Calcium channel blockers prevent endothelial cell activation in response to necrotic trophoblast debris: Possible relevance to pre-eclampsia

Cardiovascular Research

Volumn 96, Issue 3, 2012, Pages 484-493

  Chen, Qi ^a,b,c   Guo, Fang ^c   Liu, Shurong ^c   Xiao, Jianping ^b   Wang, Chao ^c   Snowise, Saul ^d   Stone, Peter R ^a,d   Chamley, Lawrence W ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b NANJING MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d AUCKLAND CITY HOSPITAL   (New Zealand)

Author keywords

Endothelial cell activation; Nifedipine; Pre eclampsia; Trophoblastic debris; Verapamil

Indexed keywords

2,2' (HYDROXYNITROSOHYDRAZONO)BISETHANIMINE; CALCIUM CHANNEL BLOCKING AGENT; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; NITRIC OXIDE DONOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VERAPAMIL;

ADOLESCENT; ADULT; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MONOCYTE; NECROTIC TROPHOBLASTIC DEBRIS; PHAGOCYTOSIS; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM; TROPHOBLAST;

ADOLESCENT; ADULT; CALCIUM CHANNEL BLOCKERS; CASE-CONTROL STUDIES; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; E-SELECTIN; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; MIDDLE AGED; NECROSIS; NIFEDIPINE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; PHAGOCYTOSIS; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TIME FACTORS; TISSUE CULTURE TECHNIQUES; TRANSFORMING GROWTH FACTOR BETA1; TROPHOBLASTS; VERAPAMIL; YOUNG ADULT;

EID: 84869440839     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs279     Document Type: Article

References (38)

