De novo engineering of a human cystathionine-γ-lyase for systemic l-methionine depletion cancer therapy

ACS Chemical Biology

Volumn 7, Issue 11, 2012, Pages 1822-1829

  Stone, Everett ^a   Paley, Olga ^a   Hu, Jian ^c   Ekerdt, Barbara ^a   Cheung, Nai Kong ^c   Georgiou, George ^a,b  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTATHIONINE GAMMA LYASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHIONINE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CANCER THERAPY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG HALF LIFE; ENZYME ENGINEERING; FEMALE; HUMAN; HYDROPHOBICITY; IC 50; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF DETECTION; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; XENOGRAFT;

AMINO ACID SUBSTITUTION; ANIMALS; CARBON-SULFUR LYASES; CELL LINE, TUMOR; CYSTATHIONINE GAMMA-LYASE; ENZYME THERAPY; HUMANS; METHIONINE; MICE; MICE, NUDE; MODELS, MOLECULAR; NEUROBLASTOMA; PROTEIN ENGINEERING; PSEUDOMONAS PUTIDA;

BACTERIA (MICROORGANISMS); MUS; NARCISSUS LATENT VIRUS; PRIMATES; PSEUDOMONAS PUTIDA;

EID: 84869462148     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300335j     Document Type: Article

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