The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7100-7105

  Pfefferkorn, Jeffrey A ^a   Tu, Meihua ^a   Filipski, Kevin J ^a   Guzman Perez, Angel ^a   Bian, Jianwei ^a   Aspnes, Gary E ^a   Sammons, Matthew F ^a   Song, Wei ^a   Li, Jian Cheng ^a   Jones, Christopher S ^a   Patel, Leena ^a   Rasmusson, Tim ^a   Zeng, Dongxiang ^a   Karki, Kapil ^a   Hamilton, Michael ^a   Hank, Richard ^a   Atkinson, Karen ^a   Litchfield, John ^a   Aiello, Robert ^a   Baker, Levenia ^a   Barucci, Nicole ^a   Bourassa, Patricia ^a   Bourbounais, Francis ^a   D'Aquila, Theresa ^a   Derksen, David R ^a   MacDougall, Margit ^a   Robertson, Alan ^a   more..

^a PFIZER INC   (United States)

Author keywords

Glucokinase activator; Type 2 diabetes mellitus

Indexed keywords

4 [6 (AZETIDINE 1 CARBONYL) 5 FLUOROPYRIDIN 3 YLOXY] 2 ETHYL N(5 METHYLPYRAZIN 2 YL) 2H INDAZOLE 6 CARBOXAMIDE; ENZYME ACTIVATOR; GLUCOKINASE ACTIVATOR; INDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; HUMAN; HYPOGLYCEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; GLUCOKINASE; GLUCOSE TOLERANCE TEST; HALF-LIFE; HUMANS; HYPOGLYCEMIC AGENTS; INDAZOLES; INSULIN; KINETICS; PROTEIN BINDING; PYRAZINES; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869083332     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.082     Document Type: Article

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