Mesoderm is committed to hemato-endothelial and cardiac lineages in human embryoid bodies by sequential exposure to cytokines

Experimental Cell Research

Volumn 319, Issue 1, 2013, Pages 21-34

  Zhu, Ming Xia ^a   Zhao, Jin Yuan ^a   Chen, Gui An ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Cardiac precursors; Cytokines; Hematopoietic endothelial precursors; Human embryoid bodies; Mesoderm

Indexed keywords

BETA ACTIN; BONE MORPHOGENETIC PROTEIN 4; CD31 ANTIGEN; CD34 ANTIGEN; CYTOKINE; FIBROBLAST GROWTH FACTOR 2; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX2.5; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; EXPOSURE; FLOW CYTOMETRY; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE CELL; HEMANGIOBLAST; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN EMBRYO; HUMAN EMBRYOID BODY; MESODERM; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

EID: 84869088819     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.09.009     Document Type: Article

References (41)

1. Wang L., Li L., Shojaei F., Levac K., Cerdan C., Menendez P., Martin T., Rouleau A., Bhatia M. Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity 2004, 21:31-41.
2. Moreno-Gimeno I., Ledran M.H., Lako M. Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations. FEBS J. 2010, 277:5014-5025.
3. Bekhite M.M., Finkensieper A., Binas S., Muller J., Wetzker R., Figulla H.R., Sauer H., Wartenberg M. VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells. J. Cell Sci. 2011, 124:1819-1830.
4. Kouskoff V., Lacaud G., Schwantz S., Fehling H.J., Keller G. Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc. Natl. Acad. Sci. USA 2005, 102:13170-13175.
5. Choi K., Kennedy M., Kazarov A., Papadimitriou J.C., Keller G. A common precursor for hematopoietic and endothelial cells. Development 1998, 125:725-732.
6. Kenndy M., D'Souza S.L., Lynch-Kattman M., Schwantz S., Keller G. Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 2007, 109:2679-2687.
7. Huber T.L., Kouskoff V., Fehling H.J., Palis J., Keller G. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 2004, 432:625-630.
8. Fehling H.J., Lacaud G., Kubo A., Kennedy M., Robertson S., Keller G., Kouskoff V. Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation. Development 2003, 130:4217-4227.
9. Ema M., Takahashi S., Rossant J. Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood 2006, 107:111-117.
10. Kinder S.J., Tsang T.E., Quinlan G.A., Hadjantonakis A.K., Nagy A., Tam P.P. The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development 1999, 126:4691-4701.
11. Boheler K.R., Czyz J., Tweedie D., Yang H.T., Anisimov S.V., Wobus A.M. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ. Res. 2002, 91:189-201.
12. Yamashita J.K., Takano M., Hiraoka-Kanie M., Shimazu C., Peishi Y., Yanagi K., Nakano A., Inoue E., Kita F., Nishikawa S. Prospective identification of cardiac progenitors by a novel single cell-based cardiomyocyte induction. FASEB J. 2005, 19:1534-1536.
13. Chen V.C., Stull R., Joo D., Cheng X., Keller G. Notch signaling respecifies the hemangioblast to a cardiac fate. Nat. Biotechnol. 2008, 26:1169-1178.
14. Chadwick K., Wang L., Li L., Menendez P., Murdoch B., Rouleau A., Bhatia M. Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 2003, 102:906-915.
15. Pearson S., Sroczynska P., Lacaud G., Kouskoff V. The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF. Development 2008, 135:1525-1535.
16. Purpura K.A., Morin J., Zandstra P.W. Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media. Exp. Hematol. 2008, 36:1186-1198.
17. Wang C., Tang X., Sun X., Miao Z., Lv Y., Yang Y., Zhang H., Zhang P., Liu Y., Du L., Gao Y., Yin M., Ding M., Deng H. TGFΒ inhibition enhances the generation of hematopoietic progenitors from human ES cell-dervied hemogenic endothelial cells using a stepwise strategy. Cell Res. 2012, 22:194-207.
