Shared genetic basis for obstructive sleep apnea and adiposity measures

International Journal of Obesity

Volumn 32, Issue 5, 2008, Pages 795-800

  Patel, S R ^a   Larkin, E K ^b   Redline, S ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Genetic correlation; Genetics; Heritability; Sleep apnea

Indexed keywords

ADIPONECTIN; LEPTIN; RESISTIN;

ANTHROPOMETRY; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENETIC ASSOCIATION; GENETIC CORRELATION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; SLEEP APNEA SYNDROME;

ADIPOSITY; ADULT; BODY MASS INDEX; EPIDEMIOLOGIC METHODS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; OBESITY; PHENOTYPE; POLYSOMNOGRAPHY; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME; WAIST-HIP RATIO;

EID: 43449096920     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803803     Document Type: Article

References (25)

1. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002; 165: 1217-1239.
2. Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000; 284: 3015-3021.
3. Patel SR. Shared genetic risk factors for obstructive sleep apnea and obesity. J Appl Physiol 2005; 99: 1600-1606.
4. Redline S, Tishler PV, Tosteson TD, Williamson J, Kump K, Browner I et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995; 151: 682-687.
5. Carmelli D, Colrain IM, Swan GE, Bliwise DL. Genetic and environmental influences in sleep-disordered breathing in older male twins. Sleep 2004; 27: 917-922.
6. Mathur R, Douglas NJ. Family studies in patients with the sleep apnea-hypopnea syndrome. Ann Intern Med 1995; 122: 174-178.
7. Gislason T, Johannsson JH, Haraldsson A, Olafsdottir BR, Jonsdottir H, Kong A et al. Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome. Am J Respir Crit Care Med 2002; 166: 833-838.
8. Pillar G, Lavie P. Assessment of the role of inheritance in sleep apnea syndrome. Am J Respir Crit Care Med 1995; 151: 688-691.
9. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA 1986; 256: 51-54.
10. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE. The body-mass index of twins who have been reared apart. N Engl J Med 1990; 322: 1483-1487.
11. Davies RJ, Ali NJ, Stradling JR. Neck circumference and other clinical features in the diagnosis of the obstructive sleep apnoea syndrome. Thorax 1992; 47: 101-105.
12. Grunstein R, Wilcox I, Yang TS, Gould Y, Hedner J. Snoring and sleep apnoea in men: association with central obesity and hypertension. Int J Obes 1993; 17: 533-540.
13. Selby JV, Newman B, Quesenberry Jr CP, Fabsitz RR, King MC, Meaney FJ. Evidence of genetic influence on central body fat in middle-aged twins. Hum Biol 1989; 61: 179-194.
14. Buxbaum SG, Elston RC, Tishler PV, Redline S. Genetics of the apnea hypopnea index in Caucasians and African Americans: I. segregation analysis. Genet Epidemiol 2002; 22: 243-253.
15. Redline S, Schluchter MD, Larkin EK, Tishler PV. Predictors of longitudinal change in sleep-disordered breathing in a nonclinic population. Sleep 2003; 26: 703-709.
16. Palmer LJ, Buxbaum SG, Larkin E, Patel SR, Elston RC, Tishler PV et al. A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet 2003; 72: 340-350.
17. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62: 1198-1211.
18. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79-83.
19. Palmer LJ, Buxbaum SG, Larkin EK, Patel SR, Elston RC, Tishler PV et al. Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med 2004; 169: 1314-1321.
20. Tang W, Hong Y, Province MA, Rich SS, Hopkins PN, Arnett DK et al. Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Diabetes Care 2006; 29: 631-636.
21. O'Donnell CP, Schaub CD, Haines AS, Berkowitz DE, Tankersley CG, Schwartz AR et al. Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med 1999; 159: 1477-1484.
22. Menzaghi C, Coco A, Salvemini L, Thompson R, De Cosmo S, Doria A et al. Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians. J Clin Endocrinol Metab 2006; 91: 2792-2795.
23. Comuzzie AG, Hixson JE, Almasy L, Mitchell BD, Mahaney MC, Dyer TD et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997; 15: 273-276.
24. Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 2001; 86: 4321-4325.
25. Larkin EK, Patel SR, Elston RC, Redline S. Linkage analyses of sleep disordered breathing using alternative measures of the apnea hypopnea index (AHI) (abstract). Proc Am Thorac Soc 2006; 3: A568.