Effect of ciprofloxacin on lethal and sublethal challenge with endotoxin and on early cytokine responses in a murine in vivo model

Journal of Antimicrobial Chemotherapy

Volumn 50, Issue 1, 2002, Pages 51-58

  Purswani, Murli U ^a   Eckert, Susan J ^a   Arora, Harman K ^a   Noel, Gary J ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Ciprofloxacin; Cytokine response; Endotoxin; Fluoroquinolone; Immune response; in vivo; Inflammatory response; Innate immunity; Mortality; Murine

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CIPROFLOXACIN; CYTOKINE; ENDOTOXIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; ENDOTOXIN, ESCHERICHIA COLI; INTERLEUKIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEATH; DISEASE COURSE; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; LETHAL DOSE; LETHALITY; MOUSE; NONHUMAN; PROTECTION; PROTEIN BLOOD LEVEL; PROVOCATION TEST; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; DISEASE MODEL; ENDOTOXEMIA; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION;

ANIMALS; ANTI-INFECTIVE AGENTS; CIPROFLOXACIN; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; ENDOTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035996093     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkf091     Document Type: Article

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