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Volumn 5, Issue 5, 2012, Pages 533-545

Sequential or combination therapy for multiple myeloma

Author keywords

bortezomib; combination therapy; cytotoxic therapies; lenalidomide; myeloma; novel agents; sequential therapy; thalidomide

Indexed keywords

6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; BORTEZOMIB; CARFILZOMIB; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DELANZOMIB; DEXAMETHASONE; ELOTUZUMAB; IMMUNOMODULATING AGENT; IXAZOMIB; IXAZOMIB CITRATE; LENALIDOMIDE; MELPHALAN; OPROZOMIB; PANOBINOSTAT; PREDNISONE; PROTEASOME INHIBITOR; SALINOSPORAMIDE A; TANESPIMYCIN; THALIDOMIDE; VORINOSTAT;

EID: 84869177971     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/ehm.12.49     Document Type: Review
Times cited : (5)

References (110)
  • 2
    • 84870735803 scopus 로고    scopus 로고
    • Sequence of therapy in multiple myeloma: Does it matter? Retrospective evaluation of patients with multiple myeloma who have received bortezomib followed by lenalidomide or vice versa
    • Patel AM, Ho VQ, Shain KH et al. Sequence of therapy in multiple myeloma: does it matter? Retrospective evaluation of patients with multiple myeloma who have received bortezomib followed by lenalidomide or vice versa. ASH Annual Meeting Abstracts 118(21), 3979 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3979
    • Patel, A.M.1    Ho, V.Q.2    Shain, K.H.3
  • 3
    • 84870734426 scopus 로고    scopus 로고
    • The improved efficacy of bortezomib containing induction regimens (BCIR versus non-bortezomib containing induction regimens (NBCIR) in transplant-eligible patients with multiple myeloma (MM): Meta-analysis of Phase III randomized controlled trials (RCTs)
    • Nooka AK, Kaufman JL, Behera M et al. The improved efficacy of bortezomib containing induction regimens (BCIR) versus non-bortezomib containing induction regimens (NBCIR) in transplant-eligible patients with multiple myeloma (MM): meta-analysis of Phase III randomized controlled trials (RCTs). ASH Annual Meeting Abstracts 118(21), 3994 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3994
    • Nooka, A.K.1    Kaufman, J.L.2    Behera, M.3
  • 4
    • 58249097191 scopus 로고    scopus 로고
    • Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma
    • Kyle RA, Rajkumar SV. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia 23(1), 3-9 (2009).
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 3-9
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 5
    • 59449099316 scopus 로고    scopus 로고
    • Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation
    • GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Groups.
    • Paiva B, Vidriales MB, Cerveró J et al.; GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Groups. Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation. Blood 112(10), 4017-4023 (2008).
    • (2008) Blood , vol.112 , Issue.10 , pp. 4017-4023
    • Paiva, B.1    Vidriales, M.B.2    Cerveró, J.3
  • 6
    • 40849151008 scopus 로고    scopus 로고
    • Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders
    • European Myeloma Network.
    • Rawstron AC, Orfao A, Beksac M et al.; European Myeloma Network. Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders. Haematologica 93(3), 431-438 (2008).
    • (2008) Haematologica , vol.93 , Issue.3 , pp. 431-438
    • Rawstron, A.C.1    Orfao, A.2    Beksac, M.3
  • 7
    • 0035103579 scopus 로고    scopus 로고
    • The impact of attaining a minimal disease state after high-dose melphalan and autologous transplantation for multiple myeloma
    • Davies FE, Forsyth PD, Rawstron AC et al. The impact of attaining a minimal disease state after high-dose melphalan and autologous transplantation for multiple myeloma. Br. J. Haematol. 112(3), 814-819 (2001).
    • (2001) Br. J. Haematol. , vol.112 , Issue.3 , pp. 814-819
    • Davies, F.E.1    Forsyth, P.D.2    Rawstron, A.C.3
  • 8
    • 77951625298 scopus 로고    scopus 로고
    • Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma
    • Ladetto M, Pagliano G, Ferrero S et al. Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma. J. Clin. Oncol. 28(12), 2077-2084 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.12 , pp. 2077-2084
    • Ladetto, M.1    Pagliano, G.2    Ferrero, S.3
  • 9
    • 31544436323 scopus 로고    scopus 로고
    • Antimyeloma activity of heat shock protein 90 inhibition
    • Mitsiades CS, Mitsiades NS, McMullan CJ et al. Antimyeloma activity of heat shock protein 90 inhibition. Blood 107(3), 1092-1100 (2006).
    • (2006) Blood , vol.107 , Issue.3 , pp. 1092-1100
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 10
    • 79957539428 scopus 로고    scopus 로고
    • Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: Results of a Phase 1/2 study
    • Richardson PG, Chanan-Khan AA, Lonial S et al. Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a Phase 1/2 study. Br. J. Haematol. 153(6), 729-740 (2011).
    • (2011) Br. J. Haematol. , vol.153 , Issue.6 , pp. 729-740
    • Richardson, P.G.1    Chanan-Khan, A.A.2    Lonial, S.3
  • 11
    • 34249650184 scopus 로고    scopus 로고
    • Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: Therapeutic implications
    • Spisek R, Charalambous A, Mazumder A, Vesole DH, Jagannath S, Dhodapkar MV. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: Therapeutic implications. Blood 109(11), 4839-4845 (2007).
    • (2007) Blood , vol.109 , Issue.11 , pp. 4839-4845
    • Spisek, R.1    Charalambous, A.2    Mazumder, A.3    Vesole, D.H.4    Jagannath, .S.5    Dhodapkar, M.V.6
  • 12
    • 34250162144 scopus 로고    scopus 로고
    • Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells
    • Xu W, Neckers L. Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells. Clin. Cancer Res. 13(6), 1625-1629 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.6 , pp. 1625-1629
    • Xu, W.1    Neckers, L.2
  • 13
    • 36148976786 scopus 로고    scopus 로고
    • Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells
    • Neckers L, Kern A, Tsutsumi S. Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells. Chem. Biol. 14(11), 1204-1206 (2007).
    • (2007) Chem. Biol. , vol.14 , Issue.11 , pp. 1204-1206
    • Neckers, L.1    Kern, A.2    Tsutsumi, S.3
  • 14
    • 35148813851 scopus 로고    scopus 로고
    • Heat shock protein 90: A potential therapeutic target in leukemic progenitor and stem cells harboring mutant BCR-ABL resistant to kinase inhibitors
    • Peng C, Li D, Li S. Heat shock protein 90: A potential therapeutic target in leukemic progenitor and stem cells harboring mutant BCR-ABL resistant to kinase inhibitors. Cell Cycle 6(18), 2227-2231 (2007).
