Electrophilic adduction of ubiquitin activating enzyme E1 by N, N-diethyldithiocarbamate inhibits ubiquitin activation and is accompanied by striatal injury in the rat

Chemical Research in Toxicology

Volumn 25, Issue 11, 2012, Pages 2310-2321

  Viquez, Olga M ^a   Caito, Samuel W ^a   McDonald, W Hayes ^b   Friedman, David B ^b   Valentine, William M ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CARBONYL DERIVATIVE; CATECHOL; CYSTEINE; DIETHYLDITHIOCARBAMIC ACID; MYELIN; TAU PROTEIN; TYROSINE 3 MONOOXYGENASE; UBIQUITIN; UBIQUITIN ACTIVATING ENZYME E1; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; BRAIN INJURY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ELECTROPHILIC ADDUCTION; ENZYME ACTIVITY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEOMICS; RAT; STRIATAL INJURY; TANDEM MASS SPECTROMETRY;

ANIMALS; CORPUS STRIATUM; DITIOCARB; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MALE; MODELS, MOLECULAR; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN-ACTIVATING ENZYMES;

ANIMALIA; RATTUS;

EID: 84869408597     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300198h     Document Type: Article

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