Switching the stereochemical outcome of 6- endo - Trig cyclizations; Synthesis of 2,6- cis -6-substituted 4-oxopipecolic acids

Journal of Organic Chemistry

Volumn 77, Issue 22, 2012, Pages 10001-10009

  Daly, Mark ^a   Cant, Alastair A ^a   Fowler, Lindsay S ^a   Simpson, Graham L ^b   Senn, Hans Martin ^a   Sutherland, Andrew ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6-ENDO-TRIG; CYCLIZATIONS; DEPROTECTION; DIRECT SYNTHESIS; DRIVING FORCES; ENOLATE INTERMEDIATES; EQUILIBRIUM PROCESS; PRODUCT FORMATION; SIDE-CHAINS; STEREOSELECTIVE REDUCTION; TARGET COMPOUND; TAUTOMERIZATIONS;

AMINO ACIDS; OLEFINS;

CYCLIZATION;

2,6 CIS 6 SUBSTITUTED 4 OXOPIPECOLIC ACID DERIVATIVE; PIPECOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG SYNTHESIS; MOLECULAR MODEL; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; TAUTOMERIZATION;

CYCLIZATION; MOLECULAR STRUCTURE; PIPECOLIC ACIDS; STEREOISOMERISM;

EID: 84869193057     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo3022583     Document Type: Article

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