    • (2007) Cell Cycle , vol.6 , Issue.18 , pp. 2227-2231
    • Peng, C.1    Li, D.2    Li, S.3
  • 15
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • Catley L, Weisberg E, Kiziltepe T et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 108(10), 3441-3449 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3441-3449
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3
  • 16
    • 20844435806 scopus 로고    scopus 로고
    • Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
    • Hideshima T, Bradner JE, Wong J et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc. Natl Acad. Sci. U.S.A. 102(24), 8567-8572 (2005).
    • (2005) Proc. Natl Acad. Sci. U.S.A. , vol.102 , Issue.24 , pp. 8567-8572
    • Hideshima, T.1    Bradner, J.E.2    Wong, J.3
  • 17
    • 77955871803 scopus 로고    scopus 로고
    • Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma
    • Kikuchi J, Wada T, Shimizu R et al. Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma. Blood 116(3), 406-417 (2010).
    • (2010) Blood , vol.116 , Issue.3 , pp. 406-417
    • Kikuchi, J.1    Wada, T.2    Shimizu, R.3
  • 18
    • 78650041246 scopus 로고    scopus 로고
    • Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes
    • David E, Kaufman JL, Flowers CR et al. Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes. Blood 116(24), 5285-5288 (2010).
    • (2010) Blood , vol.116 , Issue.24 , pp. 5285-5288
    • David, E.1    Kaufman, J.L.2    Flowers, C.R.3
  • 19
    • 79953656326 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors, autophagy, and proteasome inhibition: Synergy for all the right reasons
    • Lonial S, Boise LH. Farnesyl transferase inhibitors, autophagy, and proteasome inhibition: synergy for all the right reasons. Autophagy 7(4), 448-449 (2011).
    • (2011) Autophagy , vol.7 , Issue.4 , pp. 448-449
    • Lonial, S.1    Boise, L.H.2
  • 20
    • 84870759737 scopus 로고    scopus 로고
    • Selective HDAC6 inhibition via ACY-1215, either alone or in combination with bortezomib, restores osteoblast function and suppresses osteoclast differentiation in multiple myeloma
    • Santo L, Hideshima T, Kung AL et al. Selective HDAC6 inhibition via ACY-1215, either alone or in combination with bortezomib, restores osteoblast function and suppresses osteoclast differentiation in multiple myeloma. ASH Annual Meeting Abstracts 118(21), 2908 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 2908
    • Santo, L.1    Hideshima, T.2    Kung, A.L.3
  • 21
    • 69349097803 scopus 로고    scopus 로고
    • Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma
    • Badros A, Burger AM, Philip S et al. Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma. Clin. Cancer Res. 15(16), 5250-5257 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.16 , pp. 5250-5257
    • Badros, A.1    Burger, A.M.2    Philip, S.3
  • 22
    • 51049121251 scopus 로고    scopus 로고
    • Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA in combination with bortezomib in patients with advanced multiple myeloma
    • Weber DM, Jagannath S, Mazumder A et al in combination with bortezomib in patients with advanced multiple myeloma. ASH Annual Meeting Abstracts 110(11), 1172 (2007).
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 1172
    • Weber, D.M.1    Jagannath, S.2    Mazumder, A.3
  • 23
    • 84870734616 scopus 로고    scopus 로고
    • High rate of durable responses in a phase I/II trial of the histone deacetylase inhibitor romidepsin combined with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma
    • Harrison S, Quach H, Link E et al. High rate of durable responses in a phase I/II trial of the histone deacetylase inhibitor romidepsin combined with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma. Haematologica 96(Suppl 1), 233 (2011).
    • (2011) Haematologica , vol.96 , Issue.SUPPL. 1 , pp. 233
    • Harrison, S.1    Quach, H.2    Link, E.3
  • 24
    • 84861804180 scopus 로고    scopus 로고
    • Vantage 095: Vorinostat in combination with bortezomib in salvage multiple myeloma patients: Final study results of a global Phase 2b trial
    • Siegel DS, Dimopoulos MA, Yoon S-S et al. Vantage 095: vorinostat in combination with bortezomib in salvage multiple myeloma patients: final study results of a global Phase 2b trial. ASH Annual Meeting Abstracts 118(21), 480 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 480
    • Siegel, D.S.1    Dimopoulos, M.A.2    Yoon, S.-S.3
  • 25
    • 84859719940 scopus 로고    scopus 로고
    • Vantage 088: Vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: Results of a global, randomized Phase 3 trial
    • Dimopoulos MA, Jagannath S, Yoon S-S et al. Vantage 088: vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: results of a global, randomized Phase 3 trial. ASH Annual Meeting Abstracts 118(21), 811 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 811
    • Dimopoulos, M.A.1    Jagannath, S.2    Yoon, S.-S.3
  • 26
    • 0037973279 scopus 로고    scopus 로고
    • A Phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J et al. A Phase 2 study of bortezomib in relapsed, refractory myeloma. N. Engl. J. Med. 348(26), 2609-2617 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , Issue.26 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 27
    • 20444433230 scopus 로고    scopus 로고
    • Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • Richardson PG, Sonneveld P, Schuster MW et al. Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N. Engl. J. Med. 352(24), 2487-2498 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , Issue.24 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 28
    • 34548539381 scopus 로고    scopus 로고
    • Randomized Phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression
    • Orlowski RZ, Nagler A, Sonneveld P et al. Randomized Phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J. Clin. Oncol. 25(25), 3892-3901 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.25 , pp. 3892-3901
    • Orlowski, R.Z.1    Nagler, A.2    Sonneveld, P.3
  • 29
    • 84864055971 scopus 로고    scopus 로고
    • Superiority of the triple combination of bortezomib-thalidomide- dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: The MMVAR/IFM 2005- 04 randomized Phase III trial from the chronic leukemia working party of the European group for blood and marrow transplantation
    • Garderet L, Iacobelli S, Moreau P et al. Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: The MMVAR/IFM 2005-04 randomized Phase III trial from the chronic leukemia working party of the European group for blood and marrow transplantation. J. Clin. Oncol. 30(20), 2475-2482 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.20 , pp. 2475-2482
    • Garderet, L.1    Iacobelli, S.2    Moreau, P.3
  • 30
    • 84864069892 scopus 로고    scopus 로고
    • The era of combination therapy in myeloma
    • Lonial S, Kaufman JL. The era of combination therapy in myeloma. J. Clin. Oncol. 30(20), 2434-2436 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.20 , pp. 2434-2436
    • Lonial, S.1    Kaufman, J.L.2
  • 31
    • 84859724793 scopus 로고    scopus 로고
    • Vorinostat in combination with pegylated liposomal doxorubicin (PLD) and bortezomib (B) in patients with relapsed/refractory multiple myeloma (R/R MM): Final results of a Phase I study
    • Voorhees PM, Gasparetto C, Osman K et al. Vorinostat in combination with pegylated liposomal doxorubicin (PLD) and bortezomib (B) in patients with relapsed/refractory multiple myeloma (R/R MM): final results of a Phase I study. ASH Annual Meeting Abstracts 118(21), 3985 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3985
    • Voorhees, P.M.1    Gasparetto, C.2    Osman, K.3
  • 32
    • 84891597843 scopus 로고    scopus 로고
    • A Phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma
    • Suppl. Abstract
    • San-Miguel J, Richardson P, Sezer O et al. A Phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma. J. Clin. Oncol. 29(Suppl.), Abstract 8075 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 8075
    • San-Miguel, J.1    Richardson, P.2    Sezer, O.3
  • 33
    • 84870761127 scopus 로고    scopus 로고
    • Phase Ib dose-escalation study of oral panobinostat and IV bortezomib in patients with relapsed or relapsed and refractory multiple myeloma: Updated results
    • San-Miguel J, Sezer O, Guenther A et al. Phase Ib dose-escalation study of oral panobinostat and IV bortezomib in patients with relapsed or relapsed and refractory multiple myeloma: updated results. Hematologica 96(Suppl 1), 238 (2011).
