Nicotinic acetylcholine receptor signaling in atherogenesis

Atherosclerosis

Volumn 225, Issue 2, 2012, Pages 264-273

  Santanam, Nalini ^a   Thornhill, Brent A ^a   Lau, Jamie K ^a   Crabtree, Clayton M ^a   Cook, Carla R ^a   Brown, Kathleen C ^a   Dasgupta, Piyali ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atherogenesis; NAChR; Nicotine; Signaling; VSMC

Indexed keywords

4 CHLORO N (3 QUINUCLIDINYL)BENZAMIDE; ALPHA BUNGAROTOXIN; GROWTH FACTOR; HEXAMETHONIUM; LIGAND; METHYLLYCACONITINE; NICOTINE; NICOTINE GUM; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; NITROSAMINE;

ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL; CELL CULTURE; DENDRITIC CELL; DRUG MECHANISM; ENVIRONMENTAL FACTOR; FEASIBILITY STUDY; HUMAN; IMMUNOCOMPETENT CELL; INFORMATION; LYMPHOCYTE FUNCTION; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SMOKING CESSATION; T LYMPHOCYTE; TOBACCO; UPREGULATION;

ANIMALS; ATHEROSCLEROSIS; BLOOD VESSELS; CARDIOVASCULAR AGENTS; DRUG DESIGN; HUMANS; LIGANDS; NICOTINE; NICOTINIC AGONISTS; NITROSAMINES; RECEPTORS, NICOTINIC; RISK FACTORS; SIGNAL TRANSDUCTION; SMOKING; TOBACCO USE CESSATION PRODUCTS;

EID: 84869505434     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.07.041     Document Type: Review

References (58)