1. Clark SL, Belfort MA, Dildy GA, Herbst MA, Meyers JA, Hankins GD. Maternal death in the 21st century: causes, prevention, and relationship to cesarean delivery. Am J Obstet Gynecol 2008;199:36.e31-36.e35; discussion 91-92 e7-11.
2. Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens 1991;4:700-708.
3. Askelund KJ, Chamley LW. Trophoblast deportation part I: review of the evidence demonstrating trophoblast shedding and deportation during human pregnancy. Placenta 2011;32:716-723.
4. Schmorl G. Pathologisch-Anatomische Untersuchungen Uber Puerperal-Eklampsie. Leipzig: Verlag von FC Vogel; 1893.
5. Attwood HD, Park WW. Embolism to the lungs by trophoblast. J Obstet Gynaecol Br Commonw 1961;68:611-617.
6. Jaameri KE, Koivuniemi AP, Carpen EO. Occurrence of trophoblasts in the blood of toxaemic patients. Gynaecologia 1965;160:315-320.
7. Chua S, Wilkins T, Sargent I, Redman C. Trophoblast deportation in pre-eclamptic pregnancy. Br J Obstet Gynaecol 1991;98:973-979.
8. Chen Q, Chen L, Liu B, Vialli C, Stone P, Ching LM et al. The role of autocrine TGFbeta1 in endothelial cell activation induced by phagocytosis of necrotic tropho-blasts: a possible role in the pathogenesis of pre-eclampsia. J Pathol 2010;221:87-95.
9. Chen Q, Ding JX, Liu B, Stone P, Feng YJ, Chamley LW. Spreading endothelial cell dysfunction in response to necrotic trophoblasts. Soluble factors released from endo-thelial cells that have phagocytosed necrotic shed trophoblasts reduce the proliferation of additional endothelial cells. Placenta 2010;31:75-80.
10. Chen Q, Stone P, Ching LM, Chamley L. A role for interleukin-6 in spreading endo-thelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia. J Pathol 2009;217:122-130.
11. Chen Q, Stone PR, McCowan LM, Chamley LW. Phagocytosis of necrotic but not apoptotic trophoblasts induces endothelial cell activation. Hypertension 2006;47:116-121. (Pubitemid 43177824)
12. Rey E, LeLorier J, Burgess E, Lange IR, Leduc L. Report of the Canadian Hypertension Society consensus conference.3. Pharmacologic treatment of hypertensive disorders in pregnancy. Can Med Assoc J 1997;157:1245-1254.
13. Brown MA, Hague WM, Higgins J, Lowe S, McCowan L, Oats J et al. The detection, investigation and management of hypertension in pregnancy: executive summary. Aust N Z J Obstet Gynaecol 2000;40:133-138. (Pubitemid 30323583)
14. Magee LA, Miremadi S, Li J, Cheng C, Ensom MHH, Carleton B et al. Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia. Am J Obstet Gynecol 2005;193:153-163. (Pubitemid 40991839)
15. Raheem IA, Saaid R, Omar SZ, Tan PC. Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial. BJOG 2012;119:78-85.
16. Von Dadelszen P, Magee LA. Antihypertensive medications in management of gesta-tional hypertension-preeclampsia. Clin Obstet Gynecol 2005;48:441-459. (Pubitemid 40605146)
17. Ueng KC, Lin MC, Chan KC, Lin CS. Nifedipine gastrointestinal therapeutic system: an overview of its antiatherosclerotic effects. Expert Opin Drug Metab Toxicol 2007;3:769-780.
18. Waters D, Lesperance J, Francetich M, Causey D, Theroux P, Chiang YK et al. A controlled clinical-trial to assess the effect of a calcium-channel blocker on the progression of coronary atherosclerosis. Circulation 1990;82:1940-1953.
19. Lichtlen PR, Hugenholtz PG, Rafflenbeul W, Hecker H, Jost S, Deckers JW. Retardation of angiographic progression of coronary-artery disease by nifedipine-results of the international nifedipine trial on antiatherosclerotic therapy (Intact). Lancet 1990;335:1109-1113. (Pubitemid 20159424)
20. Mak IT, Kramer JH, Weglicki WB. Antioxidant properties of active and inactive isomers of nicardipine in cardiac membranes, endothelial-cells, and perfused rat hearts. Coron Artery Dis 1992;3:1095-1103.
21. Chen XN, Xu J, Feng Z, Fan M, Han JY, Yang Z. Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation. Acta Pharmacol Sin 2010;31:813-820.
22. Yamagishi S, Takeuchi M. Nifedipine inhibits gene expression of receptor for advanced glycation end products (RAGE) in endothelial cells by suppressing reactive oxygen species generation. Drugs Exp Clin Res 2004;30:169-175. (Pubitemid 39487685)
23. Yamagishi S, Takeuchi M. Nifedipine inhibits tumor necrosis factor-alpha-induced leukocyte adhesion to endothelial cells by suppressing vascular cell adhesion molecule-1 (VCAM-1) expression. Drugs Exp Clin Res 2004;30:163-168. (Pubitemid 39487684)
24. Nomura S, Shouzu A, Omoto S, Nishikawa M, Iwasaka T. Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. Thromb Res 2005;115:277-285.
25. Abumaree MH, Stone PR, Chamley LW. An in vitro model of human placental tropho-blast deportation/shedding. Mol Hum Reprod 2006;12:687-694. (Pubitemid 44605601)
26. Endresen MJ, Morris JM, Nobrega AC, Buckley D, Linton EA, Redman CW. Serum from preeclamptic women induces vascular cell adhesion molecule-1 expression on human endothelial cells in vitro: a possible role of increased circulating levels of free fatty acids. Am J Obstet Gynecol 1998;179:665-670. (Pubitemid 28447243)
27. Branch DW, Dudley DJ, LaMarche S, Mitchell MD. Sera from preeclamptic patients contain factor(s) that stimulate prostacyclin production by human endothelial cells. Prostaglandins Leukot Essent Fatty Acids 1992;45:191-195.
28. Haller H, Ziegler EM, Homuth V, Drab M, Eichhorn J, Nagy Z et al. Endothelial adhesion molecules and leukocyte integrins in preeclamptic patients. Hypertension 1997;29:291-296. (Pubitemid 27074058)
29. Magee LA, von Dadelszen P. The management of severe hypertension. Semin Perinatol 2009;33:138-142.
30. Passacquale G, Desideri G, Croce G, Murgo S, Mancarelli MM, Zazzeroni F et al. Ni-fedipine improves the migratory ability of circulating endothelial progenitor cells depending on manganese superoxide dismutase upregulation. J Hypertens 2008;26:737-746. (Pubitemid 351354922)
31. Taddei S, Virdis A, Ghiadoni L, Magagna A, Favilla S, Pompella A et al. Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension. Hypertension 2001;37:943-948. (Pubitemid 32221618)
32. Xie C, Yao MZ, Liu JB, Xiong LK. A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia. Cytokine 2011;56:550-559.
33. Covone AE, Johnson PM, Mutton D, Adinolfi M. Trophoblast cells in peripheral-blood from pregnant-women. Lancet 1984;2:841-843.
34. Ikle FA. Dissemination of syncytial trophoblastic cells in the maternal blood stream during pregnancy. Bull Schweiz Akad Med Wiss 1964;20:62-72.
35. Albrecht EW, Stegeman CA, Heeringa P, Henning RH, van Goor H. Protective role of endothelial nitric oxide synthase. J Pathol 2003;199:8-17. (Pubitemid 36061187)
36. Ding Y, Vaziri ND. Nifedipine and diltiazem but not verapamil up-regulate endothelial nitric-oxide synthase expression. J Pharmacol Exp Ther 2000;292:606-609. (Pubitemid 30067423)
37. Brovkovych VV, Kalinowski L, Muller-Peddinghaus R, Malinski T. Synergistic antihyper-tensive effects of nifedipine on endothelium : concurrent release of NO and scavenging of superoxide. Hypertension 2001;37:34-39. (Pubitemid 32064236)
38. Yamamoto E, Nakamura T, Kataoka K, Tokutomi Y, Dong YF, Fukuda M et al. Nifedi-pine prevents vascular endothelial dysfunction in a mouse model of obesity and type 2 diabetes, by improving eNOS dysfunction and dephosphorylation. Biochem Biophys Res Commun 2010;403:258-263.