    • (2011) Hematologica , vol.96 , Issue.238 SUPPL. 1
    • San-Miguel, J.1    Sezer, O.2    Guenther, A.3
  • 34
    • 84859704721 scopus 로고    scopus 로고
    • Phase II study of the pan-deacetylase inhibitor panobinostat in combination with bortezomib and dexamethasone in relapsed and bortezomib-refractory multiple myeloma (PANORAMA 2)
    • Richardson PG, Alsina M, Weber DM et al. Phase II study of the pan-deacetylase inhibitor panobinostat in combination with bortezomib and dexamethasone in relapsed and bortezomib-refractory multiple myeloma (PANORAMA 2). ASH Annual Meeting Abstracts 118(21), 814 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 814
    • Richardson, P.G.1    Alsina, M.2    Weber, D.M.3
  • 35
    • 33747872306 scopus 로고    scopus 로고
    • A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
    • Baughn LB, Di Liberto M, Wu K et al. A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6. Cancer Res. 66(15), 7661-7667 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.15 , pp. 7661-7667
    • Baughn, L.B.1    Di Liberto, M.2    Wu, K.3
  • 36
    • 48649105786 scopus 로고    scopus 로고
    • A novel therapeutic combination using PD 0332991 and bortezomib: Study in the 5T33MM myeloma model
    • Menu E, Garcia J, Huang X et al. A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model. Cancer Res. 68(14), 5519-5523 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.14 , pp. 5519-5523
    • Menu, E.1    Garcia, J.2    Huang, X.3
  • 37
    • 84870733506 scopus 로고    scopus 로고
    • A Phase I trial of PD 0332991, a novel, orally-bioavailable CDK4/6-specific inhibitor administered in combination with bortezomib and dexamethasone to patients with relapsed and refractory multiple myeloma
    • Niesvizky R, Ely S, Jayabalan DS et al. A Phase I trial of PD 0332991, a novel, orally-bioavailable CDK4/6-specific inhibitor administered in combination with bortezomib and dexamethasone to patients with relapsed and refractory multiple myeloma. ASH Annual Meeting Abstracts 114(22), 1877 (2009).
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 1877
    • Niesvizky, R.1    Ely, S.2    Jayabalan, D.S.3
  • 38
    • 50449086728 scopus 로고    scopus 로고
    • VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK et al.; VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N. Engl. J. Med. 359(9), 906-917 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.9 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 39
    • 84858791957 scopus 로고    scopus 로고
    • Continued overall survival benefit after 5 years' follow-up with bortezomib-melphalan-prednisone (VMP) versus melphalan-prednisone (MP) in patients with previously untreated multiple myeloma, and no increased risk of second primary malignancies: Final results of the Phase 3 VISTA trial
    • Miguel JFS, Schlag R, Khuageva NK et al. Continued overall survival benefit after 5 years' follow-up with bortezomib-melphalan-prednisone (VMP) versus melphalan-prednisone (MP) in patients with previously untreated multiple myeloma, and no increased risk of second primary malignancies: final results of the Phase 3 VISTA trial. ASH Annual Meeting Abstracts 118(21), 476 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 476
    • Miguel, J.F.S.1    Schlag, R.2    Khuageva, N.K.3
  • 40
    • 78650993336 scopus 로고    scopus 로고
    • Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: A randomized controlled trial
    • Palumbo A, Bringhen S, Rossi D et al. Bortezomib-melphalan-prednisone- thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: A randomized controlled trial. J. Clin. Oncol. 28(34), 5101-5109 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.34 , pp. 5101-5109
    • Palumbo, A.1    Bringhen, S.2    Rossi, D.3
  • 41
    • 61849152933 scopus 로고    scopus 로고
    • Many facets of bortezomib resistance/susceptibility
    • Kumar S, Rajkumar SV. Many facets of bortezomib resistance/ susceptibility. Blood 112(6), 2177-2178 (2008).
