Association of Genetic Loci with Sleep Apnea in European Americans and African-Americans: The Candidate Gene Association Resource (CARe)

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Patel, Sanjay R ^a   Goodloe, Robert ^b   De, Gourab ^c   Kowgier, Matthew ^d   Weng, Jia ^a   Buxbaum, Sarah G ^e,f   Cade, Brian ^a   Fulop, Tibor ^g   Gharib, Sina A ^h   Gottlieb, Daniel J ^a,i,j,k   Hillman, David ^l   Larkin, Emma K ^m   Lauderdale, Diane S ⁿ   Li, Li ^o   Mukherjee, Sutapa ^l,p,q   Palmer, Lyle ^d   Zee, Phyllis ^r   Zhu, Xiaofeng ^o   Redline, Susan ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d MOUNT SINAI HOSPITAL   (Canada)

^e Jackson Heart Study   (United States)

^f JACKSON STATE UNIVERSITY   (United States)

^g UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

ⁱ VETERANS AFFAIRS MEDICAL CENTER   (United States)

^j FRAMINGHAM HEART STUDY   (United States)

^k BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^m VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

ⁿ UNIVERSITY OF CHICAGO   (United States)

^o CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^p UNIVERSITY OF TORONTO   (Canada)

^q WOMEN S COLLEGE HOSPITAL   (Canada)

^r NORTHWESTERN UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 2; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; EUROPEAN AMERICAN; FEMALE; GENE; GENE ACTIVITY; GENE FUNCTION; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; INFLAMMATION; LPAR1 GENE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PHENOTYPE; PTGER3 GENE; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP DISORDERED BREATHING;

ADULT; AFRICAN AMERICANS; AGED; ALLELES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYSOMNOGRAPHY; SLEEP APNEA, OBSTRUCTIVE;

EID: 84869110487     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048836     Document Type: Article

References (42)

