Andropause: A review of the definition and treatment

European Geriatric Medicine

Volumn 3, Issue 6, 2012, Pages 368-373

  Samaras, N ^a   Frangos, E ^b   Forster, A ^a   Lang, P O ^c,d   Samaras, D ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b Clinique de Jolimont   (Switzerland)

^c Nescens Centre of Preventive Medicine   (Switzerland)

^d CRANFIELD UNIVERSITY   (United Kingdom)

Author keywords

Andropause; Elderly; Hormones; Treatment

Indexed keywords

ESTROGEN; FLUOXYMESTERONE; FOLLITROPIN; LUTEINIZING HORMONE; METHYLTESTOSTERONE; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE; TESTOSTERONE CIPIONATE; TESTOSTERONE ENANTATE; TESTOSTERONE UNDECANOATE;

ACNE; ALCOHOL CONSUMPTION; ANDROPAUSE; BRACHYTHERAPY; BREAST TENDERNESS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DRUG ABSORPTION; EXTERNAL BEAM RADIOTHERAPY; FOLLITROPIN BLOOD LEVEL; FOLLOW UP; GYNECOMASTIA; HORMONAL THERAPY; HUMAN; HYPOGONADISM; LIFESTYLE; LUTEINIZING HORMONE BLOOD LEVEL; MALE FERTILITY; MORNING DOSAGE; PENIS ERECTION; PHYSICAL ACTIVITY; POLYCYTHEMIA; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; REVIEW; SEXUAL BEHAVIOR; SIDE EFFECT; SKIN IRRITATION; SLEEP DISORDERED BREATHING; SMOKING; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL;

EID: 84869085737     PISSN: 18787649     EISSN: 18787657     Source Type: Journal    
DOI: 10.1016/j.eurger.2012.08.007     Document Type: Article

References (72)