1. Stylianou I.M., Bauer R.C., Reilly M.P., et al. Genetic basis of atherosclerosis: insights from mice and humans. Circ Res 2012, 110:337-355.
2. Parthasarathy S., Santanam N., Ramachandran S., et al. Oxidants and antioxidants in atherogenesis. An appraisal. J Lipid Res 1999, 40:2143-2157.
3. Doyle B., Caplice N. Plaque neovascularization and antiangiogenic therapy for atherosclerosis. J Am Coll Cardiol 2007, 49:2073-2080.
4. Unverdorben M., von Holt K., Winkelmann B.R. Smoking and atherosclerotic cardiovascular disease: part II: role of cigarette smoking in cardiovascular disease development. Biomark Med 2009, 3:617-653.
5. Ambrose J.A., Barua R.S. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol 2004, 43:1731-1737.
6. Lee J., Cooke J.P. The role of nicotine in the pathogenesis of atherosclerosis. Atherosclerosis 2011, 215:281-283.
7. Egleton R.D., Brown K.C., Dasgupta P. Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases. Pharmacol Ther 2009, 121:205-223.
8. Heeschen C., Jang J.J., Weis M., et al. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 2001, 7:833-839.
9. Gotti C., Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 2004, 74:363-396.
10. Arredondo J., Chernyavsky A.I., Webber R.J., et al. Biological effects of SLURP-1 on human keratinocytes. J Invest Dermatol 2005, 125:1236-1241.
11. Arredondo J., Chernyavsky A.I., Jolkovsky D.L., et al. SLURP-2: a novel cholinergic signaling peptide in human mucocutaneous epithelium. J Cell Physiol 2006, 208:238-245.
12. Schuller H.M., Tithof P.K., Williams M., et al. The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res 1999, 59:4510-4515.
13. Titof P.K., Elgayyar M., Schuller H.M., et al. 4- (Methylnitrosoamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis in endothelial cells. Am J Physiol Heart Circ Physiol 2001, 281:H1946-H1954.
14. Dasgupta P., Chellappan S.P. Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle 2006, 5:2324-2328.
15. Shin V.Y., Wu W.K., Chu K.M., et al. Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol Sci 2007, 96:21-29.
16. Jacob T., Clouden N., Hingorani A., et al. The effect of cotinine on telomerase activity in human vascular smooth muscle cells. J Cardiovasc Surg (Torino) 2009, 50:345-349.
17. Li S., Zhao T., Xin H., et al. Nicotinic acetylcholine receptor alpha7 subunit mediates migration of vascular smooth muscle cells toward nicotine. J Pharmacol Sci 2004, 94:334-338.
18. Di Luozzo G., Pradhan S., Dhadwal A.K., et al. Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration. Atherosclerosis 2005, 178:271-277.
19. Kanda Y., Watanabe Y. Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells. Life Sci 2007, 80:1409-1414.
20. Cucina A., Sapienza P., Corvino V., et al. Nicotine induces platelet-derived growth factor release and cytoskeletal alteration in aortic smooth muscle cells. Surgery 2000, 127:72-78.
21. Stein J.J., Seymour K.A., Maier K.G., et al. The effects of nicotine on vascular smooth muscle cell chemotaxis induced by thrombospondin-1 and fibronectin. Am J Surg 2011, 202:545-548.
22. Cucina A., Fuso A., Coluccia P., et al. Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor. J Surg Res 2008, 150:227-235.
23. Cucina A., Sapienza P., Corvino V., et al. Nicotine-induced smooth muscle cell proliferation is mediated through bFGF and TGF-beta 1. Surgery 2000, 127:316-322.
24. Strohschneider T., Oberhoff M., Hanke H., et al. Effect of chronic nicotine delivery on the proliferation rate of endothelial and smooth muscle cells in experimentally induced vascular wall plaques. Clin Investig 1994, 72:908-912.
25. Cooke J.P. Angiogenesis and the role of the endothelial nicotinic acetylcholine receptor. Life Sci 2007, 80:2347-2351.
26. Pillai S., Chellappan S. Proportional, variant7 nicotinic acetylcholine receptor subunit in angiogenesis and epithelial to mesenchymal transition. Curr Drug Targets 2012.
27. Lau P.P., Li L., Merched A.J., et al. Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice. Arterioscler Thromb Vasc Biol 2006, 26:143-149.
28. Catanzaro D.F., Zhou Y., Chen R., et al. Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine. Cardiovasc Toxicol 2007, 7:192-201.
29. Ruixing Y., Qi B., Tangwei L., et al. Effects of nicotine on angiogenesis and restenosis in a rabbit model. Cardiology 2007, 107:122-131.
30. Heeschen C., Weis M., Cooke J.P. Nicotine promotes arteriogenesis. J Am Coll Cardiol 2003, 41:489-496.
31. Booyse F.M., Osikowicz G., Quarfoot A.J. Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium. Am J Pathol 1981, 102:229-238.
32. Ashakumary L., Vijayammal P.L. Effect of nicotine on lipoprotein metabolism in rats. Lipids 1997, 32:311-315.
33. Chattopadhyay K., Chattopadhyay B.D. Effect of nicotine on lipid profile, peroxidation & antioxidant enzymes in female rats with restricted dietary protein. Indian J Med Res 2008, 127:571-576.
34. Cluette-Brown J., Mulligan J., Doyle K., et al. Oral nicotine induces an atherogenic lipoprotein profile. Proc Soc Exp Biol Med 1986, 182:409-413.
35. Thorgeirsson T.E., Geller F., Sulem P., et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008, 452:638-642.
36. Cooke J.P., Ghebremariam Y.T. Endothelial nicotinic acetylcholine receptors and angiogenesis. Trends Cardiovasc Med 2008, 18:247-253.
37. Wu J.C., Chruscinski A., De Jesus Perez V.A., et al. Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. J Cell Biochem 2009, 108:433-446.
38. Wada T., Naito M., Kenmochi H., et al. Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Endocrinology 2007, 148:790-799.
39. Albaugh G., Bellavance E., Strande L., et al. Nicotine induces mononuclear leukocyte adhesion and expression of adhesion molecules, VCAM and ICAM, in endothelial cells in vitro. Ann Vasc Surg 2004, 18:302-307.
40. Cooke J.P., Bitterman H. Nicotine and angiogenesis: a new paradigm for tobacco-related diseases. Ann Med 2004, 36:33-40.
41. Alamanda V., Singh S., Lawrence N.J., et al. Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity. Biochem Biophys Res Commun 2012, 418:56-61.
42. Wilund K.R., Rosenblat M., Chung H.R., et al. Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development. Biochem Biophys Res Commun 2009, 390:148-154.
43. Zhang G., Marshall A.L., Thomas A.L., et al. In vivo knockdown of nicotinic acetylcholine receptor alpha1 diminishes aortic atherosclerosis. Atherosclerosis 2011, 215:34-42.
44. Aicher A., Heeschen C., Mohaupt M., et al. Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions. Circulation 2003, 107:604-611.
45. Shanker G., Kontos J.L., Eckman D.M., et al. Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts. J Thromb Thrombolysis 2006, 22:213-220.
46. Schedel A., Thornton S., Schloss P., et al. Human platelets express functional alpha7-nicotinic acetylcholine receptors. Arterioscler Thromb Vasc Biol 2011, 31:928-934.
47. Vazquez-Padron R.I., Mateu D., Rodriguez-Menocal L., et al. Novel role of Egr-1 in nicotine-related neointimal formation. Cardiovasc Res 2010, 88:296-303.
48. MacLellan W.R., Wang Y., Lusis A.J. Systems-based approaches to cardiovascular disease. Nat Rev Cardiol 2012, 9:172-184.
49. Kang H., Hata A. MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin Hematol 2012.
50. Yamakawa K., Kuno T., Hashimoto N., et al. Molecular analysis of carcinogen-induced rodent lung tumors: involvement of microRNA expression and Kralphas or Egfr mutations. Mol Med Rep 2010, 3:141-147.
51. Maegdefessel L., Azuma J., Toh R., et al. MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med 2012, 4. 122ra122.
52. Zhang G., Kernan K.A., Thomas A., et al. A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. J Biol Chem 2009, 284:29050-29064.
53. Wessler I.K., Kirkpatrick C.J. The non-neuronal cholinergic system: an emerging drug target in the airways. Pulm Pharmacol Ther 2001, 14:423-434.
54. Zhen Y., Ruixing Y., Qi B., et al. Nicotine potentiates vascular endothelial growth factor expression in balloon-injured rabbit aortas. Growth Factors 2008, 26:284-292.
55. Bucerius J., Manka C., Schmaljohann J., et al. Feasibility of [(18)F]-2-fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivo. JACC Cardiovasc Imaging 2012, 5:528-536.
56. Cooke J.P. Imaging vascular nicotine receptors: a new window onto vascular disease. JACC Cardiovasc Imaging 2012, 5:537-539.
57. Brown K.C., Lau J.K., Dom A.M., et al. MG624, an alpha7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway. Angiogenesis 2012, 15:99-114.
58. Pittilo M.R. Cigarette smoking, endothelial injury and cardiovascular disease. Int J Exp Pathol 2000, 81:219-230.