A robust process for an mGluR5 negative allosteric modulator: Difluoromethylation and sonogashira coupling on large scale

Organic Process Research and Development

Volumn 16, Issue 11, 2012, Pages 1854-1860

  Sperry, Jeffrey B ^a,b   Farr, Roger M ^a   Levent, Mahmut ^a   Ghosh, Mousumi ^a   Hoagland, Steven M ^a   Varsolona, Richard J ^a   Sutherland, Karen ^a  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; CRYSTALLINE MORPHOLOGIES; HIGH TEMPERATURE; KEY FEATURE; NON-POLAR; SONOGASHIRA COUPLING; WATER-MISCIBLE SOLVENTS;

CHEMICAL REACTIONS;

REACTION INTERMEDIATES;

EID: 84869381193     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op3002728     Document Type: Article

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