Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling

Nature Communications

Volumn 3, Issue , 2012, Pages

  Pastuhov, Strahil Iv ^a   Fujiki, Kota ^a   Nix, Paola ^b   Kanao, Shuka ^a   Bastiani, Michael ^b   Matsumoto, Kunihiro ^a   Hisamoto, Naoki ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ANANDAMIDE; ARACHIDONOYL ETHANOLAMIDE; ENDOCANNABINOID; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID AMIDASE; FATTY ACID AMIDE HYDROLASE 1; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN KGB 1; PROTEIN MLK 1; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; FATTY ACID; GROWTH RATE; INJURY; LASER METHOD; NEMATODE; NEUROLOGY; PROTEIN; SIGNALING;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DEGRADATION; ENZYME PHOSPHORYLATION; NERVE FIBER REGENERATION; NERVE FIBER TRANSECTION; NONHUMAN; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANIMALS; ARACHIDONIC ACIDS; AXONS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; ENDOCANNABINOIDS; GENES, HELMINTH; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NERVE REGENERATION; POLYUNSATURATED ALKAMIDES; PROTEIN-TYROSINE KINASES;

CAENORHABDITIS ELEGANS;

EID: 84869398123     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2136     Document Type: Article

References (37)

1. Case, L. C. & Tessier-Lavigne, M. Regeneration of the adult central nervous system. Curr. Biol. 15, R749-753 (2005).
2. Lee, J. K. et al. Reassessment of corticospinal tract regeneration in Nogo-defcient mice. J. Neurosci 29, 8649-8654 (2009).
3. Lee, J. K. & Zheng, B. Role of myelin-associated inhibitors in axonal repair afer spinal cord injury. Exp. Neurol. 235, 33-42 (2012).
4. Yanik, M. F. et al. Neurosurgery: functional regeneration afer laser axotomy Nature 432, 822 (2004). (Pubitemid 40037136)
5. Hammarlund, M., Nix, P., Hauth, L., Jorgensen, E. M. & Bastiani, M. Axon regeneration requires a conserved MAP kinase pathway Science 323, 802-806 (2009).
6. Yan, D., Wu, Z., Chisholm, A. D. & Jin, Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell 138, 1005-1018 (2009).
7. Nix, P., Hisamoto, N., Matsumoto, K. & Bastiani, M. Axon regeneration requires co-activation of p38 and JNK MAPK pathways. Proc. Natl Acad. Sci. USA 108, 10738-10743 (2011).
8. Mizuno, T. et al. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 23, 2226-2234 (2004). (Pubitemid 38833232)
9. Li, C. et al. The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade. Nat Neurosci. 15, 551-557 (2012).
10. Kenney A. M. & Kocsis, J. D. Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia In vivo. J. Neurosci. 15, 1318-1328 (1998). (Pubitemid 28082417)
11. Lindwall, C., Dahlin, L., Lundborg, G. & Kanje, M. Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neurons. Mol. Cell Neurosci 27, 267-279 (2004). (Pubitemid 39433841)
12. Barnat, M. et al. Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration. J. Neurosci. 30, 7804-7816 (2010).
13. Lucanic, M. et al. N-acylethanolamine signalling mediates the efect of diet on lifespan in Caenorhabditis elegans. Nature 473, 226-231 (2011).
14. Di Marzo, V., Bifulco, M. & Petrocellis, L. D. The endocannabinoid system and its therapeutic exploitation. Nat Rev. Drug Discov. 3, 771-784 (2004). (Pubitemid 39242829)
15. Berghuis, P. et al. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science 316, 1212-1216 (2007). (Pubitemid 46880959)
16. Cravatt, B. F. et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384, 83-87 (1996). (Pubitemid 26374593)
17. Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C. & Bonner, T. I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564 (1990).
18. Munro, S., Tomas, K. L. & Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365, 61-65 (1993). (Pubitemid 23305569)
19. McPartland, J. M. & Glass, M. Functional mapping of cannabinoid receptor homologs in mammals, other vertebrates, and invertebrates. Gene 312, 297-303 (2003). (Pubitemid 37338135)
20. Mendel, J. E. et al. Participation of the protein Go in multiple aspects of behaviour in C. elegans. Science 267, 1652-1655 (1995).
21. Segalat, L., Elkes, D. A. & Kaplan, J. M. Modulation of serotonin-controlled behaviours by Go in Caenorhabditis elegans. Science 267, 1648-1651 (1995).
22. Miller, K. G., Emerson, M. D. & Rand, J. B. Goα and diacylglycerol kinase negatively regulate the Gqα pathway in C. elegans. Neuron 24, 323-333 (1999). (Pubitemid 29508407)
23. Hajdu-Cronin, Y M., Chen, W. J., Paticoglou, G., Koelle, M. R. & Sternberg, P. W. Antagonism between Goα and Gqα in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goα signaling and regulates Gqα activity Genes Dev. 13, 1780-1793 (1999). (Pubitemid 29353046)
24. Lackner, M. R., Nurrish, S. J. & Kaplan, J. M. Facilitation of synaptic transmission by EGL-30 Gqα and EGL-8 PLCβ: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron 24, 335-346 (1999). (Pubitemid 29508408)
25. Tabuse, Y, Nishiwaki, K. & Miwa, J. Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans. Science 243, 1713-1716 (1989).
26. Fujiki, K., Mizuno, T., Hisamoto, N. & Matsumoto, K. The Caenorhabditis elegans Ste20 kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response. Mol. Cell. Biol. 30, 995-1003 (2010).
27. Mizuno, T., Fujiki, K., Sasakawa, A., Hisamoto, N. & Matsumoto, K. Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway Mol. Cell. Biol. 28, 7041-7049 (2008).
28. Calignano, A, La Rana, G., Giufrida, A. & Piomelli, D. Control of pain initiation by endogenous cannabinoids. Nature 394, 277-281 (1998). (Pubitemid 28335039)
29. Eljaschewitsch, E. et al. The endocannabinoid an and a mide protects neurons during CNS infammation by induction of MKP-1 in microglial cells. Neuron 49, 67-79 (2006). (Pubitemid 43017186)
30. van der Stelt, M. et al. Exogenous anandamide protects rat brain against acute neuronal injury in vivo. J. Neurosci. 15, 8765-8771 (2001). (Pubitemid 33054840)
31. Mechoulam, R., Spatz, M. & Shohami, E. Endocannabinoids and neuroprotection. Sci. STKE 129, re5 (2002).
32. Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974).
33. Jarho, P., Urtti, A., Pate, D. W., Suhonen, P. & Jarvinen, T. Increase in aqueous solubility, stability and in vitro corneal permeability of anandamide by hydroxypropyl-β-cyclodextrin. Int. J. Pharm. 137, 209-216 (1996). (Pubitemid 26226072)
34. Kawasaki, M. et al. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J. 18, 3604-3615 (1999). (Pubitemid 29308841)
35. Okochi, Y., Kimura, K. D., Ohta, A. & Mori, I. Diverse regulation of sensory signaling by C elegans nPKC-epsilon/eta TTX-4. EMBO J. 24, 2127-2137 (2005). (Pubitemid 40961797)
36. Arimoto, M. et al. The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31, 2216-2224 (2011).
37. Mello, C. C., Kramer, J. M., Stinchcomb, D. & Ambros, V. Efcient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970 (1991). (Pubitemid 21905425)