    • (2008) Blood , vol.112 , Issue.6 , pp. 2177-2178
    • Kumar, S.1    Rajkumar, S.V.2
  • 42
    • 77950238258 scopus 로고    scopus 로고
    • Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
    • Kupperman E, Lee EC, Cao Y et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 70(5), 1970-1980 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.5 , pp. 1970-1980
    • Kupperman, E.1    Lee, E.C.2    Cao, Y.3
  • 43
    • 84862644984 scopus 로고    scopus 로고
    • Investigational agent MLN9708, an oral proteasome inhibitor, in patients (Pts) with relapsed and/or refractory multiple myeloma (MM): Results from the expansion cohorts of a Phase 1 dose-escalation study
    • Richardson PG, Baz R, Wang L et al. Investigational agent MLN9708, an oral proteasome inhibitor, in patients (Pts) with relapsed and/or refractory multiple myeloma (MM): results from the expansion cohorts of a Phase 1 dose-escalation study. ASH Annual Meeting Abstracts 118(21), 301 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 301
    • Richardson, P.G.1    Baz, R.2    Wang, L.3
  • 44
    • 84862697766 scopus 로고    scopus 로고
    • Weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients with relapsed and/or refractory multiple myeloma: Results from a Phase 1 doseescalation study
    • Kumar S, Bensinger WI, Reeder CB et al. Weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients with relapsed and/or refractory multiple myeloma: results from a Phase 1 doseescalation study. ASH Annual Meeting Abstracts 118(21), 816 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 816
    • Kumar, S.1    Bensinger, W.I.2    Reeder, C.B.3
  • 45
    • 84863643928 scopus 로고    scopus 로고
    • Phase 1/2 study of oral MLN9708, a novel, investigational proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM)
    • Berdeja JG, Richardson PG, Lonial S et al. Phase 1/2 study of oral MLN9708, a novel, investigational proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM). ASH Annual Meeting Abstracts 118(21), 479 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 479
    • Berdeja, J.G.1    Richardson, P.G.2    Lonial, S.3
  • 46
    • 84870742647 scopus 로고    scopus 로고
    • Oral dosing of the novel proteasome inhibitor CEP-18770 shows marked antimyeloma effects in SCID-Hu models of multiple myeloma
    • Sanchez E, Li M, Steinberg JA et al. Oral dosing of the novel proteasome inhibitor CEP-18770 shows marked antimyeloma effects in SCID-Hu models of multiple myeloma. ASH Annual Meeting Abstracts 114(22), 1840 (2009).
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 1840
    • Sanchez, E.1    Li, M.2    Steinberg, J.A.3
  • 47
    • 41949110089 scopus 로고    scopus 로고
    • CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
    • Piva R, Ruggeri B, Williams M et al. CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood 111(5), 2765-2775 (2008).
    • (2008) Blood , vol.111 , Issue.5 , pp. 2765-2775
    • Piva, R.1    Ruggeri, B.2    Williams, M.3
  • 48
    • 84870755998 scopus 로고    scopus 로고
    • Efficacy and tolerability of CEP-18770 in combination with dexamethasone and lenalidomide using a SCID-Hu model of multiple myeloma (MM)
    • Sanchez E, Nichols CM, Lam AC et al. Efficacy and tolerability of CEP-18770 in combination with dexamethasone and lenalidomide using a SCID-Hu model of multiple myeloma (MM). ASH Annual Meeting Abstracts 118(21), 2946 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 2946
    • Sanchez, E.1    Nichols, C.M.2    Lam, A.C.3
  • 49
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
    • Chauhan D, Catley L, Li G et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 8(5), 407-419 (2005).
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3
  • 50
    • 79951489147 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the novel structure proteasome inhibitor NPI-0052 in patients with relapsed and relapsed/ refractory multiple myeloma (MM)
    • Richardson P, Hofmeister C, Jakubowiak A et al. Phase 1 clinical trial of the novel structure proteasome inhibitor NPI-0052 in patients with relapsed and relapsed/ refractory multiple myeloma (MM). ASH Annual Meeting Abstracts 114(22), 431 (2009).
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 431
    • Richardson, P.1    Hofmeister, C.2    Jakubowiak, A.3
  • 51
    • 77949315484 scopus 로고    scopus 로고
    • Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Ciccarelli B, Richardson PG, Palladino MA, Anderson KC. Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood 115(4), 834-845 (2010).
    • (2010) Blood , vol.115 , Issue.4 , pp. 834-845
    • Chauhan, D.1    Singh, A.V.2    Ciccarelli, B.3    Richardson, P.G.4    Palladino, M.A.5    Anderson, K.C.6
  • 52
    • 78649755360 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Aujay M et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood 116(23), 4906-4915 (2010).
    • (2010) Blood , vol.116 , Issue.23 , pp. 4906-4915
    • Chauhan, D.1    Singh, A.V.2    Aujay, M.3
  • 53
    • 81155138545 scopus 로고    scopus 로고
    • A Phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI ONX 0912 in patients with advanced refractory or recurrent solid tumors
    • Suppl.), Abstract
    • Papadopoulos K, Mendelson D, Tolcher A et al. A Phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors. J. Clin. Oncol. 29(Suppl.), Abstract 3075 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3075
    • Papadopoulos, K.1    Mendelson, D.2    Tolcher, A.3
  • 54
    • 65649139708 scopus 로고    scopus 로고
    • Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)
    • Zhou HJ, Aujay MA, Bennett MK et al. Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J. Med. Chem. 52(9), 3028-3038 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.9 , pp. 3028-3038
    • Zhou, H.J.1    Aujay, M.A.2    Bennett, M.K.3
  • 55
    • 72549116835 scopus 로고    scopus 로고
    • A Phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171 in patients with hematologic malignancies
    • O'Connor OA, Stewart AK, Vallone M et al in patients with hematologic malignancies. Clin. Cancer Res. 15(22), 7085-7091 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.22 , pp. 7085-7091
    • O'Connor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 56
    • 50249150555 scopus 로고    scopus 로고
    • Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies
    • Alsina M, Trudel S, Vallone M, Molineaux C, Kunkel L, Goy A. Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. ASH Annual Meeting Abstracts 110(11), 411 (2007).
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 411
    • Alsina, M.1    Trudel, S.2    Vallone, M.3    Molineaux, C.4    Kunkel, L.5    Goy, A.6
  • 57
    • 70349643684 scopus 로고    scopus 로고
    • Final Results Of PX-171-003-A0 Part 1 Of An Open-label Single-arm Phase II Study Of Carfilzomib (CFZ) In Patients (pts) With Relapsed And Refractory Multiple Myeloma MM)
    • Suppl.), Abstract 8504
    • Jagannath S, Vij R, Stewart K et al. Final results of PX-171-003-A0, part 1 of an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J. Clin. Oncol. 27(15 Suppl.), Abstract 8504 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15
    • Jagannath, S.1    Vij, R.2    Stewart, K.3
  • 58
    • 84857923822 scopus 로고    scopus 로고
    • Final results from the bortezomib-naive group of PX-171-004, a Phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory M.M
    • Vij R, Kaufman JL, Jakubowiak AJ et al Final results from the bortezomib-naive group of PX-171-004, a Phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory MM. ASH Annual Meeting Abstracts 118(21), 813 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 813
    • Vij, R.1    Kaufman, J.L.2    Jakubowiak, A.J.3
  • 59
    • 84862688138 scopus 로고    scopus 로고
    • Interim Results From PX-171-006 A Phase (Ph) II Multicenter Dose-expansion Study Of Carfilzomib (CFZ) Lenalidomide (LEN) And Low-dose Dexamethasone (loDex) In Relapsed Andor Refractory Multiple Myeloma (RR MM)
    • Suppl.) Abstract
    • Wang M, Bensinger W, Martin T et al. Interim results from PX-171-006, a Phase (Ph) II multicenter dose-expansion study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDex) in relapsed and/or refractory multiple myeloma (R/R MM). J. Clin. Oncol. 29(Suppl.) Abstract 8025 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 8025
    • Wang, M.1    Bensinger, W.2    Martin, T.3
  • 60
    • 84863644110 scopus 로고    scopus 로고
    • A randomized, multicenter, Phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (MM)
    • Suppl.), Abstract TPS225
    • Moreau P, Palumbo A, Stewart A et al. A randomized, multicenter, Phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (MM). J. Clin. Oncol. 29(Suppl.), Abstract TPS225 (2011).