1. Z. Hyde, L. Flicker, O.P. Almeida, G.J. Hankey, K.A. McCaul, and S.A. Chubb Low free testosterone predicts frailty in older men: the health in men study J Clin Endocrinol Metab 95 2010 3165 7312
2. R. Suzuki, N.E. Allen, P.N. Appleby, T.J. Key, L. Dossus, and A. Tjonneland Lifestyle factors and serum androgens among 636 middle-aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cancer Causes Control 20 2009 811 821
3. J.F. Dunn, B.C. Nisula, and D. Rodbard Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma J Clin Endocrinol Metab 53 1981 58 68 (Pubitemid 13245381)
4. W.M. Pardridge Serum bioavailability of sex steroid hormones Clin Endocrinol Metab 15 1986 259 278 (Pubitemid 16001796)
5. B. Campbell, P. Leslie, and K. Campbell Age-related changes in testosterone and SHBG among Turkana males Am J Hum Biol 18 2006 71 82 (Pubitemid 43137095)
6. E. Leifke, V. Gorenoi, C. Wichers, A. Von Zur Muhlen, E. Von Buren, and G. Brabant Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex hormone binding globulin levels in men: cross-sectional data from a healthy male cohort Clin Endocrinol (Oxf) 53 2000 689 695 (Pubitemid 32096679)
7. B. Lapauw, S. Goemaere, H. Zmierczak, I. Van Pottelbergh, A. Mahmoud, and Y. Taes The decline of serum testosterone levels in community-dwelling men over 70 years of age: descriptive data and predictors of longitudinal changes Eur J Endocrinol 159 2008 459 468
8. S. Rohrmann, E.A. Platz, E. Selvin, M.S. Shiels, and C.E. Joshu The prevalence of low sex steroid hormone concentrations in men in the Third National Health and Nutrition Examination Survey (NHANES III) Clin Endocrinol (Oxf) 75 2011 232 239
9. M. Wald, R.B. Meacham, L.S. Ross, and C.S. Niederberger Testosterone replacement therapy for older men J Androl 27 2006 126 132
10. A. Morales, and B. Lunenfeld Investigation, treatment and monitoring of late-onset hypogonadism in males. Official recommendations of ISSAM. International Society for the Study of the Aging Male Aging Male 5 2002 74 86
11. Lang PO, Samaras D, Samaras N. Testosterone Replacement Therapy in Reversing. "Andropause": What Is the Proof-of-Principle? Rejuvenation Res. Epub 2012.
12. S. Bhasin, G.R. Cunningham, F.J. Hayes, A.M. Matsumoto, P.J. Snyder, and R.S. Swerdloff Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline J Clin Endocrinol Metab 95 2010 2536 2559
13. M. Maggio, G.P. Ceda, F. Lauretani, S. Bandinelli, and E.J. Metter Gonadal status and physical performance in older men Aging Male 14 2011 42 47
14. T. Hayashi, and T. Yamada Association of bioavailable estradiol levels and testosterone levels with serum albumin levels in elderly men Aging Male 11 2008 63 70 (Pubitemid 351878776)
15. M.H. Emmelot-Vonk, H.J. Verhaar, H.R. Nakhai-Pour, A. Aleman, T.M. Lock, and J.L. Bosch Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial JAMA 299 2008 39 52
16. L. Ferrucci, M. Maggio, S. Bandinelli, S. Basaria, F. Lauretani, and A. Ble Low testosterone levels and the risk of anemia in older men and women Arch Intern Med 166 2006 1380 1388 (Pubitemid 44036350)
17. E. Frangos, K. Samii, J.J. Perrenoud, and U.M. Vischer Anemia in the elderly: a frequent condition that should not be overlooked Rev Med Suisse 6 2010 2125 2129
18. C. Li, E.S. Ford, B. Li, W.H. Giles, and S. Liu Association of testosterone and sex hormone binding globulin with metabolic syndrome and insulin resistance in men Diabetes Care 33 2010 1618 1624
19. J.E. Morley, M.J. Kim, and M.T. Haren Frailty and hormones Rev Endocr Metab Disord 6 2005 101 108 (Pubitemid 40603511)
20. F.C. Wu, A. Tajar, S.R. Pye, A.J. Silman, J.D. Finn, and T.W. O'Neill Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study J Clin Endocrinol Metab 93 2008 2737 2745 (Pubitemid 352008544)
21. F.C. Wu, A. Tajar, J.M. Beynon, S.R. Pye, A.J. Silman, and J.D. Finn Identification of late-onset hypogonadism in middle-aged and elderly men N Engl J Med 363 2010 123 135
22. M. Oettel, D. Hubler, and V. Patchev Selected aspects of endocrine pharmacology of the aging male Exp Gerontol 38 2003 189 198 (Pubitemid 36110513)
23. J.M. Kaufman, and A. Vermeulen The decline of androgen levels in elderly men and its clinical and therapeutic implications Endocr Rev 26 2005 833 876 (Pubitemid 41428540)
24. E. Barrett-Connor, D.G. Von Muhlen, and D. Kritz-Silverstein Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study J Clin Endocrinol Metab 84 1999 573 577 (Pubitemid 29075686)
