A bimodular mechanism of calcium control in eukaryotes

Nature

Volumn 491, Issue 7424, 2012, Pages 468-472

  Tidow, Henning ^a,d   Poulsen, Lisbeth R ^a,b   Andreeva, Antonina ^c   Knudsen, Michael ^a   Hein, Kim L ^a   Wiuf, Carsten ^b   Palmgren, Michael G ^a,b   Nissen, Poul ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALMODULIN; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

BIOINFORMATICS; CALCIUM; CATION; CONCENTRATION (COMPOSITION); CRYSTAL STRUCTURE; EUKARYOTE; GENE EXPRESSION; INHIBITION; MEMBRANE; MOLECULAR ANALYSIS; STOICHIOMETRY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM BINDING; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; EUKARYOTE; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY;

AMINO ACID SEQUENCE; ARABIDOPSIS; ARABIDOPSIS PROTEINS; BINDING SITES; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CALMODULIN; ENZYME ACTIVATION; EUKARYOTA; INTRACELLULAR SPACE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EUKARYOTA;

EID: 84869097530     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11539     Document Type: Article

References (28)

1. Clapham, D. E. Calcium signaling. Cell 131, 1047-1058 (2007).
2. Carafoli, E. Calcium signaling: a tale for all seasons. Proc. Natl Acad. Sci. USA 99, 1115-1122 (2002).
3. Ghosh, A. & Greenberg, M. E. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268, 239-247 (1995).
4. Berridge, M. J. Inositol trisphosphate and calciumsignalling. Nature 361, 315-325 (1993).
5. Strehler, E. E., Filoteo, A. G., Penniston, J. T. & Caride, A. J. Plasma-membrane Ca(21) pumps: structural diversity as the basis for functional versatility. Biochem. Soc. Trans. 35, 919-922 (2007).
6. Brini, M. & Carafoli, E. Calcium pumps in health and disease. Physiol. Rev. 89, 1341-1378 (2009).
7. Brini, M. & Carafoli, E. The plasma membrane Ca21 ATPase and the plasma membrane sodiumcalciumexchanger cooperate in the regulation of cell calcium. Cold Spring Harb. Perspect. Biol. 3, 1-15 (2011).
8. Axelsen, K. B. & Palmgren, M. G. Evolution of substrate specificities in the P-type ATPase superfamily. J. Mol. Evol. 46, 84-101 (1998).
9. Malmström, S., Askerlund, P. & Palmgren, M. G. A calmodulin-stimulated Ca21- ATPase from plant vacuolar membranes with a putative regulatory domain at its N-terminus. FEBS Lett. 400, 324-328 (1997).
10. Falchetto, R., Vorherr, T., Brunner, J. & Carafoli, E. The plasma membrane Ca21 pump contains a site that interacts with its calmodulin-binding domain. J. Biol. Chem. 266, 2930-2936 (1991).
11. Falchetto, R., Vorherr, T. & Carafoli, E. The calmodulin-binding site of the plasma membrane Ca21 pump interacts with the transduction domain of the enzyme. Protein Sci. 1, 1613-1621 (1992).
12. Bonza, M. C. & Luoni, L. Plant and animal type 2B Ca21-ATPases: evidence for a common auto-inhibitory mechanism. FEBS Lett. 584, 4783-4788 (2010).
13. Carafoli, E. Biogenesis: plasma membrane calcium ATPase: 15 years of work on the purified enzyme. FASEB J. 8, 993-1002 (1994).
14. Penniston, J. T. & Enyedi, A. Modulation of the plasma membrane Ca21 pump. J. Membr. Biol. 165, 101-109 (1998).
15. Baekgaard, L., Luoni, L., De Michelis, M. I. & Palmgren, M. G. The plant plasma membraneCa21pumpACA8contains overlapping aswell asphysically separated autoinhibitory and calmodulin-binding domains. J. Biol. Chem. 281, 1058-1065 (2006).
16. Hoeflich, K. P. & Ikura, M. Calmodulin in action: diversity in target recognition and activation mechanisms. Cell 108, 739-742 (2002).
17. Juranic, N. et al. Calmodulin wraps around its binding domain in the plasma membrane Ca21 pump anchored by a novel 18-1 motif. J. Biol. Chem. 285, 4015-4024 (2010).
18. Ishida, H. & Vogel, H. J. The solution structure of a plant calmodulin and the CaMbinding domain of the vacuolar calcium-ATPase BCA1 reveals a new binding and activation mechanism. J. Biol. Chem. 285, 38502-38510 (2010).
19. Cunningham, K. W. & Fink, G. R. Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca21 ATPases. J. Cell Biol. 124, 351-363 (1994).
20. Durr, G. et al. The medial-Golgi ion pump Pmr1 supplies the yeast secretory pathway with Ca21 and Mn21 required for glycosylation, sorting, and endoplasmic reticulum-associated protein degradation. Mol. Biol. Cell 9, 1149-1162 (1998).
21. Strehler, E. E. & Zacharias, D. A. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol. Rev. 81, 21-50 (2001).
22. Enyedi, A. et al.TheCa21affinity of the plasmamembraneCa21pumpis controlled by alternative splicing. J. Biol. Chem. 269, 41-43 (1994).
23. Namba, T. et al. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 365, 166-170 (1993).
24. Spengler, D. et al. Differential signal transduction by five splice variants of the PACAP receptor. Nature 365, 170-175 (1993).
25. Fusca, T. et al. Single point mutations in the small cytoplasmic loop of ACA8, a plasma membrane Ca21-ATPase of Arabidopsis thaliana, generate partially deregulated pumps. J. Biol. Chem. 284, 30881-30888 (2009).
26. Meneghelli, S., Fusca, T., Luoni, L. & De Michelis, M. I.Dual mechanismof activation of plant plasma membrane Ca21-ATPase by acidic phospholipids: Evidence for a phospholipid binding site which overlaps with the calmodulin-binding site. Mol. Membr. Biol. 25, 539-546 (2008).
27. Tidow, H., Hein, K. L., Baekgaard, L., Palmgren, M. G. & Nissen, P. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca21-ATPase ACA8. Acta Crystallogr. F 66, 361-363 (2010).
28. Schiott, M. et al. A plant plasma membrane Ca21 pump is required for normal pollen tube growth and fertilization. Proc. Natl Acad. Sci. USA 101, 9502-9507 (2004).