    • (2011) J. Clin. Oncol. , vol.29
    • Moreau, P.1    Palumbo, A.2    Stewart, A.3
  • 61
    • 84857261392 scopus 로고    scopus 로고
    • Final results of a frontline Phase 1/2 study of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd in multiple myeloma (MM)
    • Jakubowiak AJ, Dytfeld D, Jagannath S et al. Final results of a frontline Phase 1/2 study of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in multiple myeloma (MM). ASH Annual Meeting Abstracts 118(21), 631 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 631
    • Jakubowiak, A.J.1    Dytfeld, D.2    Jagannath, S.3
  • 62
    • 84864568291 scopus 로고    scopus 로고
    • Carfilzomib combined with thalidomide and dexamethasone (CARTHADEX) as induction treatment prior to high-dose melphalan (HDM) in newly diagnosed patients with multiple myeloma (MM). A trial of the european myeloma network EMN
    • Sonneveld P, Hacker E, Zweegman S et al. Carfilzomib combined with thalidomide and dexamethasone (CARTHADEX) as induction treatment prior to high-dose melphalan (HDM) in newly diagnosed patients with multiple myeloma (MM). A trial of the european myeloma network EMN. ASH Annual Meeting Abstracts 118(21), 633 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 633
    • Sonneveld, P.1    Hacker, E.2    Zweegman, S.3
  • 63
    • 33645659169 scopus 로고    scopus 로고
    • Changes in Mcl-1 and Bim expression with bortezomib and melphalan therapy for multiple myeloma
    • Popat R, Goff L, Oaekervee HE, Cavenagh JD, Joel SP. Changes in Mcl-1 and Bim expression with bortezomib and melphalan therapy for multiple myeloma. ASH Annual Meeting Abstracts 106(11), 2481 (2005).
    • (2005) ASH Annual Meeting Abstracts , vol.106 , Issue.11 , pp. 2481
    • Popat, R.1    Goff, L.2    Oaekervee, H.E.3    Cavenagh, J.D.4    Joel, S.P.5
  • 64
    • 34848833957 scopus 로고    scopus 로고
    • Intergroupe Francophone du Myélome Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): A randomised trial
    • Facon T, Mary JY, Hulin C et al.; Intergroupe Francophone du Myélome. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): A randomised trial. Lancet 370(9594), 1209-1218 (2007).
    • (2007) Lancet , vol.370 , Issue.9594 , pp. 1209-1218
    • Facon, T.1    Mary, J.Y.2    Hulin, C.3
  • 65
    • 68949137225 scopus 로고    scopus 로고
    • Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial
    • Hulin C, Facon T, Rodon P et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial. J. Clin. Oncol. 27(22), 3664-3670 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.22 , pp. 3664-3670
    • Hulin, C.1    Facon, T.2    Rodon, P.3
  • 66
    • 60849131974 scopus 로고    scopus 로고
    • Melphalan + prednisone versus melphalan + prednisone + thalidomide in induction therapy for multiple myeloma in elderly patients: Final analysis of the dutch cooperative group HOVON 49 Study
    • Wijermans P, Schaafsma M, van Norden Y et al. Melphalan + prednisone versus melphalan + prednisone + thalidomide in induction therapy for multiple myeloma in elderly patients: final analysis of the dutch cooperative group HOVON 49 Study. ASH Annual Meeting Abstracts 112(11), 649 (2008).
    • (2008) ASH Annual Meeting Abstracts , vol.112 , Issue.11 , pp. 649
    • Wijermans, P.1    Schaafsma, M.2    Van Norden, Y.3
  • 67
    • 54049135250 scopus 로고    scopus 로고
    • Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: Updated results of a randomized controlled trial
    • Palumbo A, Bringhen S, Liberati AM et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial. Blood 112(8), 3107-3114 (2008).
    • (2008) Blood , vol.112 , Issue.8 , pp. 3107-3114
    • Palumbo, A.1    Bringhen, S.2    Liberati, A.M.3
  • 68
    • 78650159700 scopus 로고    scopus 로고
    • Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: Results of a randomized trial from the Turkish Myeloma Study Group
    • Beksac M, Haznedar R, Firatli-Tuglular T et al. Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: results of a randomized trial from the Turkish Myeloma Study Group. Eur. J. Haematol. 86(1), 16-22 (2011).
    • (2011) Eur. J. Haematol. , vol.86 , Issue.1 , pp. 16-22
    • Beksac, M.1    Haznedar, R.2    Firatli-Tuglular, T.3
  • 69
    • 80051570906 scopus 로고    scopus 로고
    • Thalidomide for previously untreated elderly patients with multiple myeloma: Meta-analysis of 1685 individual patient data from 6 randomized clinical trials
    • Nordic Myeloma Study Group; Italian Multiple Myeloma Network; Turkish Myeloma Study Group; Hemato-Oncologie voor Volwassenen Nederland; Intergroupe Francophone du Myélome; European Myeloma Network.
    • Fayers PM, Palumbo A, Hulin C et al.; Nordic Myeloma Study Group; Italian Multiple Myeloma Network; Turkish Myeloma Study Group; Hemato-Oncologie voor Volwassenen Nederland; Intergroupe Francophone du Myélome; European Myeloma Network. Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials. Blood 118(5), 1239-1247 (2011).
    • (2011) Blood , vol.118 , Issue.5 , pp. 1239-1247
    • Fayers, P.M.1    Palumbo, A.2    Hulin, C.3
  • 70
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
    • Mitsiades N, Mitsiades CS, Poulaki V et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications. Blood 99(12), 4525-4530 (2002).
