Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5- hydroxyindole as a novel CaMKII inhibitor

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 23, 2012, Pages 6840-6847

  Komiya, Masafumi ^a   Asano, Shigehiro ^a   Koike, Nobuyuki ^a   Koga, Erina ^a   Igarashi, Junetsu ^a   Nakatani, Shogo ^a   Isobe, Yoshiaki ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Calmodulin; CaMKII; Indole; Inhibitor; Kinase

Indexed keywords

(4 BROMO 5 HYDROXY 1H INDOL 2 YL)(4 PHENOXYPHENYL)METHANONE; (4,6 DIBROMO 5 HYDROXY 1H INDOL 2 YL)(4 PHENOXYPHENYL)METHANONE; 2 (4 PHENOXYBENZOYL) 5 HYDROXYINDOLE; 5 HYDROXYINDOLE DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; HYDROXYL GROUP; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSIN LIGHT CHAIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C GAMMA; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; INFRARED SPECTROSCOPY; LIPOPHILICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DRUG DESIGN; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869086943     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.09.048     Document Type: Article

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