25. S. Rohrmann, M.S. Shiels, D.S. Lopez, N. Rifai, W.G. Nelson, and N. Kanarek Body fatness and sex steroid hormone concentrations in US men: results from NHANES III Cancer Causes Control 22 2011 1141 1151
26. M.S. Shiels, S. Rohrmann, A. Menke, E. Selvin, C.J. Crespo, and N. Rifai Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men Cancer Causes Control 20 2009 877 886
27. M. Maneesh, S. Dutta, A. Chakrabarti, and D.M. Vasudevan Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males Indian J Physiol Pharmacol 50 2006 291 296 (Pubitemid 44221173)
28. Z. Hyde, L. Flicker, G.J. Hankey, O.P. Almeida, K.A. McCaul, and S.A. Chubb Prevalence and predictors of sexual problems in men aged 75-95 years: a population-based study J Sex Med 9 2012 442 453
29. R.M. Coward, J. Simhan, and C.C. Carson Prostate specific antigen changes and prostate cancer in hypogonadal men treated with testosterone replacement therapy BJU Int 103 2009 1179 1183
30. S. Bhasin, and S. Basaria Diagnosis and treatment of hypogonadism in men Best Pract Res Clin Endocrinol Metab 25 2011 251 270
31. A.M. Isidori, E. Giannetta, D. Gianfrilli, E.A. Greco, V. Bonifacio, and A. Aversa Effects of testosterone on sexual function in men: results of a meta-analysis Clin Endocrinol (Oxf) 63 2005 381 394 (Pubitemid 41442332)
32. M. Khera Androgens and erectile function: a case for early androgen use in postprostatectomy hypogonadal men J Sex Med 6 Suppl. 3 2009 234 238
33. Report of national institute on aging advisory panel on testosterone replacement in men J Clin Endocrinol Metab 86 2001 4611 4614
34. T. van der Poll, J.A. Romijn, E. Endert, and H.P. Sauerwein Effects of tumor necrosis factor on the hypothalamic-pituitary-testicular axis in healthy men Metabolism 42 1993 303 307 (Pubitemid 23073346)
35. J.E. Morley, E. Charlton, P. Patrick, F.E. Kaiser, P. Cadeau, and D. McCready Validation of a screening questionnaire for androgen deficiency in aging males Metabolism 49 2000 1239 1242
36. L.A. Heinemann, F. Saad, T. Zimmermann, A. Novak, E. Myon, and X. Badia The Aging Males' Symptoms (AMS) scale: update and compilation of international versions Health Qual Life Outcomes 1 2003 15
37. L.A.J. Heinemann, T. Zimmermann, and Vermeulen A A New "Aging Male's Symptoms" (AMS) rating scale Aging Male 1999 105 114 (Pubitemid 29411279)
38. M.H. Emmelot-Vonk, H.J. Verhaar, H.R. Nakhai-Pour, D.E. Grobbee, and Y.T. van der Schouw Low testosterone concentrations and the symptoms of testosterone deficiency according to the Androgen Deficiency in Ageing Males (ADAM) and Ageing Males' Symptoms rating scale (AMS) questionnaires Clin Endocrinol (Oxf) 74 2011 488 494
39. A.C. Spetz, L. Palmefors, R.S. Skobe, M.T. Stromstedt, M.G. Fredriksson, and E. Theodorsson Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population Menopause 14 2007 999 1005 (Pubitemid 350098659)
40. E.L. Rhoden, and A. Morgentaler Risks of testosterone replacement therapy and recommendations for monitoring N Engl J Med 350 2004 482 492 (Pubitemid 38133769)
41. M.J. Barry, F.J. Fowler Jr., M.P. O'Leary, R.C. Bruskewitz, H.L. Holtgrewe, and W.K. Mebust The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association J Urol 148 1992 1549 1557
42. A.S. Dobs, A.W. Meikle, S. Arver, S.W. Sanders, K.E. Caramelli, and N.A. Mazer Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men J Clin Endocrinol Metab 84 1999 3469 3478 (Pubitemid 30645193)
43. A.D. Coviello, B. Kaplan, K.M. Lakshman, T. Chen, A.B. Singh, and S. Bhasin Effects of graded doses of testosterone on erythropoiesis in healthy young and older men J Clin Endocrinol Metab 93 2008 914 919 (Pubitemid 351398573)
44. P.M. Pierorazio, L. Ferrucci, A. Kettermann, D.L. Longo, E.J. Metter, and H.B. Carter Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal Study of Aging BJU Int 105 2010 824 829
45. R.C. Travis, T.J. Key, N.E. Allen, P.N. Appleby, A.W. Roddam, and S. Rinaldi Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition Int J Cancer 121 2007 1331 1338 (Pubitemid 47293802)
46. A.W. Roddam, N.E. Allen, P. Appleby, and T.J. Key Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies J Natl Cancer Inst 100 2008 170 183 (Pubitemid 351480553)
47. A.B. Barqawi, and E.D. Crawford Testosterone replacement therapy and the risk of prostate cancer: a perspective view Int J Impot Res 17 2005 462 463 (Pubitemid 43093249)
48. A. Morgentaler Testosterone replacement therapy and prostate cancer Urol Clin North Am 34 2007 555 563 (Pubitemid 350029943)
49. A. Morgentaler Testosterone and prostate cancer: what are the risks for middle-aged men? Urol Clin North Am 38 2011 119 124