    • (2002) Blood , vol.99 , Issue.12 , pp. 4525-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 71
    • 79952729549 scopus 로고    scopus 로고
    • Phase II trial of lenalidomide, bortezomib, and dexamethasone in patients (pts) with relapsed and relapsed/refractory multiple myeloma (MM): Updated efficacy and safety data after >2 years of follow-up
    • Richardson PG, Jagannath S, Jakubowiak AJ et al. Phase II trial of lenalidomide, bortezomib, and dexamethasone in patients (pts) with relapsed and relapsed/refractory multiple myeloma (MM): updated efficacy and safety data after >2 years of follow-up. ASH Annual Meeting Abstracts 116(21), 3049 (2010).
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 3049
    • Richardson, P.G.1    Jagannath, S.2    Jakubowiak, A.J.3
  • 72
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 116(5), 679-686 (2010).
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 73
    • 79951797822 scopus 로고    scopus 로고
    • Novel three- and four-drug combination regimens of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide, for previously untreated multiple myeloma: Results from the multicenter, randomized, Phase 2 EVOLUTION study
    • Kumar S, Flinn IW, Richardson PG et al. Novel three- and four-drug combination regimens of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide, for previously untreated multiple myeloma: results from the multicenter, randomized, Phase 2 EVOLUTION study. ASH Annual Meeting Abstracts 116(21), 621 (2010).
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 621
    • Kumar, S.1    Flinn, I.W.2    Richardson, P.G.3
  • 75
    • 33745961875 scopus 로고    scopus 로고
    • Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications
    • Chang DH, Liu N, Klimek V et al. Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications. Blood 108(2), 618-621 (2006).
    • (2006) Blood , vol.108 , Issue.2 , pp. 618-621
    • Chang, D.H.1    Liu, N.2    Klimek, V.3
  • 76
    • 29244488561 scopus 로고    scopus 로고
    • Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications
    • Tai YT, Li XF, Catley L et al. Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications. Cancer Res. 65(24), 11712-11720 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.24 , pp. 11712-11720
    • Tai, Y.T.1    Li, X.F.2    Catley, L.3
  • 77
    • 84859769293 scopus 로고    scopus 로고
    • A Phase 2 study of elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma
    • Lonial S, Jakubowiak AJ, Jagannath S et al. A Phase 2 study of elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma. ASH Annual Meeting Abstracts 118(21), 303 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 303
    • Lonial, S.1    Jakubowiak, A.J.2    Jagannath, S.3
  • 78
    • 84857922830 scopus 로고    scopus 로고
    • Randomized, open label Phase 1/2 study of pomalidomide (POM) alone or in combination with low-dose dexamethasone (LoDex) in patients (Pts) with relapsed and refractory multiple myeloma who have received prior treatment that includes lenalidomide (LEN) and bortezomib (BORT): Phase 2 results
    • Richardson PG, Siegel DS, Vij R et al. Randomized, open label Phase 1/2 study of pomalidomide (POM) alone or in combination with low-dose dexamethasone (LoDex) in patients (Pts) with relapsed and refractory multiple myeloma who have received prior treatment that includes lenalidomide (LEN) and bortezomib (BORT): Phase 2 results. ASH Annual Meeting Abstracts 118(21), 634 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 634
    • Richardson, P.G.1    Siegel, D.S.2    Vij, R.3
  • 79
    • 84857922264 scopus 로고    scopus 로고
    • High response rates to pomalidomide and dexamethasone in patients with refractory myeloma, final analysis of IFM 2009- 02
    • Leleu X, Attal M, Arnulf B et al. High response rates to pomalidomide and dexamethasone in patients with refractory myeloma, final analysis of IFM 2009-02. ASH Annual Meeting Abstracts 118(21), 812 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 812
    • Leleu, X.1    Attal, M.2    Arnulf, B.3
  • 80
    • 84870767282 scopus 로고    scopus 로고
    • A Phase I/II study of pomalidomidecyclophosphamide-prednisone (pcp) in patients with multiple myeloma relapsed/ refractory to lenalidomide
    • Palumbo A, Larocca A, Carella AM et al. A Phase I/II study of pomalidomidecyclophosphamide-prednisone (pcp) in patients with multiple myeloma relapsed/ refractory to lenalidomide. ASH Annual Meeting Abstracts 118(21), 632 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 632
    • Palumbo, A.1    Larocca, A.2    Carella, A.M.3
  • 81
    • 84870751585 scopus 로고    scopus 로고
    • ClaPD (clarithromycin/[Biaxin®] pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma
    • Mark TM, Rodriguez M, Shah M et al. ClaPD (clarithromycin/[Biaxin®], pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma. ASH Annual Meeting Abstracts 118(21), 635 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 635
    • Mark, T.M.1    Rodriguez, M.2    Shah, M.3
  • 82
    • 84862654727 scopus 로고    scopus 로고
    • Bendamustine combined with bortezomib has efficacy in patients with relapsed or refractory multiple myeloma: A Phase 1/2 study
    • Berenson JR, Yellin O, Bessudo A et al. Bendamustine combined with bortezomib has efficacy in patients with relapsed or refractory multiple myeloma: A Phase 1/2 study. ASH Annual Meeting Abstracts 118(21), 1857 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 1857
    • Berenson, J.R.1    Yellin, O.2    Bessudo, A.3
  • 83
    • 84865812815 scopus 로고    scopus 로고
    • Combination of bendamustine, lenalidomide, and dexamethasone (BLD in patients with refractory or relapsed multiple myeloma is safe and highly effective: Results of Phase I/II open-label, dose escalation study
    • Lentzsch S, O'Sullivan A, Kennedy R et al in patients with refractory or relapsed multiple myeloma is safe and highly effective: results of Phase I/II open-label, dose escalation study. ASH Annual Meeting Abstracts 118(21), 304 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 304
    • Lentzsch, S.1    O'Sullivan, A.2    Kennedy, R.3
  • 84
    • 84870748976 scopus 로고    scopus 로고
    • Bortezomib-bendamustine-dexamethasone in patients with relapsed/refractory multiple myeloma (MM) shows marked efficacy and is well tolerated, but assessment of PNP symptoms shows significant discrepancies between patients and physicians
    • Ludwig H, Kasparu H, Linkesch W et al. Bortezomib-bendamustine- dexamethasone in patients with relapsed/refractory multiple myeloma (MM) shows marked efficacy and is well tolerated, but assessment of PNP symptoms shows significant discrepancies between patients and physicians. ASH Annual Meeting Abstracts 118(21), 2928 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 2928
    • Ludwig, H.1    Kasparu, H.2    Linkesch, W.3
  • 85
    • 84869173839 scopus 로고    scopus 로고
    • Maintenance therapy in multiple myeloma
    • Harousseau J-L. Maintenance therapy in multiple myeloma. Hematol. Rev. 1(2), e12 (2009).
