5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6696-6698

  Asano, Shigehiro ^a   Komiya, Masafumi ^a   Koike, Nobuyuki ^a   Koga, Erina ^a   Nakatani, Shogo ^a   Isobe, Yoshiaki ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

5,6,7,8 Tetrahydropyrido 4,3 d pyrimidines; Calmodulin dependent protein kinase II; Inhibitors

Indexed keywords

5,6,7,8 TETRAHYDROPYRIDO[4,3 DELTA]PYRIMIDINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MICHAELIS MENTEN KINETICS;

CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; PROTEIN KINASE INHIBITORS; PYRIMIDINES;

EID: 77958073838     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.005     Document Type: Article

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