50. M.F. Sarosdy Testosterone replacement for hypogonadism after treatment of early prostate cancer with brachytherapy Cancer 109 2007 536 541 (Pubitemid 46190961)
51. A. Morales, A.M. Black, and L.E. Emerson Testosterone administration to men with testosterone deficiency syndrome after external beam radiotherapy for localized prostate cancer: preliminary observations BJU Int 103 2009 62 64
52. S. Basaria, A.D. Coviello, T.G. Travison, T.W. Storer, W.R. Farwell, and A.M. Jette Adverse events associated with testosterone administration N Engl J Med 363 2010 109 122
53. G.A. Laughlin, E. Barrett-Connor, and J. Bergstrom Low serum testosterone and mortality in older men J Clin Endocrinol Metab 93 2008 68 75
54. K.T. Khaw, M. Dowsett, E. Folkerd, S. Bingham, N. Wareham, and R. Luben Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) prospective population study Circulation 116 2007 2694 2701 (Pubitemid 350291241)
55. R. Haring, H. Volzke, A. Steveling, A. Krebs, S.B. Felix, and C. Schofl Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79 Eur Heart J 31 2010 1494 1501
56. A.B. Araujo, V. Kupelian, S.T. Page, D.J. Handelsman, W.J. Bremner, and J.B. McKinlay Sex steroids and all cause and cause-specific mortality in men Arch Intern Med 167 2007 1252 1260 (Pubitemid 46998496)
57. T. Vikan, H. Schirmer, I. Njolstad, and J. Svartberg Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromso Study Eur J Endocrinol 161 2009 435 442
58. Z. Hyde, P.E. Norman, L. Flicker, G.J. Hankey, K.A. McCaul, and O.P. Almeida predicts ischaemic heart disease events in older men: the Health in Men Study Eur J Endocrinol 164 2011 569 577
59. B.B. Yeap, Z. Hyde, P.E. Norman, S.A. Chubb, and J. Golledge Associations of total testosterone, sex hormone binding globulin, calculated free testosterone, and luteinizing hormone with prevalence of abdominal aortic aneurysm in older men J Clin Endocrinol Metab 95 2010 1123 1130
60. G.M. Rosano, I. Sheiban, R. Massaro, P. Pagnotta, G. Marazzi, and C. Vitale Low testosterone levels are associated with coronary artery disease in male patients with angina Int J Impot Res 19 2007 176 182 (Pubitemid 46340835)
61. K.M. English, O. Mandour, R.P. Steeds, M.J. Diver, and T.H. Jones Channer KS. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms Eur Heart J 21 2000 890 894 (Pubitemid 30307417)
62. B.B. Yeap, Z. Hyde, O.P. Almeida, P.E. Norman, S.A. Chubb, and K. Jamrozik Lower testosterone levels predict incident stroke and transient ischemic attack in older men J Clin Endocrinol Metab 94 2009 2353 2359
63. C. Ohlsson, E. Barrett-Connor, S. Bhasin, E. Orwoll, F. Labrie, and M.K. Karlsson High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. The MrOS (Osteoporotic Fractures in Men) study in Sweden J Am Coll Cardiol 58 2011 1674 1681
64. P.Y. Liu, A.K. Death, and D.J. Handelsman Androgens and cardiovascular disease Endocr Rev 24 2003 313 340 (Pubitemid 36724373)
65. G.M. Rosano, F. Leonardo, P. Pagnotta, F. Pelliccia, G. Panina, and E. Cerquetani Acute anti-ischemic effect of testosterone in men with coronary artery disease Circulation 99 1999 1666 1670 (Pubitemid 29162477)
66. C.M. Webb, J.G. McNeill, C.S. Hayward, D. de Zeigler, and P. Collins Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease Circulation 100 1999 1690 1696 (Pubitemid 29485250)
67. K.M. English, R.P. Steeds, T.H. Jones, M.J. Diver, and K.S. Channer Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study Circulation 102 2000 1906 1911
68. P. Dandona, S. Dhindsa, A. Chaudhuri, V. Bhatia, and S. Topiwala Hypogonadotrophic hypogonadism in type 2 diabetes Aging Male 11 2008 107 117
69. M. Maggio, F. Lauretani, G.P. Ceda, S. Bandinelli, S. Basaria, and A. Ble Association between hormones and metabolic syndrome in older Italian men J Am Geriatr Soc 54 2006 1832 1838 (Pubitemid 44915825)
70. S. Torkler, H. Wallaschofski, S.E. Baumeister, H. Volzke, M. Dorr, and S. Felix Inverse association between total testosterone concentrations, incident hypertension and blood pressure Aging Male 14 2011 176 182
71. J.M. Zmuda, M.C. Fahrenbach, B.T. Younkin, L.L. Bausserman, R.B. Terry, and D.H. Catlin The effect of testosterone aromatization on high-density lipoprotein cholesterol level and postheparin lipolytic activity Metabolism 42 1993 446 450 (Pubitemid 23112709)
72. E.A. Whitsel, E.J. Boyko, A.M. Matsumoto, B.D. Anawalt, and D.S. Siscovick Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis Am J Med 111 2001 261 269 (Pubitemid 32885620)