    • (2009) Hematol. Rev. , vol.1 , Issue.2
    • Harousseau, J.-L.1
  • 86
    • 84856949640 scopus 로고    scopus 로고
    • Sequential bortezomib, dexamethasone, and thalidomide maintenance therapy after single autologous peripheral stem cell transplantation in patients with multiple myeloma
    • Sahebi F, Frankel PH, Farol L et al. Sequential bortezomib, dexamethasone, and thalidomide maintenance therapy after single autologous peripheral stem cell transplantation in patients with multiple myeloma. Biol. Blood Marrow Transplant. 18(3), 486-492 (2012).
    • (2012) Biol. Blood Marrow Transplant. , vol.18 , Issue.3 , pp. 486-492
    • Sahebi, F.1    Frankel, P.H.2    Farol, L.3
  • 87
    • 84870760136 scopus 로고    scopus 로고
    • Survival Outcomes Of Early Autologous Stem Cell Transplant (ASCT) Followed By Lenalidomide Bortezomib And Dexamethasone (RVD) Maintenance In Patients With High-risk Multiple Myeloma (MM)
    • Suppl.) Abstract
    • Kaufman JL, Nooka AK, Muppidi S et al. Survival outcomes of early autologous stem cell transplant (ASCT) followed by lenalidomide, bortezomib, and dexamethasone (RVD) maintenance in patients with high-risk multiple myeloma (MM). J. Clin. Oncol. 30(Suppl.), Abstract 8100 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 8100
    • Kaufman, J.L.1    Nooka, A.K.2    Muppidi, S.3
  • 88
    • 5644250621 scopus 로고    scopus 로고
    • A Phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
    • Jagannath S, Barlogie B, Berenson J et al. A Phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br. J. Haematol. 127(2), 165-172 (2004).
    • (2004) Br. J. Haematol. , vol.127 , Issue.2 , pp. 165-172
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.3
  • 89
    • 34848815741 scopus 로고    scopus 로고
    • The combination of cyclophosphamide, velcade and dexamethasone induces high response rates with comparable toxicity to velcade alone and velcade plus dexamethasone
    • Davies FE, Wu P, Jenner M, Srikanth M, Saso R, Morgan GJ. The combination of cyclophosphamide, velcade and dexamethasone induces high response rates with comparable toxicity to velcade alone and velcade plus dexamethasone. Haematologica 92(8), 1149-1150 (2007).
    • (2007) Haematologica , vol.92 , Issue.8 , pp. 1149-1150
    • Davies, F.E.1    Wu, P.2    Jenner, M.3    Srikanth, M.4    Saso, R.5    Morgan, G.J.6
  • 90
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R et al. Antitumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Med. 341(21), 1565-1571 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 91
    • 0034899464 scopus 로고    scopus 로고
    • Thalidomide and dexamethasone combination for refractory multiple myeloma
    • Dimopoulos MA, Zervas K, Kouvatseas G et al. Thalidomide and dexamethasone combination for refractory multiple myeloma. Ann. Oncol. 12(7), 991-995 (2001).
    • (2001) Ann. Oncol. , vol.12 , Issue.7 , pp. 991-995
    • Dimopoulos, M.A.1    Zervas, K.2    Kouvatseas, G.3
  • 92
    • 11144356289 scopus 로고    scopus 로고
    • Pulsed cyclophosphamide, thalidomide and dexamethasone: An oral regimen for previously treated patients with multiple myeloma
    • Dimopoulos MA, Hamilos G, Zomas A, et al. Pulsed cyclophosphamide, thalidomide and dexamethasone: An oral regimen for previously treated patients with multiple myeloma. Hematol. J. 5, 112-117 (2004).
    • (2004) Hematol. J. , vol.5 , pp. 112-117
    • Dimopoulos, M.A.1    Hamilos, G.2    Zomas, A.3
  • 93
    • 77950563131 scopus 로고    scopus 로고
    • Korean Multiple Myeloma Working Party (KMMWP). Clinical efficacy of a bortezomib, cyclophosphamide, thalidomide, and dexamethasone (Vel-CTD) regimen in patients with relapsed or refractory multiple myeloma: A Phase II study
    • Kim YK, Sohn SK, Lee JH et al.; Korean Multiple Myeloma Working Party (KMMWP). Clinical efficacy of a bortezomib, cyclophosphamide, thalidomide, and dexamethasone (Vel-CTD) regimen in patients with relapsed or refractory multiple myeloma: A Phase II study. Ann. Hematol. 89(5), 475-482 (2010).
    • (2010) Ann. Hematol. , vol.89 , Issue.5 , pp. 475-482
    • Kim, Y.K.1    Sohn, S.K.2    Lee, J.H.3
  • 94
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson PG, Schlossman RL, Weller E et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 100(9), 3063-3067 (2002).
    • (2002) Blood , vol.100 , Issue.9 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3
  • 95
    • 36349010285 scopus 로고    scopus 로고
    • Multiple Myeloma (009) Study Investigators. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber DM, Chen C, Niesvizky R et al.; Multiple Myeloma (009) Study Investigators. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N. Engl. J. Med. 357(21), 2133-2142 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , Issue.21 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 96
    • 36349023319 scopus 로고    scopus 로고
    • Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
    • Dimopoulos M, Spencer A, Attal M et al.; Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N. Engl. J. Med. 357(21), 2123-2132 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , Issue.21 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 97
    • 84859725663 scopus 로고    scopus 로고
    • Salvage therapy with vorinostat, lenalidomide, and dexamethasone (ZRD) in lenalidomide/dexamethasone relapsed/refractory multiple myeloma
    • Richter JR, Bilotti E, McBride L et al. Salvage therapy with vorinostat, lenalidomide, and dexamethasone (ZRD) in lenalidomide/dexamethasone relapsed/refractory multiple myeloma. ASH Annual Meeting Abstracts 118(21), 3986 (2011).