18. Peng H., Chen G. Serum-free medium cultivation to improve efficacy in establishment of human embryonic stem cell lines. Hum. Reprod. 2006, 21:217-222.
19. Nissen-Druey C., Tichelli A., Meyer-Monard S. Human Hematopoietic Colonies in Health and Disease 2005, Karger, Switzerland.
20. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta deltaC (T)) method. Methods 2001, 25:402-408.
21. Krause D.S., Fackler M.J., Civin C.I., May W.S. CD34: structure, biology, and clinical utility. Blood 1996, 87:1-13.
22. Sasaki T., Sasaki-Irie J., Penninger J.M. New insights into the transmembrane protein tyrosine phosphatase CD45. Int. J. Biochem. Cell Biol. 2001, 33:1041-1046.
23. Begley C.G., Aplan P.D., Denning S.M., Haynes B.F., Waldmann T.A., Kirsch I.R. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc. Natl. Acad. Sci. USA 1989, 86:10128-10132.
24. Zandstra P.W., Bauwens C., Yin T., Liu Q., Schiller H., Zweigerdt R., Pasumarthi K.B., Field L.J. Scalable production of embryonic stem cell-derived cardiomocytes. Tissue Eng. 2003, 9:767-778.
25. Wang H., Gilner J.B., Bautch V.L., Wang D.Z., Wainwright B.J., Kirby S.L., Patterson C. Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. J. Biol. Chem. 2007, 282:782-791.
26. Parsons X.H., Teng Y.D., Parsons J.F., Snyder E.Y., Smotrich D.B., Moore D.A. Efficient derivation of human neuronal progenitors and neurons from pluripotent human embryonic stem cells with small molecule induction. J. Vis. Exp. 2011, 56:e3273.
27. Xu X., Browning V.L., Odorico J.S. Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech. Dev. 2011, 128:412-427.
28. Kimelman D. Medoderm induction: from caps to chips. Nat. Rev. Genet. 2006, 7:360-372.
29. Kispert A., Hermann B.G. The Brachyury gene encodes a novel binding protein. EMBO J. 1993, 12:4898-4899.
30. Kennedy M., D'Souza S.L., Lynch-Kattman M., Schwantz S., Keller G. Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 2007, 109:2679-2687.
31. Zhang P., Li J., Tan Z., Wang C., Liu T., Chen L., Yong J., Jiang W., Sun X., Du L., Ding M., Deng H. BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood 2008, 111:1933-1941.
32. Robertson S.M., Kennedy M., Schannon J.M., Keller G. A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1. Development 2000, 127:2447-2459.
33. Garry D.J., Olson E.N. A common progenitor at the heart of development. Cell 2006, 127:1101-1104.
34. Takei S., Ichikawa H., Johkura K., Mogi A., No H., Yoshie S., Tomotsune D., Sasaki K. Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:1793-1803.
35. Ishitobi H., Wakamatsu A., Liu F., Azami T., Hamada M., Matsumoto K., Kataoka H., Kobayashi M., Choi K., Nishikawa S., Takahashi S., Ema M. Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse. Development 2011, 138:5357-5368.
36. Ciruna B., Rossant J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev. Cell 2000, 1:37-49.
37. Pick M., Azzola L., Mossman A., Stanley E.G., Elefanty A.G. Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic p rotein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis. Stem Cells 2007, 25:2206-2214.
38. Sitnicka E., Lin N., Priestley G.V., Fox N., Broudy V.C., Wolf N.S., Kaushansky K. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996, 87:4998-5005.
39. Wang Z., Skokowa J., Pramono A. Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cells. Ann. N. Y. Acad. Sci 2005, 1044:29-40.
40. Srivastava A.S., Nedelcu E., Esmaeli-Azad B., Mishra R., Carrier E. Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells. Stem Cells 2007, 25:1456-1461.
41. Song Y.H., Gehmert S., Sadat S., Pinkernell K., Bai X., Matthias N., Alt E. VEGF is critical for spontaneous differentiation of stem cells into cardiomyocytes. Biochem. Biophys. Res. Commun. 2007, 354:999-1003.