The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis

Cell Cycle

Volumn 11, Issue 21, 2012, Pages 3972-3982

  Bonuccelli, Gloria ^a,b   Castello Cros, Remedios ^a,c   Capozza, Franco ^a   Martinez Outschoorn, Ubaldo E ^a,d   Lin, Zhao ^a   Tsirigos, Aristotelis ^e   Xuanmao, Jiao ^a   Whitaker Menezes, Diana ^a   Howell, Anthony ^f   Lisanti, Michael P ^a,d,f,g   Sotgia, Federica ^a,f,g  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c UNIVERSITY OF NAVARRA   (Spain)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e IBM T J WATSON RESEARCH CENTER   (United States)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Breast cancer; Cancer stem cells; Casein; Interferon signaling; Lactation; Metastasis; Milk proteins; STAT1

Indexed keywords

ALPHA CASEIN; CD44V ANTIGEN; MILK PROTEIN; STAT1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER PATIENT; CANCER STEM CELL; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; IMMUNOBLOTTING; LACTATION; METASTASIS; MOLECULAR MECHANICS; UPREGULATION;

EID: 84869397092     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.22227     Document Type: Article

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