The role of autocrine TGFβ1 in endothelial cell activation induced by phagocytosis of necrotic trophoblasts: A possible role in the pathogenesis of pre-eclampsia

Journal of Pathology

Volumn 221, Issue 1, 2010, Pages 87-95

  Chen, Qi ^a,b   Chen, Limei ^b   Liu, Bonnia ^a   Vialli, Chez ^a   Stone, Peter ^a   Ching, Lai Ming ^c   Chamley, Lawrence ^a,d  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d GREEN LANE HOSPITAL   (New Zealand)

Author keywords

Endothelial; IL 6; Pre eclampsia; TGF ; Trophoblast

Indexed keywords

ENDOGLIN; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; RECOMBINANT PROTEIN; TGFB1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; EXPLANT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOTHESIS; PATHOGENESIS; PHAGOCYTOSIS; PLACENTA; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TROPHOBLAST; CELL CULTURE; CULTURE MEDIUM; DRUG EFFECT; FEMALE; METABOLISM; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; VASCULAR ENDOTHELIUM;

ANTIGENS, CD; AUTOCRINE COMMUNICATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INTERLEUKIN-6; NECROSIS; PHAGOCYTOSIS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; TROPHOBLASTS;

EID: 77951009874     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2690     Document Type: Article

References (28)

1. Clark SL, Belfort MA, Dildy GA, Herbst MA, Meyers JA, Hankins GD. Maternal death in the 21st century: causes, prevention, and relationship to cesarean delivery. Am J Obstet Gynecol 2008; 199: 36, e31-35; discussion, 91-132, e7-11.
2. Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens 1991; 4: 700-708.
3. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161: 1200-1204.
4. Madazli R, Aydin S, Uludag S, Vildan O, Tolun N. Maternal plasma levels of cytokines in normal and preeclamptic pregnancies and their relationship with diastolic blood pressure and fibronectin levels. Acta Obstet Gynecol Scand 2003; 82: 797-802. (Pubitemid 37082907)
5. Greer IA, Lyall F, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol 1994; 84: 937-940. (Pubitemid 24360251)
6. Dagdeviren A, Muftuoglu SF, Cakar AN, Ors U. Endoglin (CD 105) expression in human lymphoid organs and placenta. Ann Anat 1998; 180: 461-469. (Pubitemid 28466541)
7. ten Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 2008; 11: 79-89; DOI: 10.1007/s10456-008-9101-9.
8. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al . Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006; 355: 992-1005. (Pubitemid 44343543)
9. Chen Q, Stone P, Ching LM, Chamley L. A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia. J Pathol 2009; 217: 122-130.
10. Chen Q, Stone PR, McCowan LM, Chamley LW. Phagocytosis of necrotic but not apoptotic trophoblasts induces endothelial cell activation. Hypertension 2006; 47: 116-121. (Pubitemid 43177824)
11. Rossi JF, Fegueux N, Lu ZY, Legouffe E, Exbrayat C, Bozonnat MC, et al . Optimizing the use of anti-interleukin-6 monoclonal antibody with dexamethasone and 140 mg/m2 of melphalan in multiple myeloma: results of a pilot study including biological aspects. Bone Marrow Transpl 2005; 36: 771-779. (Pubitemid 41613299)
12. Lu ZY, Brailly H, Rossi JF, Wijdenes J, Bataille R, Klein B. Overall interleukin-6 production exceeds 7 mg/day in multiple myeloma complicated by sepsis. Cytokine 1993; 5: 578-582. (Pubitemid 24072060)
13. Abumaree MH, Stone PR, Chamley LW. An in vitro model of human placental trophoblast deportation/shedding. Mol Hum Reprod 2006; 12: 687-694. (Pubitemid 44605601)
14. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308: 1592-1594.
15. Attwood HD, Park WW. Embolism to the lungs by trophoblast. J Obstet Gynaecol Br Commonw 1961; 68: 611-617.
16. Djurovic S, Schjetlein R, Wisloff F, Haugen G, Husby H, Berg K. Plasma concentrations of Lp(a) lipoprotein and TGF-β1 are altered in preeclampsia. Clin Genet 1997; 52: 371-376. (Pubitemid 28068627)
17. Benian A, Madazli R, Aksu F, Uzun H, Aydin S. Plasma and placental levels of interleukin-10, transforming growth factor-β1, and epithelial cadherin in preeclampsia. Obstet Gynecol 2002; 100: 327-331. (Pubitemid 34874798)
18. Muy-Rivera M, Sanchez SE, Vadachkoria S, Qiu C, Bazul V, Williams MA. Transforming growth factor-β1 (TGF-β1) in plasma is associated with preeclampsia risk in Peruvian women with systemic inflammation. Am J Hypertens 2004; 17: 334-338. (Pubitemid 38446848)
19. Naicker T, Khedun SM, Moodley J. Transforming growth factor β(1) levels in platelet depleted plasma in African women with preeclampsia. J Obstet Gynaecol 2002; 22: 279-282. (Pubitemid 34628150)
20. Lim JH, Kim SY, Park SY, Lee MH, Yang JH, Kim MY, et al . Soluble endoglin and transforming growth factor-β1 in women who subsequently developed preeclampsia. Prenat Diagn 2009; 29: 471-476.
21. Peracoli MT, Menegon FT, Borges VT, de Araujo Costa RA, Thomazini-Santos IA, Peracoli JC. Platelet aggregation and TGF-β(1) plasma levels in pregnant women with preeclampsia. J Reprod Immunol 2008; 79: 79-84.
22. Walia B, Wang L, Merlin D, Sitaraman SV. TGF-β down-regulates IL-6 signaling in intestinal epithelial cells: critical role of SMAD-2. FASEB J 2003; 17: 2130-2132.
23. Boivin GP, O'Toole BA, Orsmby IE, Diebold RJ, Eis MJ, Doetschman T, et al . Onset and progression of pathological lesions in transforming growth factor-β1-deficient mice. Am J Pathol 1995; 146: 276-288.
24. Bonney EA, Matzinger P. The maternal immune system's interaction with circulating fetal cells. J Immunol 1997; 158: 40-47. (Pubitemid 127483839)
25. Lebrin F, Deckers M, Bertolino P, Ten Dijke P. TGF-β receptor function in the endothelium. Cardiovasc Res 2005; 65: 599-608.
26. Munaut C, Lorquet S, Pequeux C, Blacher S, Berndt S, Frankenne F, et al . Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast. Hum Reprod 2008; 23: 1407-1415. (Pubitemid 351770590)
27. Graham CH, Lysiak JJ, McCrae KR, Lala PK. Localization of transforming growth factor-β at the human fetal-maternal interface: role in trophoblast growth and differentiation. Biol Reprod 1992; 46: 561-572.
28. Lockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, et al . Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells. Am J Pathol 2008; 172: 1571-1579. (Pubitemid 351793350)