Increased upper airway cytokines and oxidative stress in severe obstructive sleep apnoea

European Respiratory Journal

Volumn 38, Issue 1, 2011, Pages 89-97

  Kimoff, R J ^a,b   Hamid, Q ^a   Divangahi, M ^a   Hussain, S ^a,b   Bao, W ^a   Naor, N ^b   Payne, R J ^b   Ariyarajah, A ^a   Mulrain, K ^a   Petrof, B J ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Cytokine; Fibrosis; Inflammation; Obstructive sleep apnoea; Oxidative stress

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; L SELECTIN; RANTES; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SLEEP APNEA SYNDROME; SMOOTH MUSCLE FIBER; UPPER RESPIRATORY TRACT;

ADULT; CYTOKINES; FEMALE; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-1ALPHA; INTERLEUKIN-6; MALE; MIDDLE AGED; OXIDATIVE STRESS; POLYSOMNOGRAPHY; SLEEP APNEA, OBSTRUCTIVE; TRANSFORMING GROWTH FACTOR BETA;

EID: 79960171371     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00048610     Document Type: Article

References (43)

1. Bergeron C, Kimoff J, Hamid Q. Obstructive sleep apnea syndrome and inflammation. J Allergy Clin Immunol 2005; 116: 1393-1396. (Pubitemid 41740957)
2. Arnardottir ES, Mackiewicz M, Gislason T, et al. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep 2009; 32: 447-470.
3. Rubinstein I. Nasal inflammation in patients with obstructive sleep apnea. Laryngoscope 1995; 105: 175-177.
4. Boyd JH, Petrof BJ, Hamid Q, et al. Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J Respir Crit Care Med 2004; 170: 541-546. (Pubitemid 39209137)
5. Payne RJ, Kost KM, Frenkiel S, et al. Laryngeal inflammation assessed using the reflux finding score in obstructive sleep apnea. Otolaryngol Head Neck Surg 2006; 134: 836-842.
6. Lavie L. Obstructive sleep apnoea syndrome: an oxidative stress disorder. Sleep Med Rev 2003; 7: 35-51. (Pubitemid 36188305)
7. Depalo A, Carpagnano GE, Spanevello A, et al. Exhaled NO and iNOS expression in sputum cells of healthy, obese and OSA subjects. J Intern Med 2008; 263: 70-78. (Pubitemid 350243547)
8. Carpagnano GE, Kharitonov SA, Resta O, et al. Increased 8- isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest 2002; 122: 1162-1167. (Pubitemid 35339525)
9. Devouassoux G, Levy P, Rossini E, et al. Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness. J Allergy Clin Immunol 2007; 119: 597-603.
10. Salerno FG, Carpagnano E, Guido P, et al. Airway inflammation in patients affected by obstructive sleep apnea syndrome. Respir Med 2004; 98: 25-28. (Pubitemid 38100751)
11. Paulsen FP, Steven P, Tsokos M, et al. Upper airway epithelial structural changes in obstructive sleep-disordered breathing. Am J Respir Crit Care Med 2002; 166: 501-509.
12. Series F, Chakir J, Boivin D. Influence of weight and sleep apnea status on immunologic and structural features of the uvula. Am J Respir Crit Care Med 2004; 170: 1114-1119. (Pubitemid 39488625)
13. Dempsey JA, Veasey SC, Morgan BJ, et al. Pathophysiology of sleep apnea. Physiol Rev 2010; 90: 47-112.
14. Wilcox P, Milliken C, Bressler B. High-dose tumor necrosis factor a produces an impairment of hamster diaphragm contractility. Am J Respir Crit Care Med 1996; 153: 1611-1615. (Pubitemid 126423113)
15. Reid MB. Free radicals and muscle fatigue: of ROS, canaries, and the IOC. Free Radic Biol Med 2008; 44: 169-179.
16. Dunleavy M, Bradford A, O'Halloran KD. Oxidative stress impairs upper airway muscle endurance in an animal model of sleep-disordered breathing. Adv Exp Med Biol 2008; 605: 458-462.
17. Woodson BT, Garancis JC, Toohill RJ. Histopathologic changes in snoring and obstructive sleep apnea syndrome. Laryngoscope 1991; 101: 1318-1322.
18. Berger G, Gilbey P, Hammel I, et al. Histopathology of the uvula and the soft palate in patients with mild, moderate, and severe obstructive sleep apnea. Laryngoscope 2002; 112: 357-363. (Pubitemid 34135885)
