Pain management in children: Part 2 - A transition from codeine to morphine for moderate to severe pain in children

Canadian Pharmacists Journal

Volumn 145, Issue 6, 2012, Pages 276-279

  Wong, Cecile ^a   Lau, Elaine ^a   Palozzi, Lori ^a   Campbell, Fiona ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMINOPHEN PLUS CODEINE; ANALGESIC AGENT; BUPIVACAINE; CODEINE; CYTOCHROME P450 2D6; FENTANYL; HYDROMORPHONE; IBUPROFEN; KETOROLAC; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; OXYCODONE; PARACETAMOL; PLACEBO; UNCLASSIFIED DRUG;

ANALGESIA; ARTICLE; CHILDHOOD DISEASE; CONSTIPATION; DRUG DEPENDENCE; DRUG EFFICACY; DRUG FATALITY; DRUG METABOLISM; DRUG MISUSE; DRUG SAFETY; DRUG TOXICITY; FEVER; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; NAUSEA; PAIN; POSTOPERATIVE PAIN; PRURITUS; RECOMMENDED DRUG DOSE; RESPIRATION DEPRESSION; SEDATION; SIDE EFFECT; SINGLE DRUG DOSE; URINE RETENTION; VOMITING;

EID: 84869385660     PISSN: 17151635     EISSN: 1913701X     Source Type: Journal    
DOI: 10.3821/145.6.cpj276     Document Type: Article

References (32)

1. Purcell-Jones G, Dormon F, Sumner E. The use of opioids in neonates. A retrospective study of 933 cases. Anaesthesia 1987;42:1316-20.
2. Reisime T, Pasternak G. Opioid analgesics and antago-nists. In: Hardman JG, Limbird LE, Mounoff PB, et al., editors. Goodman & Gilman's: the pharmacological basis of therapeutics. 9th ed. New York (NY): McGraw-Hill; 1996:521-55.
3. Brunton LL, Lazo JS, Parker KL, editors. Opioid analgesics: morphine and related opioid agonists. Goodman & Gilman's: the pharmacological basis of therapeutics. 11th ed. New York (NY): McGraw-Hill; 2006:563-8.
4. Clark E, Plint AC, Correll R, et al. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics 2007;119:460-7.
5. Charney RL, Yan Y, Schootman M, et al. Oxycodone versus codeine for triage in children with suspected forearm fracture: a randomized controlled trial. Pediatr Emerg Care 2008;24:595-600.
6. Eichelbaum M, Evert B. Influence of pharmacogenetics on drug disposition and response. Clin Exp Pharmacol Physiol 1996;23:983-5.
7. Lloyd-Thomas AR. Pain management in paediatric patients. Br J Anaesth 1990;64:85-104.
8. Gasche Y, Daali Y, Fathi M, et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med 2004;351:2827-31.
9. Crews KR, Gaedigk A, Dunnenberger HM, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther 2012;91:321-6.
10. Williams DG, Patel A, Howard RF. Pharmacogenetics of codeine metabolism in urban population of children and its implication for analgesic reliability. Br J Anaesth 2002;89:839-45.
11. Caraco Y, Sheller J, Wood AJ. Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. J Pharmacol Exp Ther 1999;290:413-22.
12. Williams DG, Hatch DJ, Howard RF. Codeine phosphate in paediatric medicine. Br J Anaesth 2001;86:413-21.
13. Ali S, Drendel AL, Kircher J, et al. Pain management of musculoskeletal injuries in children: current state and future directions. Pediatr Emerg Care 2010;26:518-28.
14. Health Canada. Advisories and warnings. Use of codeine products by nursing mothers. Available: www.hc-sc.gc.ca/ ahc-asc/media/advisories-avis/_2008/2008_164-eng.php (accessed October 8, 2008).
15. Madadi P, Koren G, Cairns J, et al. Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine. Can Fam Physician 2007;53:33-5.
16. Koren G, Cairns J, Chitayat D, et al. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeineprescribed mother. Lancet 2006;368:704.
17. Bouwmeester NJ, Hop WC, van Dijk M, et al. Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism. Intensive Care Med 2003;29:2009-15.
18. Ciszkowski C, Madadi P, Phillips MS, et al. Codeine, ultrarapid-metabolism genotype, and postoperative death. N Engl J Med 2009;361:827-8.
19. Kelly LE, Rieder M, van den Anker J, et al. More codeine fatalities after tonsillectomy in North American children. Pediatrics 2012;129:e1343-7.
20. Williams DG, Patel A, Howard RF. Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability. Br J Anaesth 2002;89:839-45.
21. Lynn AM, Nespeca MK, Opheim KE, Slattery JT. Respiratory effects of intravenous morphine infusions in neonates, infants and children after cardiac surgery. Anesth Analg 1993;77:695-701
22. Lynn AM, Nespeca MK, Bratton SL, et al. Intravenous morphine in postoperative infants: intermittent bolus dosing versus targeted continuous infusions. Pain 2000;88:95.
23. Duedahl TH, Hansen EH. A qualitative systematic review of morphine treatment in children with postoperative pain. Paediatr Anesth 2007;17:756-4.
24. Kart T, Christrup LL, Rasmussen M. Recommended use of morphine in neonates, infants and children based on literature review: part 2-clinical use. Paediatr Anaesth 1997;7:93-101.
25. Lynn AM, Nespeca MK, Opheim KE, et al. Respiratory effects of intravenous morphine infusion in neonates, infants, and children after cardiac surgery. Anesth Analg 1993;77:695-701.
26. Lynn AM, Opheim KE, Tyler DC. Morphine infusion after pediatric cardiac surgery. Crit Care Med 1984;12:863-6.
27. Krane EJ. Delayed respiratory depression in a child after caudal epidural morphine. Anesth Analg 1988;67:79-82.
28. Blackman RG, Reynolds J, Shively J. Intrathecal morphine: dosage and efficacy in younger patients for control of postoperative pain following spinal fusion. Orthopedics 1991;14:555-7.
29. Campbell F, Palozzi L, Jeavons M, Marcuz J, et al. Pain management. In: Brown S, Daneman D, Dodds A, et al, editors. Policies & Procedure Database. Clinical Practice Guideline. Toronto (ON): The Hospital for Sick Children; 2008.
30. Kart T, Christrup LL, Rasmussen M. Recommended use of morphine in neonates, infants and children based on literature review: part 1-pharmacokinetics. Paediatr Anaesth 1997;7:5-11.
31. Twycross R, Wilcock A, Charlesworth S, et al. Palliative care formulary. 3rd ed. Oxford: Radcliffe Medical Press; 2007.
32. American Academy of Pediatrics. Committee on Psychosocial Aspects of Child and Family Health; Task Force on Pain in Infants, Children, and Adolescents. The assessment and management of acute pain in infants, children, and adolescents. Pediatrics 2001;108:793-7.