The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis

American Journal of Respiratory and Critical Care Medicine

Volumn 186, Issue 10, 2012, Pages 999-1007

  Coughlan, Catherine A ^a   Chotirmall, Sanjay H ^a   Renwick, Julie ^b   Hassan, Tidi ^a   Low, Teck Boon ^a   Bergsson, Gudmundur ^a   Eshwika, Ahmed ^c   Bennett, Kathleen ^d   Dunne, Katie ^b   Greene, Catherine M ^a   Gunaratnam, Cedric ^a   Kavanagh, Kevin ^c   Logan, Patrick M ^e   Murphy, Philip ^b   Reeves, Emer P ^a   McElvaney, Noel G ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b ADELAIDE AND MEATH HOSPITAL   (Ireland)

^c Medical Mycology Unit   (Ireland)

^d ST JAMES S HOSPITAL   (Ireland)

^e BEAUMONT HOSPITAL   (Ireland)

Author keywords

Aspergillus fumigatus; Cystic fibrosis; Inflammation; Itraconazole; Vitamin D receptor

Indexed keywords

CALCITRIOL; GLIOTOXIN; INTERLEUKIN 13; INTERLEUKIN 5; ITRACONAZOLE; VITAMIN D RECEPTOR;

ADULT; ANTIMICROBIAL THERAPY; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ASPERGILLOSIS; LUNG FUNCTION; LUNG FUNCTION TEST; LUNG LAVAGE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; BLOTTING, WESTERN; BRONCHI; CELLS, CULTURED; CYSTIC FIBROSIS; DOWN-REGULATION; EPITHELIUM; FEMALE; GLIOTOXIN; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-13; INTERLEUKIN-5; ITRACONAZOLE; MALE; PULMONARY ASPERGILLOSIS; RECEPTORS, CALCITRIOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH2 CELLS; TRACHEA; YOUNG ADULT;

EID: 84869214356     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201203-0478OC     Document Type: Article

References (38)

