The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade

Nature Neuroscience

Volumn 15, Issue 4, 2012, Pages 551-557

  Li, Chun ^a   Hisamoto, Naoki ^a   Nix, Paola ^b   Kanao, Shuka ^a   Mizuno, Tomoaki ^a,c   Bastiani, Michael ^b   Matsumoto, Kunihiro ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN SVH 1; PROTEIN SVH 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HERMAPHRODITIC SPECIES; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MOLECULAR SEQUENCE DATA; NERVE REGENERATION;

EID: 84862810092     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3052     Document Type: Article

References (30)

1. Yanik, M.F. et al. Neurosurgery: functional regeneration after laser axotomy. Nature 432, 822 (2004).
2. Hammarlund, M., Jorgensen, E.M. & Bastiani, M.J. Axons break in animals lacking beta-spectrin. J. Cell Biol. 176, 269-275 (2007).
3. O'Brien, G.S. & Sagasti, A. Fragile axons forge the path to gene discovery: a MAP kinase pathway regulates axon regeneration. Sci. Signal. 2, e30 (2009).
4. Hammarlund, M., Nix, P., Hauth, L., Jorgensen, E.M. & Bastiani, M. Axon regeneration requires a conserved MAP kinase pathway. Science 323, 802-806 (2009).
5. Yan, D., Wu, Z., Chisholm, A.D. & Jin, Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell 138, 1005-1018 (2009).
6. Nix, P., Hisamoto, N., Matsumoto, K. & Bastiani, M. Axon regeneration requires co-activation of p38 and JNK MAPK pathways. Proc. Natl. Acad. Sci. USA 108, 10738-10743 (2011).
7. Camps, M., Nichols, A. & Arkinstall, S. Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 14, 6-16 (2000).
8. Mizuno, T. et al. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signalling pathway in stress response. EMBO J. 23, 2226-2234 (2004).
9. Donate, L.E. et al. Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGFI/MSP). Protein Sci. 3, 2378-2394 (1994).
10. Trusolino, L., Bertotti, A. & Comoglio, P.M. MET signalling: principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 11, 834-848 (2010).
11. Gaudino, G. et al. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J. 13, 3524-3532 (1994).
12. Hart, A.C., Sims, S. & Kaplan, J.M. Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Nature 378, 82-85 (1995).
13. McCarroll, S.A., Li, H. & Bargmann, C.I. Identification of transcriptional regulatory elements in chemosensory receptor genes by probabilistic segmentation. Curr. Biol. 15, 347-352 (2005).
14. Rodrigues, G.A. & Park, M. Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Mol. Cell Biol. 13, 6711-6722 (1993).
15. Santoro, M.M., Collesi, C., Grisendi, S., Gaudino, G. & Comoglio, P.M. Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol. Cell Biol. 16, 7072-7083 (1996).
16. Ferracini, R. et al. Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. J. Biol. Chem. 266, 19558-19564 (1991).
17. Knobel, K.M., Jorgensen, E.M. & Bastiani, M.J. Growth cones stall and collapse during axon outgrowth in Caenorhabditis elegans. Development 126, 4489-4498 (1999).
18. Nakata, K. et al. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell 120, 407-420 (2005).
19. Zhen, M., Huang, X., Bamber, B. & Jin, Y. Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron 26, 331-343 (2000).
20. Schaefer, A.M., Hadwiger, G.D. & Nonet, M.L. rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans. Neuron 26, 345-356 (2000).
21. Mizuno, T., Fujiki, K., Sasakawa, A., Hisamoto, N. & Matsumoto, K. Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signalling pathway. Mol. Cell Biol. 28, 7041-7049 (2008).
22. Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974).
23. Kamath, R.K., Martinez-Campos, M., Zipperlen, P., Fraser, A.G. & Ahringer, J. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in C. elegans. Genome Biol. 2, 1-10 (2001).
24. Fang-Yen, C., Gabel, C.V., Samuel, A.D., Bargmann, C.I. & Avery, J. Laser microsurgery in Caenorhabditis elegans. Methods Cell Biol. 107, 177-206 (2012).
25. Sakamoto, R. et al. The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol. Biol. Cell 16, 483-496 (2005).
26. Arimoto, M. et al. The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31, 2216-2224 (2011).
27. Colicelli, J. et al. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 88, 2913-2917 (1991).
28. Fujiki, K., Mizuno, T., Hisamoto, N. & Matsumoto, K. The Caenorhabditis elegans Ste20 kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signalling pathway mediating the stress response. Mol. Cell Biol. 30, 995-1003 (2010).
29. Mello, C.C., Kramer, J.M., Stinchcomb, D. & Ambros, V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970 (1991).
30. Bork, P., Doerks, T., Springer, T.A. & Snel, B. Domains in plexins: links to integrins and transcription factors. Trends Biochem. Sci. 24, 261-263 (1999).