloid beta oligomers

ACS Chemical Neuroscience

Volumn 3, Issue 11, 2012, Pages 982-987

  Matveeva, Evgenia G ^a,b   Rudolph, Alan ^b   Moll, Jonathan R ^b   Thompson, Richard B ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Adlyfe Inc   (United States)

Author keywords

Alzheimers disease; fluorescence anisotropy; fluorescence polarization; oligomeric amyloid beta; structure selective assay

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; OLIGOMER; PYRENE DERIVATIVE;

ALZHEIMER DISEASE; ANISOTROPY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; FLUORESCENCE POLARIZATION; MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN CONFORMATION;

AMYLOID BETA-PEPTIDES; ANISOTROPY; HUMANS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PYRENES; SPECTROMETRY, FLUORESCENCE;

EID: 84869760605     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn3001262     Document Type: Article

References (24)

1. Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., and Cotman, C. W. (1993) Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13 (4), 1676-1687.
2. Lacor, P. N., Buniel, M. C., Chang, L., Fernandez, S. J., Gong, Y., Viola, K. L., Lambert, M. P., Velasco, P. T., Bigio, E. H., Finch, C. E., Krafft, G. A., and Klein, W. L. (2004) Synaptic targeting by Alzheimers-related amyloid beta oligomers. J. Neurosci. 24 (45), 10191-10200.
3. Cerpa, W., Dinamarca, M. C., and Inestrosa, N. C. (2008) Structure-function implications in Alzheimers disease: Effect of Abeta oligomers at central synapses. Curr. Alzheimer Res. 5 (3), 233-243.
4. Funke, S. A., Birkmann, E., and Willbold, D. (2009) Detection of amyloid-beta aggregates in body fluids: a suitable method for early diagnosis of Alzheimers disease? Curr. Alzheimer Res. 6 (3), 285-289.
5. Watson, D., Castan̄o, E., Kokjohn, T. A., Kuo, Y. M., Lyubchenko, Y., Pinsky, D., Connolly, E. S., Jr., Esh, C., Luehrs, D. C., Stine, W. B., Rowse, L. M., Emmerling, M. R., and Roher, A. E. (2005) Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimers disease. Neurol. Res. 27, 869-881.
6. Schupf, N., Tang, M. X., Fukuyama, H., Manly, J., Andrews, H., Mehta, P., Ravetch, J., and Mayeux, R. (2008) Peripheral Abeta subspecies as risk biomarkers of Alzheimers disease. Proc. Natl. Acad. Sci. U.S.A. 105 (37), 14052-14057.
7. Rahimi, F., Shanmugam, A., and Bitan, G. (2008) Structurefunction relationships of pre-fibrillar protein assemblies in Alzheimers disease and related disorders. Curr. Alzheimer Res. 5 (3), 3193-3141.
8. Aluise, C. D., Sowell, R. A., and Butterfield, D. A. (2008) Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimers disease. Biochim. Biophys. Acta 1782 (10), 549-558.
9. Fukumoto, H., Tokuda, T., Kasai, T., Ishigami, N., Hidaka, H., Kondo, M., Allsop, D., and Nakagawa, M. (2010) High-molecularweight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients. FASEB J. 24 (8), 2716-2726.
10. van Helmond, Z., Heesom, K., and Love, S. (2009) Characterization of two antibodies to oligomeric Abeta and their use in ELISAs on human brain tissue homogenates. J. Neurosci. Methods 176 (2), 206-212.
11. Klaver, A. C., Patrias, L. M., Coffey, M. P., Finke, J. M., and Loeffler, D. A. (2010) Measurement of anti-Abeta1-42 antibodies in intravenous immunoglobulin with indirect ELISA: the problem of nonspecific binding. J. Neurosci. Methods 187 (2), 263-269.
12. Hillen, H., Barghorn, S., Striebinger, A., Labkovsky, B., Müller, R., Nimmrich, V., Nolte, M. W., Perez-Cruz, C., van der Auwera, I., van Leuven, F., van Gaalen, M., Bespalov, A. Y., Schoemaker, H., Sullivan, J. P., and Ebert, U. (2010) Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies. J. Neurosci. 30 (31), 10369-10379.
13. James, E. A., Schmeltzer, K., and Ligler, F. S. (1996) Detection of endotoxin using an evanescent wave fiber-optic biosensor. Appl. Biochem. Biotechnol. 60 (3), 189-202.
14. Schmid, E. L., Tairi, A. P., Hovius, R., and Vogel, H. (1998) Screening ligands for membrane protein receptors by total internal reflection fluorescence: the 5-HT3 serotonin receptor. Anal. Chem. 70 (7), 1331-1338.
15. Lee, M., and Walt, D. R. (2000) A fiber-optic microarray biosensor using aptamers as receptors. Anal. Biochem. 282, 142-146.
16. Kulagina, N. V., Lassman, M. E., Ligler, F. S., and Taitt, C. R. (2005) Antimicrobial peptides for detection of bacteria in biosensor assays. Anal. Chem. 77 (19), 6504-6508.
17. Kulagina, N. V., Shaffer, K. M., Ligler, F. S., and Taitt, C. R. (2007) Antimicrobial peptides as new recognition molecules for screening challenging species. Sens. Actuators, B 121, 150-157.
18. Grosset, A., Moskowitz, K., Nelsen, C., Pan, T., Davidson, E., and Orser, C. S. (2005) Rapid presymptomatic detection of PrPSc via conformationally responsive palindromic PrP peptides. Peptides 26 (11), 2193-2200.
19. Tcherkasskaya, O., Davidson, E.A.., Schmerr, M. J., and Orser, C. S. (2005) Conformational biosensor for diagnosis of prion diseases. Biotechnol. Lett. 27 (9), 671-675.
20. Pan, T., Sethi, J., Nelsen, C., Rudolph, A., Cervenakova, L., Brown, P., and Orser, C. S. (2007) Detection of misfolded prion protein in blood with conformationally sensitive peptides. Transfusion 47 (8), 1418-1425.
21. Barghorn, S., Nimmrich, V., Striebinger, A., Krantz, C., Keller, P., Janson, B., Bahr, M., Schmidt, M., Bitner, R. S., Harlan, J., Barlow, E., Ebert, U., and Hillen, H. (2005) Globular amyloid beta-peptide oligomer?A homogenous and stable neuropathological protein in Alzheimers disease. J. Neurochem. 95 (3), 834-847.
22. Thompson, R. B., and Gratton, E. (1988) Phase fluorimetric method for determination of standard lifetimes. Anal. Chem. 60, 670-674.
23. Forster, T., and Kasper, K. (1954) Ein konzentrationsumschlag der fluoreszenz des pyrens. Z. Phys. Chem. (Neue Folge) 1, 275-277.
24. Lakowicz, J.R. (2006) Principles of Fluorescence Spectroscopy 3rd revised ed., Springer-Verlag, Inc., New York.