The Analgesic Concentration of Oxycodone with Co-administration of Paracetamol - A Dose-Finding Study in Adult Patients Undergoing Laparoscopic Cholecystectomy

Basic and Clinical Pharmacology and Toxicology

Volumn 111, Issue 6, 2012, Pages 391-395

  Kokki, Merja ^a,b   Broms, Susanna ^a,b   Eskelinen, Matti ^a,b   Neuvonen, Pertti J ^c   Halonen, Toivo ^d   Kokki, Hannu ^a,b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d Eastern Finland University   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

OXYCODONE; OXYMORPHONE; PARACETAMOL;

ADULT; ANALGESIA; ARTICLE; BLOOD ANALYSIS; CHOLECYSTECTOMY; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFICACY; FEMALE; HUMAN; LAPAROSCOPIC SURGERY; MALE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURGICAL WOUND;

ACETAMINOPHEN; ADULT; AGED; ANALGESICS; CHOLECYSTECTOMY, LAPAROSCOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; OXYCODONE; PAIN MANAGEMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES;

EID: 84869199460     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2012.00916.x     Document Type: Article

References (14)

1. Salonen A, Silvola J, Kokki H Does 1 or 2 g paracetamol added to ketoprofen enhance analgesia in adult tonsillectomy patients? Acta Anaesthesiol Scand 2009;53:1200-6.
2. Lahtinen P, Kokki H, Hendolin H, Hakala T, Hynynen M Propacetamol as adjunctive treatment for postoperative pain after cardiac surgery. Anesth Analg 2002;95:813-9.
3. Bisgaard T, Klarskov B, Rosenberg J, Kehlet H Characteristics and prediction of early pain after laparoscopic cholecystectomy. Pain 2001;90:261-9.
4. Ekstein P, Szold A, Sagie B, Werbin N, Klausner JM, Weinbroum AA Laparoscopic surgery may be associated with severe pain and high analgesia requirements in the immediate post-operative period. Ann Surg 2006;243:41-6.
5. Gourlay GK, Kowalski SR, Plummer JL, Cousins MJ, Armstrong PJ Fentanyl blood concentration-analgesic response relationship in the treatment of postoperative pain. Anesth Analg 1988;67:329-37.
6. Camu F, Vanlersberghe C Pharmacology of systemic analgesics. Best Pract Res Clin Anaesthesiol 2002;16:475-88.
7. Kokki M, Broms S, Eskelinen M, Rasanen I, Ojanperä I, Kokki H Analgesic concentrations of oxycodone - a prospective clinical pk/pd study in patients with laparoscopic cholecystectomy. Basic Clin Pharmacol Toxicol 2012;110:469-75.
8. Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002;166:1338-44.
9. Neuvonen M, Neuvonen PJ Determination of oxycodone, noroxycodone, oxymorphone, and noroxymorphone in human plasma by liquid chromatography-electrospray-tandem mass spectrometry. Ther Drug Monit 2008;30:333-40.
10. Kumpulainen E, Kokki H, Halonen T, Heikkinen M, Savolainen J, Laisalmi M Paracetamol (acetaminophen) penetrates readily into the cerebrospinal fluid of children after intravenous administration. Pediatrics 2007;119:766-71.
11. Piguet V, Desmeules J, Dayer P Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex. Eur J Clin Pharmacol 1998;53:321-4.
12. Salihoglu Z, Yildirim M, Demiroluk S, Kaya G, Karatas A, Ertem M et al. Evaluation of intravenous paracetamol administration on postoperative pain and recovery characteristics in patients undergoing laparoscopic cholecystectomy. Surg Laparosc Endosc Percutan Tech 2009;19:321-3.
13. Gaskell H, Derry S, Moore RA, McQuay HJ Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. Cochrane Database Syst Rev 2009;8:CD002763.
14. Kemppainen T, Kokki H, Tuomilehto H, Seppä J, Nuutinen J Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery. Laryngoscope 2006;116:2125-8.