Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus

Veterinary Microbiology

Volumn 160, Issue 3-4, 2012, Pages 455-462

  He, Yuli ^a   Wang, Gang ^a   Liu, Yonggang ^a   Shi, Wenda ^a   Han, Zifeng ^b   Wu, Jianan ^a   Jiang, Chenggang ^a   Wang, Shujie ^a   Hu, Shouping ^a   Wen, Huiqiang ^a   Dong, Jianguo ^a   Liu, He ^a   Cai, Xuehui ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b NORTHEAST AGRICULTURAL UNIVERSITY   (China)

Author keywords

Apoptosis; Highly pathogenic PRRSV; PRRSV; Thymus atrophy; Ultrastructure

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTERIVIRUS; ARTERIVIRUS INFECTION; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ELECTRON MICROSCOPY; HISTOPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGLET; SWINE DISEASE; T CELL DEPLETION; THYMOCYTE; THYMUS ATROPHY; VIREMIA; VIRUS LOAD;

ANIMALS; APOPTOSIS; ATROPHY; BODY WEIGHT; MICROSCOPY, ELECTRON, TRANSMISSION; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; RANDOM ALLOCATION; SWINE; T-LYMPHOCYTES; THYMOCYTES; THYMUS GLAND; VIRAL LOAD; VIREMIA;

PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS;

EID: 84869083280     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2012.05.040     Document Type: Article

References (25)

1. Aspinall R. Age-associated thymic atrophy in the mouse is dueto a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J. Immunol. 1997, 158(158):3037-3045.
2. Benson J.E., Yaeger M.J., Christopher-Hennings J., Lager K., Yoon K.J. A comparison of virus isolation, immunohistochemistry, fetal serology, and reverse-transcription polymerase chain reaction assay for the identification of porcine reproductive and respiratory syndrome virus transplacental infection in the fetus. J. Vet. Diagn. Invest. 2002, 14:8-14.
3. Choi C., Chae C. Expression of tumour necrosis factor-alpha is associated with apoptosis in lungs of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. Res. Vet. Sci. 2002, 72:45-49.
4. Collins J.E., Benfield D.A., Christianson W.T., Harris L., Hennings J.C., Shaw D.P., Goyal S.M., McCullough S., Morrison R.B., Joo H.S. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J. Vet. Diagn. Invest. 1992, 4:117.
5. Done S.H., Paton D.J. Porcine reproductive and respiratory syndrome: clinical disease, pathology and immunosuppression. Vet. Rec. 1995, 136:32-35.
6. Feng W.H., Tompkins M.B., Xu J.S., Brown T.T., Laster S.M., Zhang H.X., McCaw M.B. Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus. Virology 2002, 302:363-372.
7. Galina L., Pijoan C., Sitjar M., Christianson W.T., Rossow K., Collins J.E. Interaction between Streptococcus suis serotype 2 and porcine reproductive and respiratory syndrome virus in specific pathogen-free piglets. Vet. Rec. 1994, 134:60-64.
8. Halbur P.G., Paul P.S., Frey M.L., Landgraf J., Eernisse K., Meng X.J., Andrews J.J., Lum M.A., Rathje J.A. Comparison of the antigen distribution of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Vet. Pathol. 1996, 33:159-170.
9. Liu Y., Shi W., Zhou E., Wang S., Hu S., Cai X., Rong F., Wu J., Xu M., Li L. Dynamic changes in inflammatory cytokines in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Clin. Vaccine Immunol. 2010, 17:1439-1445.
10. Pol J.M., van Dijk J.E., Wensvoort G., Terpstra C. Pathological, ultrastructural, and immunohistochemical changes caused by Lelystad virus in experimentally induced infections of mystery swine disease (synonym: porcine epidemic abortion and respiratory syndrome (PEARS)). Vet. Q. 1991, 13:137-143.
11. Qiu H.J., Tian Z.J., Tong G.Z., Zhou Y.J., Ni J.Q., Luo Y.Z., Cai X.H. Protective immunity induced by a recombinant pseudorabies virus expressing the GP5 of porcine reproductive and respiratory syndrome virus in piglets. Vet. Immunol. Immunopathol. 2005, 106:309-319.
12. Rodríguez-Ropon A., Hernández-Jauregui P., Sánchez-Torres L., Favila-Castillo L., Estrada-Parra S., Moreno-Lopez J., Kennedy S. Apoptosis in lymph nodes and changes in lymphocyte subpopulations in peripheral blood of pigs infected with porcine rubulavirus. J. Comp. Pathol. 2003, 128:1-8.
13. Rossow K.D. Porcine reproductive and respiratory syndrome. Vet. Pathol. 1998, 35:1-20.
14. Rossow K.D., Benfield D.A., Goyal S.M., Nelson E.A., Christopher-Hennings J., Collins J.E. Chronological immunohistochemical detection and localization of porcine reproductive and respiratory syndrome virus in gnotobiotic pigs. Vet. Pathol. 1996, 33:551-556.
15. Rowland R.R. The interaction between PRRSV and the late gestation pig fetus. Virus Res. 2010, 154:114-122.
16. Sgonc R., Wick G. Methods for the detection of apoptosis. Int. Arch. Allergy Immunol. 1994, 105:327-332.
17. Snijder E.J., Meulenberg J.J. The molecular biology of arteriviruses. J. Gen. Virol. 1998, 79(Pt 5):961-979.
18. Suarez P., Diaz-Guerra M., Prieto C., Esteban M., Castro J.M., Nieto A., Ortin J. Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis. J. Virol. 1996, 70:2876-2882.
19. Sur J.H., Doster A.R., Christian J.S., Galeota J.A., Wills R.W., Zimmerman J.J., Osorio F.A. Porcine reproductive and respiratory syndrome virus replicates in testicular germ cells, alters spermatogenesis, and induces germ cell death by apoptosis. J. Virol. 1997, 71:9170-9179.
20. Sur J.H., Doster A.R., Osorio F.A. Apoptosis induced in vivo during acute infection by porcine reproductive and respiratory syndrome virus. Vet. Pathol. 1998, 35:506-514.
21. Thanawongnuwech R., Halbur P.G., Andrews J.J. Immunohistochemical detection of porcine reproductive and respiratory syndrome virus antigen in neurovascular lesions. J. Vet. Diagn. Invest. 1997, 9:334-337.
22. Tian Z.J., An T.Q., Zhou Y.J., Peng J.M., Hu S.P., Wei T.C., Jiang Y.F., Xiao Y., Tong G.Z. An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS. Vet. Microbiol. 2009, 138:34-40.
23. Tong G.Z., Zhou Y.J., Hao X.F., Tian Z.J., An T.Q., Qiu H.J. Highly pathogenic porcine reproductive and respiratory syndrome. China. Emerg. Infect. Dis. 2007, 13:1434-1436.
24. Wang G., Song T., Yu Y., Liu Y., Shi W., Wang S., Rong F., Dong J., Liu H., Cai X., Zhou E.M. Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 2011, 142:170-178.
25. Wensvoort G., Terpstra C., Pol J.M., ter Laak E.A., Bloemraad M., de Kluyver E.P., Kragten C., van Buiten L., den Besten A., Wagenaar F., et al. Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet. Q. 1991, 13:121-130.