A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel

Journal of Cardiovascular Electrophysiology

Volumn 23, Issue 11, 2012, Pages 1246-1253

  Kinoshita, Koshi ^a   Yamaguchi, Yoshiaki ^a   Nishide, Kohki ^b   Kimoto, Katsuya ^b   Nonobe, Yuki ^b   Fujita, Akira ^b   Asano, Kenta ^b   Tabata, Toshihide ^b   Mori, Hisashi ^a   Inoue, Hiroshi ^a   Hata, Yukiko ^a   Fukurotani, Kenkichi ^b   Nishida, Naoki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

arrhythmia; HEK 293T cell; hERG(G487R); Kv11.1; KCNH2; patch clamp; sudden death

Indexed keywords

POTASSIUM CHANNEL HERG;

AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; FEMALE; HEART DEPOLARIZATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VOLTAGE CLAMP; WHOLE CELL; WILD TYPE;

ACTION POTENTIALS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARRHYTHMIAS, CARDIAC; CELL MEMBRANE; DEATH, SUDDEN, CARDIAC; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; ION CHANNEL GATING; KINETICS; MALE; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PATCH-CLAMP TECHNIQUES; PHENOTYPE; POTASSIUM; PROTEIN SUBUNITS; TRANSFECTION; YOUNG ADULT;

EID: 84869083801     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2012.02383.x     Document Type: Article

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