1. Amin R, Dupuis A, Aaron SD, Ratjen F. The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis. Chest 2010;137:171-176.
2. Chotirmall SH, Greene CM, McElvaney NG. Candida species in cystic fibrosis: a road less travelled. Med Mycol 2010;48:S114-S124.
3. Chotirmall SH, O'Donoghue E, Bennett K, Gunaratnam C, O'Neill SJ, McElvaney NG. Sputum Candida albicans presages FEV1 decline and hospital-treated exacerbations in cystic fibrosis. Chest 2010;138: 1186-1195.
4. Horré R, Symoens F, Delhaes L, Bouchara JP. Fungal respiratory infections in cystic fibrosis: a growing problem. Med Mycol 2010;48: S1-S3.
5. Sudfeld CR, Dasenbrook EC, Merz WG, Carroll KC, Boyle MP. Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis. J Cyst Fibros 2010;9:110-116.
6. Chotirmall SH, Branagan P, Gunaratnam C, McElvaney NG. Aspergillus/allergic bronchopulmonary aspergillosis in an Irish cystic fibrosis population: a diagnostically challenging entity. Respir Care 2008;53:1035-1041.
7. Paugam A, Baixench MT, Demazes-Dufeu N, Burgel PR, Sauter E, Kanaan R, Dusser D, Dupouy-Camet J, Hubert D. Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France. Med Mycol 2010;48:S32-S36.
8. Allard JB, Poynter ME, Marr KA, Cohn L, Rincon M, Whittaker LA. Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator. J Immunol 2006;177:5186-5194. (Pubitemid 44527591)
9. Kreindler JL, Steele C, Nguyen N, Chan YR, Pilewski JM, Alcorn JF, Vyas YM, Aujla SJ, Finelli P, Blanchard M, et al. Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Clin Invest 2010;120:3242-3254.
10. Wittke A, Weaver V, Mahon BD, August A, Cantorna MT. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol 2004;173:3432-3436. (Pubitemid 39142054)
11. Sundar IK, Hwang JW, Wu S, Sun J, Rahman I. Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. Biochem Biophys Res Commun 2011;406:127-133.
12. McMahon MA, Chotirmall SH, McCullagh B, Branagan P, McElvaney NG, Logan PM. Radiological abnormalities associated with Aspergillus colonization in a cystic fibrosis population. Eur J Radiol 2012;81: e197-e202.
13. de Vrankrijker AM, van der Ent CK, van Berkhout FT, Stellato RK, Willems RJ, Bonten MJ, Wolfs TF. Aspergillus fumigatus colonization in cystic fibrosis: Implications for lung function? Clin Microbiol Infect 2011;17:1381-1386.
14. Coughlan CA, Reeves EP, Bergsson G, Greene CM, Kavanagh K, O'Neill SJ, McElvaney NG. Elevated gliotoxin production by Aspergillus fumigatus down regulates vitamin D receptor expression in cystic fibrosis airways. Am J Respir Crit Care Med 2011;183:A5733.
15. Coughlan CA, Reeves EP, Bergsson G, Greene CM, O'Neill SJ, McElvaney NG. Down regulation of the 1a, 25 dihydroxyvitamin-d3 (vitamin D3) receptor by Aspergillus fumigatus secreted gliotoxin in cystic fibrosis [abstract]. Am J Respir Crit Care Med 2010;181:A6184.
16. Coughlan CA, Chotirmall SH, Renwick J, Hassan T, Low TB, Bergsson G, Bennett K, Eshwika A, Dunne K, Greene CM, et al. Itraconazole up-regulates the vitamin D receptor and reduces T-helper 2 responses in Aspergillus fumigatus colonized with cystic fibrosis. Am J Respir Crit Care Med 2012;185:A2807.
17. Stevens DA, Moss RB, Kurup VP, Knutsen AP, Greenberger P, Judson MA, Denning DW, Crameri R, Brody AS, Light M, et al. Allergic bronchopulmonary aspergillosis in cystic fibrosis-state of the art: Cystic Fibrosis Foundation Consensus Conference. Clin Infect Dis 2003;37:S225-S264. (Pubitemid 37260463)
18. Chotirmall SH, Greene CM, Oglesby IK, Thomas W, O'Neill SJ, Harvey BJ, McElvaney NG. 17beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor. Am J Respir Crit Care Med 2010;182:62-72.
19. Vega-Carrascal I, Reeves EP, Niki T, Arikawa T, McNally P, O'Neill SJ, Hirashima M, McElvaney NG. Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. J Immunol 2011;186:2897-2909.
20. Cystic Fibrosis Trust. Laboratory standards for processing microbiological samples from people with cystic fibrosis. Kent, UK: Cystic Fibrosis Trust; 2010;
21. Hartl D, Griese M, Kappler M, Zissel G, Reinhardt D, Rebhan C, Schendel DJ, Krauss-Etschmann S. Pulmonary T(h)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. J Allergy Clin Immunol 2006;117:204-211. (Pubitemid 43017162)
22. Amitani R, Taylor G, Elezis EN, Llewellyn-Jones C, Mitchell J, Kuze F, Cole PJ, Wilson R. Purification and characterization of factors produced by Aspergillus fumigatus which affect human ciliated respiratory epithelium. Infect Immun 1995;63:3266-3271.
23. Gibson PG. Allergic bronchopulmonary aspergillosis. Semin Respir Crit Care Med 2006;27:185-191.
24. Knutsen AP, Slavin RG. Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. Clin Dev Immunol 2011;2011:843763.
25. Moss RB. Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Med Mycol 2005;43:S203-S206. (Pubitemid 41038571)
26. Gilbert CR, Arum SM, Smith CM. Vitamin D deficiency and chronic lung disease. Can Respir J 2009;16:75-80.
27. McNally P, Coughlan C, Bergsson G, Doyle M, Taggart C, Adorini L, Uskokovic MR, El-Nazir B, Murphy P, Greally P, et al. Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis. J Cyst Fibros 2011;10:428-434.
28. Hall WB, Sparks AA, Aris RM. Vitamin D deficiency in cystic fibrosis. Int J Endocrinol 2010;2010:218691.
29. Dubucquoi S, Desreumaux P, Janin A, Klein O, Goldman M, Tavernier J, Capron A, Capron M. Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion. J Exp Med 1994;179:703-708. (Pubitemid 24058758)
30. Wynn TA. IL-13 effector functions. Annu Rev Immunol 2003;21:425-456. (Pubitemid 37174537)
31. Gardiner DM, Waring P, Howlett BJ. The epipolythiodioxopiperazine (etp) class of fungal toxins: distribution, mode of action, functions and biosynthesis. Microbiology 2005;151:1021-1032. (Pubitemid 40568000)
32. Tronchin G, Bouchara JP, Larcher G, Lissitzky JC, Chabasse D. Interaction between Aspergillus fumigatus and basement membrane laminin: binding and substrate degradation. Biol Cell 1993;77:201-208. (Pubitemid 23196854)
33. Lewis RE, Wiederhold NP, Chi J, Han XY, Komanduri KV, Kontoyiannis DP, Prince RA. Detection of gliotoxin in experimental and human aspergillosis. Infect Immun 2005;73:635-637. (Pubitemid 40041162)
34. Aaron SD, Vandemheen KL, Freitag A, Pedder L, Cameron W, Lavoie A, Paterson N, Wilcox P, Rabin H, Tullis E, et al. Treatment of Aspergillus fumigatus in patients with cystic fibrosis: a randomized, placebo-controlled pilot study. PLoS ONE 2012;7:e36077.
35. Baxter CG, Jones AM, Webb K, Denning DW. Homogenisation of cystic fibrosis sputum by sonication: an essential step for Aspergillus PCR. J Microbiol Methods 2011;85:75-81.
36. Denning DW, Venkateswarlu K, Oakley KL, Anderson MJ, Manning NJ, Stevens DA, Warnock DW, Kelly SL. Itraconazole resistance in Aspergillus fumigatus. Antimicrob Agents Chemother 1997;41:1364-1368. (Pubitemid 27231443)
37. Mortensen KL, Jensen RH, Johansen HK, Skov M, Pressler T, Howard SJ, Leatherbarrow H, Mellado E, Arendrup MC. Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance. J Clin Microbiol 2011;49:2243-2251.
38. Fuchs HJ, Borowitz DS, Christiansen DH, Morris EM, Nash ML, Ramsey BW, Rosenstein BJ, Smith AL, Wohl ME. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The pulmozyme study group. N Engl J Med 1994;331:637-642. (Pubitemid 24276863)