MG624, an α7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway

Angiogenesis

Volumn 15, Issue 1, 2012, Pages 99-114

  Brown, Kathleen C ^a   Lau, Jamie K ^a   Dom, Aaron M ^a   Witte, Theodore R ^a   Luo, Haitao ^b   Crabtree, Clayton M ^a   Shah, Yashoni H ^c   Shiflett, Brandon S ^a   Marcelo, Aileen J ^a   Proper, Nancy A ^a   Hardman, W Elaine ^a   Egleton, Richard D ^a   Chen, Yi Charlie ^b   Mangiarua, Elsa I ^a   Dasgupta, Piyali ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Alderson Broaddus College   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

7 nAChR; Angiogenesis; FGF2; MG624; Nicotine; SCLC

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; EARLY GROWTH RESPONSE FACTOR 1; FIBROBLAST GROWTH FACTOR 2; STILONIUM IODIDE; UNCLASSIFIED DRUG; BUNGAROTOXIN RECEPTOR; EGR1 PROTEIN, HUMAN; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; QUATERNARY AMMONIUM DERIVATIVE; STILBENE DERIVATIVE; TRIETHYL (BETA 4 STILBENOXYETHYL)AMMONIUM; TRIETHYL-(BETA-4-STILBENOXYETHYL)AMMONIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MALE; MICROVASCULAR ENDOTHELIAL CELL; MODEL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; RAT; TRANSCRIPTION REGULATION; ANGIOGENESIS; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CHICKEN; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; LUNG; METABOLISM; MICROVASCULATURE; NUDE MOUSE; SECRETION; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANIMALS; CELL PROLIFERATION; CHICKENS; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTOR 2; HUMANS; LUNG; MICE; MICE, NUDE; MICROVESSELS; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PHYSIOLOGIC; NICOTINE; NICOTINIC ANTAGONISTS; QUATERNARY AMMONIUM COMPOUNDS; RATS; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION; STILBENES;

EID: 84861540638     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-011-9246-9     Document Type: Article

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