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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7097-7099

Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors

(4) Moure, Alejandra a Orzáez, Mar b Sancho, Mónica b Messeguer, Angel a

a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC (Spain)

b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE (Spain)

Author keywords

1,4 Piperazine 2,5 dione; Apoptosis inhibitors; Chiral compounds; Enantioselective synthesis; Perhydro 1,4 diazepine 2,5 dione

Indexed keywords

1,4 PIPERAZINE 2,5 DIONE DERIVATIVE; APOPTOSIS INHIBITOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; DIAZEPINE DERIVATIVE; PERHYDRO 1,4 DIAZEPINE 2,5 DIONE DERIVATIVE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; APOPTOSIS; ARTICLE; CHIRALITY; CYCLIZATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; RACEMIC MIXTURE;

APOPTOSIS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; AZEPINES; HEK293 CELLS; HUMANS; PEPTIDOMIMETICS; PIPERAZINES; PROTEIN BINDING; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 84869088078 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.09.078 Document Type: Article

Times cited : (9)

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