19. Lindman R, Stahl PS. Abnormal palatopharyngeal muscle morphology in sleep-disordered breathing. J Neurol Sci 2002; 195: 11-23. (Pubitemid 34175094)
20. Ferini-Strambi LJ, Smirne S, Moz U, et al. Muscle fibre type and obstructive sleep apnea. Sleep Res Online 1998; 1: 24-27.
21. Series F, Cote C, St Pierre S. Dysfunctional mechanical coupling of upper airway tissues in sleep apnea syndrome. Am J Respir Crit Care Med 1999; 159: 1551-1555. (Pubitemid 29227868)
22. Champagne K, Schwartzman K, Opatrny L, et al. Obstructive sleep apnoea and its association with gestational hypertension. Eur Respir J 2009; 33: 559-565.
23. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Technique and Scoring System for Sleep Stages of Human Sleep. Los Angeles, UCLA, 1968.
24. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992; 15: 173-184.
25. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22: 667-689.
26. Divangahi M, Demoule A, Danialou G, et al. Impact of IL-10 on diaphragmatic cytokine expression and contractility during Pseudomonas infection. Am J Respir Cell Mol Biol 2007; 36: 504-512. (Pubitemid 46623010)
27. Pepe C, Foley S, Shannon J, et al. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol 2005; 116: 544-549. (Pubitemid 41267126)
28. Barreiro E, Gea J, Di FM, et al. Protein carbonyl formation in the diaphragm. Am J Respir Cell Mol Biol 2005; 32: 9-17. (Pubitemid 40053299)
29. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008; 88: 1379-1406.
30. 1 and interferon-γ. Am J Physiol Lung Cell Mol Physiol 2002; 283: L806-L814.
31. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210. (Pubitemid 351160157)
32. Loubaki L, Jacques E, Semlali A, et al. Tumor necrosis factor-α expression in uvular tissues differs between snorers and apneic patients. Chest 2008; 134: 911-918.
33. Demoule A, Divangahi M, Danialou G, et al. Expression and regulation of CC class chemokines in the dystrophic (mdx) diaphragm. Am J Respir Cell Mol Biol 2005; 33: 178-185. (Pubitemid 41473055)
34. Kneuer C, Ehrhardt C, Radomski MW, et al. Selectins: potential pharmacological targets? Drug Discov Today 2006; 11: 1034-1040.
35. Yahiaoui L, Gvozdic D, Danialou G, et al. CC family chemokines directly regulate myoblast responses to skeletal muscle injury. J Physiol 2008; 586: 3991-4004.
36. Petrof BJ, Pack AI, Kelly AM, et al. Pharyngeal myopathy of loaded upper airway in dogs with sleep apnea. J Appl Physiol 1994; 76: 1746-1752. (Pubitemid 24125697)
37. Series F, Simoneau J-A, St. Pierre S, et al. Characteristics of the genioglossus and musculus uvulae in sleep apnea hypopnea syndrome and in snorers. Am J Respir Crit Care Med 1996; 153: 1870-1874. (Pubitemid 26187913)
38. Carrera M, Barbe F, Sauleda J, et al. Effects of obesity upon genioglossus structure and function in obstructive sleep apnoea. Eur Respir J 2004; 23: 425-429. (Pubitemid 38344380)
39. Berger G, Finkelstein Y, Ophir D. Histopathologic changes of the soft palate after laser-assisted uvulopalatoplasty. Arch Otolaryngol Head Neck Surg 1999; 125: 786-790. (Pubitemid 29323921)
40. Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 2005; 112: 2660-2667. (Pubitemid 41532603)
41. Demoule A, Divangahi M, Yahiaoui L, et al. Endotoxin triggers nuclear factor-κB-dependent up-regulation of multiple proinflammatory genes in the diaphragm. Am J Respir Crit Care Med 2006; 174: 646-653. (Pubitemid 44395331)
42. Cregger M, Berger AJ, Rimm DL. Immunohistochemistry and quantitative analysis of protein expression. Arch Pathol Lab Med 2006; 130: 1026-1030. (Pubitemid 44061434)
43. Taylor CR, Levenson RM. Quantification of immunohistochemistry: issues concerning methods, utility and semiquantitative assessment II. Histopathology 2006; 49: 411-424. (Pubitemid 44401549)