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3986
    • Richter, J.R.1    Bilotti, E.2    McBride, L.3
  • 98
    • 70249146895 scopus 로고    scopus 로고
    • Single-agent bortezomib in previously untreated multiple myeloma: Efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy
    • Richardson PG, Xie W, Mitsiades C et al. Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy. J. Clin. Oncol. 27(21), 3518-3525 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.21 , pp. 3518-3525
    • Richardson, P.G.1    Xie, W.2    Mitsiades, C.3
  • 99
    • 78049488759 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: Results of the IFM 2005-01 Phase III trial
    • Harousseau JL, Attal M, Avet-Loiseau H et al. Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 Phase III trial. J. Clin. Oncol. 28(30), 4621-4629 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.30 , pp. 4621-4629
    • Harousseau, J.L.1    Attal, M.2    Avet-Loiseau, H.3
  • 100
    • 66849104712 scopus 로고    scopus 로고
    • Efficacy of induction with CyBorD in newly diagnosed multiple myeloma
    • Suppl.) Abstract 8517
    • Reeder C, Stewart A, Hentz J et al. Efficacy of induction with CyBorD in newly diagnosed multiple myeloma. J. Clin. Oncol. 26(Suppl.) Abstract 8517 (2008).
    • (2008) J. Clin. Oncol. , vol.26
    • Reeder, C.1    Stewart, A.2    Hentz, J.3
  • 101
    • 43749117945 scopus 로고    scopus 로고
    • Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma
    • Rajkumar SV, Rosiñol L, Hussein M et al. Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma. J. Clin. Oncol. 26(13), 2171-2177 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.13 , pp. 2171-2177
    • Rajkumar, S.V.1    Rosiñol, L.2    Hussein, M.3
  • 102
    • 38549144944 scopus 로고    scopus 로고
    • Thalidomide In Induction Treatment Increases The Very Good Partial Response Rate Before And After High-dose Therapy In Previously Untreated Multiple Myeloma
    • Dutch-Belgian HOVON; German GMMG
    • Lokhorst HM, Schmidt-Wolf I, Sonneveld P et al.; Dutch-Belgian HOVON; German GMMG. Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma. Haematologica 93(1), 124-127 (2008).
    • (2008) Haematologica , vol.93 , Issue.1 , pp. 124-127
    • Lokhorst, H.M.1    Schmidt-Wolf, I.2    Sonneveld, P.3
  • 103
    • 79952790841 scopus 로고    scopus 로고
    • HOVON-65/GMMG-HD4 randomized Phase III trial comparing bortezomib, doxorubicin, dexamethasone (PAD vs VAD followed by high-dose melphalan (HDM) and maintenance with bortezomib or thalidomide in patients with newly diagnosed multiple myeloma (MM)
    • Sonneveld P, Schmidt-Wolf I, van der Holt B et al. HOVON-65/GMMG-HD4 randomized Phase III trial comparing bortezomib, doxorubicin, dexamethasone (PAD) vs VAD followed by high-dose melphalan (HDM) and maintenance with bortezomib or thalidomide in patients with newly diagnosed multiple myeloma (MM). ASH Annual Meeting Abstracts 116(21), 40 (2010).
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 40
    • Sonneveld, P.1    Schmidt-Wolf, I.2    Van Der Holt, B.3
  • 104
    • 58149376363 scopus 로고    scopus 로고
    • Thalidomide combinations improve response rates; results from the MRC IX study
    • Morgan GJ, Davies FE, Owen RG et al. Thalidomide combinations improve response rates; results from the MRC IX study. ASH Annual Meeting Abstracts 110(11), 3593 (2007).
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 3593
    • Morgan, G.J.1    Davies, F.E.2    Owen, R.G.3
  • 105
    • 78650303860 scopus 로고    scopus 로고
    • GIMEMA Italian Myeloma Network Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: A randomised Phase 3 study
    • Cavo M, Tacchetti P, Patriarca F et al. GIMEMA Italian Myeloma Network. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: A randomised Phase 3 study. Lancet 376(9758), 2075-2085 (2010).
    • (2010) Lancet , vol.376 , Issue.9758 , pp. 2075-2085
    • Cavo, M.1    Tacchetti, P.2    Patriarca, F.3
  • 106
    • 82155178738 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment prior to autologous stem cell transplantation in newly diagnosed multiple myeloma
    • Moreau P, Avet-Loiseau H, Facon T et al. Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment prior to autologous stem cell transplantation in newly diagnosed multiple myeloma. Blood 118(22), 5752-5758 (2011).
    • (2011) Blood , vol.118 , Issue.22 , pp. 5752-5758
    • Moreau, P.1    Avet-Loiseau, H.2    Facon, T.3
  • 107
    • 73249146496 scopus 로고    scopus 로고
    • Eastern Cooperative Oncology Group. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial
    • Rajkumar SV, Jacobus S, Callander NS et al.; Eastern Cooperative Oncology Group. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial. Lancet Oncol. 11(1), 29-37 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.1 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3
  • 108
    • 70449567928 scopus 로고    scopus 로고
    • Phase II trial of lenalidomide (RevlimidTM) with cyclophosphamide and dexamethasone (RCd) for newly diagnosed myeloma
    • Kumar S, Hayman S, Buadi F et al. Phase II trial of lenalidomide (RevlimidTM) with cyclophosphamide and dexamethasone (RCd) for newly diagnosed myeloma. ASH Annual Meeting Abstracts 112(11), 91 (2008).
    • (2008) ASH Annual Meeting Abstracts , vol.112 , Issue.11 , pp. 91
    • Kumar, S.1    Hayman, S.2    Buadi, F.3
  • 109
    • 79960666079 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, pegylated liposomal doxorubicin, and dexamethasone in newly diagnosed multiple myeloma: A Phase 1/2 Multiple Myeloma Research Consortium trial
    • Jakubowiak AJ, Griffith KA, Reece DE et al. Lenalidomide, bortezomib, pegylated liposomal doxorubicin, and dexamethasone in newly diagnosed multiple myeloma: A Phase 1/2 Multiple Myeloma Research Consortium trial. Blood 118(3), 535-543 (2011).
    • (2011) Blood , vol.118 , Issue.3 , pp. 535-543
    • Jakubowiak, A.J.1    Griffith, K.A.2    Reece, D.E.3
  • 110
    • 84870763734 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone (RVD) in combination with vorinostat as front-line therapy for patients with multiple myeloma (MM): Initial results of a Phase 1 study
    • Kaufman JL, Shah JJ, Laubach JP et al. Lenalidomide, bortezomib, and dexamethasone (RVD) in combination with vorinostat as front-line therapy for patients with multiple myeloma (MM): initial results of a Phase 1 study. ASH Annual Meeting Abstracts 116(21), 3034 (2010).
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 3034
    • Kaufman, J.L.1    Shah, J.J.2    Laubach, J.P.3


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