1. Young T, Peppard PE, Taheri S, (2005) Excess weight and sleep-disordered breathing. J Appl Physiol 99: 1592-1599.
2. Peppard PE, Young T, Palta M, Skatrud J, (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342: 1378-1384.
3. Marin JM, Carrizo SJ, Vicente E, Agusti AG, (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365: 1046-1053.
4. Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, et al. (2002) Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 165: 677-682.
5. Gottlieb DJ, Whitney CW, Bonekat WH, Iber C, James GD, et al. (1999) Relation of sleepiness to respiratory disturbance index: the Sleep Heart Health Study. Am J Respir Crit Care Med 159: 502-507.
6. Teran-Santos J, Jimenez-Gomez A, Cordero-Guevara J, (1999) The association between sleep apnea and the risk of traffic accidents. Cooperative Group Burgos-Santander. N Engl J Med 340: 847-851.
7. Kryger MH, Roos L, Delaive K, Walld R, Horrocks J, (1996) Utilization of health care services in patients with severe obstructive sleep apnea. Sleep 19: S111-116.
8. Redline S, Tishler PV, Tosteson TD, Williamson J, Kump K, et al. (1995) The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 151: 682-687.
9. Mathur R, Douglas NJ, (1995) Family studies in patients with the sleep apnea-hypopnea syndrome. Ann Intern Med 122: 174-178.
10. Carmelli D, Colrain IM, Swan GE, Bliwise DL, (2004) Genetic and environmental influences in sleep-disordered breathing in older male twins. Sleep 27: 917-922.
11. Patel SR, Larkin EK, Redline S, (2008) Shared genetic basis for obstructive sleep apnea and adiposity measures. Int J Obes (Lond) 32: 795-800.
12. Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, et al. (2008) Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 3: e3583.
13. Rust G, Fryer GE Jr, Phillips RL Jr, Daniels E, Strothers H, et al. (2004) Modifiable determinants of healthcare utilization within the African-American population. J Natl Med Assoc 96: 1169-1177.
14. Rosen CL, Larkin EK, Kirchner HL, Emancipator JL, Bivins SF, et al. (2003) Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children: association with race and prematurity. J Pediatr 142: 383-389.
15. Young T, Palta M, Dempsey J, Skatrud J, Weber S, et al. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328: 1230-1235.
16. Ferreira MA, Hottenga JJ, Warrington NM, Medland SE, Willemsen G, et al. (2009) Sequence variants in three loci influence monocyte counts and erythrocyte volume. Am J Hum Genet 85: 745-749.
17. Maugeri N, Powell JE, t Hoen PA, de Geus EJ, Willemsen G, et al. (2011) LPAR1 and ITGA4 regulate peripheral blood monocyte counts. Hum Mutat 32: 873-876.
18. Hecht JH, Weiner JA, Post SR, Chun J, (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 135: 1071-1083.
19. Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J, (2000) Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A 97: 13384-13389.
20. Lian L, Wang Y, Flick M, Choi J, Scott EW, et al. (2009) Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood 113: 3577-3584.
21. Wilker E, Mittleman MA, Litonjua AA, Poon A, Baccarelli A, et al. (2009) Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. Environ Health Perspect 117: 935-940.
22. Wilker EH, Alexeeff SE, Poon A, Litonjua AA, Sparrow D, et al. (2009) Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men. Atherosclerosis 206: 480-485.
23. Sober S, Org E, Kepp K, Juhanson P, Eyheramendy S, et al. (2009) Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. PLoS One 4: e6034.
24. Larkin EK, Patel SR, Goodloe RJ, Li Y, Zhu X, et al. (2010) A candidate gene study of obstructive sleep apnea in European Americans and African Americans. Am J Respir Crit Care Med 182: 947-953.
25. Buxbaum SG, Elston RC, Tishler PV, Redline S, (2002) Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis. Genet Epidemiol 22: 243-253.
26. Zhu X, Young JH, Fox E, Keating BJ, Franceschini N, et al. (2011) Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium. Hum Mol Genet 20: 2285-2295.
27. Boyd JH, Petrof BJ, Hamid Q, Fraser R, Kimoff RJ, (2004) Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J Respir Crit Care Med 170: 541-546.
28. Kimoff RJ, Hamid Q, Divangahi M, Hussain S, Bao W, et al. (2011) Increased upper airway cytokines and oxidative stress in severe obstructive sleep apnoea. Eur Respir J 38: 89-97.
29. Quan SF, Howard BV, Iber C, Kiley JP, Nieto FJ, et al. (1997) The Sleep Heart Health Study: design, rationale, and methods. Sleep 20: 1077-1085.
30. Mukherjee S, Hillman D, Lee J, Fedson A, Simpson L, et al. (2012) Cohort profile: the Western Australian Sleep Health Study. Sleep Breath 16: 205-215.
31. Thompson CL, Larkin EK, Patel S, Berger NA, Redline S, et al. (2011) Short duration of sleep increases risk of colorectal adenoma. Cancer 117: 841-847.
32. Redline S, Sanders MH, Lind BK, Quan SF, Iber C, et al. (1998) Methods for obtaining and analyzing unattended polysomnography data for a multicenter study. Sleep Heart Health Research Group. Sleep 21: 759-767.
33. Palmer LJ, Buxbaum SG, Larkin E, Patel SR, Elston RC, et al. (2003) A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet 72: 340-350.
34. Redline S, Schluchter MD, Larkin EK, Tishler PV, (2003) Predictors of longitudinal change in sleep-disordered breathing in a nonclinic population. Sleep 26: 703-709.
35. American Academy of Sleep Medicine Task Force (1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 22: 667-689.
36. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909.
37. Zhu X, Zhang S, Zhao H, Cooper RS, (2002) Association mapping, using a mixture model for complex traits. Genet Epidemiol 23: 181-196.
38. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
39. Chen MH, Yang Q, (2010) GWAF: an R package for genome-wide association analyses with family data. Bioinformatics 26: 580-581.
40. Willer CJ, Li Y, Abecasis GR, (2010) METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26: 2190-2191.
41. Nyholt DR, (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74: 765-769.
42. Li J, Ji L, (2005) Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95: 221-227.